Acknowledgement to referees     

Georg Erhardt  Franz Pirchner  Lawrence R. Schaeffer  Henner Simianer  Gerald Stranzinger 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2003,120(1):68-72

  相似文献   

Gossypol toxicity in preruminant calves     

RZ ZELSKI  JT ROTHWELL†  RE MOORE‡  DJ KENNEDY§ 《Australian veterinary journal》1995,72(10):394-398

SUMMARY Twenty-four of 57 calves fed a diet containing 33% cotton seed meal (CSM) died between 7 and 15 weeks of age. Initial deaths were not accompanied by premonitory signs, but after CSM withdrawal most calves developed rough coats, anorexia, weakness, ascites and subcutaneous oedema. Those that died had large volumes of serous fluid in the body cavities, hard livers of ‘nutmeg’ appearance, and pulmonary congestion. Histopathologically the livers showed periacinar necrosis in acute cases and periacinar fibrosis in chronic cases. Lungs from several calves had oedema, haemosiderosis and fibrosis in some pulmonary vessels. Atrophy of myocardial fibres was present in most cases. The concentration of free gossypol in the diet was 100 to 220 mg/kg. Ante-mortem and post-mortem findings supported a diagnosis of gossypol poisoning. The deaths continued for 4 weeks after withdrawal of CSM from the diet.  相似文献   

Radiographic,computed tomographic,and arthroscopic diagnosis of radioulnar incongruence in dogs with medial coronoid disease          下载免费PDF全文

Dominique J. Griffon DMV  MS  PhD  DECVS  DACVS  Ayman A. Mostafa BVSc  MVSc  PhD  Laurent Blond DMV  MSc  DACVR  David J. Schaeffer PhD 《Veterinary surgery : VS》2018,47(3):333-342

  相似文献   

Effects of the sodium‐glucose cotransporter 2 (SGLT2) inhibitor velagliflozin,a new drug with therapeutic potential to treat diabetes in cats          下载免费PDF全文

M. Hoenig  M. Clark  D. J. Schaeffer  D. Reiche 《Journal of veterinary pharmacology and therapeutics》2018,41(2):266-273

Sodium‐glucose cotransporter 2 (SGLT2) inhibitors are used in the treatment of human diabetics. They increase glucose excretion and correct hyperglycemia. We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta‐hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume. Indirect calorimetry, an intravenous glucose tolerance test (IVGTT; 0.8 g/kg) and insulin tolerance test (IVITT) were conducted. All cats tolerated treatment well. Significant changes with D included a decrease in the respiratory exchange ratio, an increase in cholesterol, a small increase in albumin, and a rise in BHB and NEFA. Glucose clearance was unaltered, although less insulin was secreted during the IVGTT (p = .056) suggesting improved insulin sensitivity. IVITT was unchanged. Treatment did not affect glucagon, leptin, or adiponectin. Water intake, urine output, urinary glucose excretion, and the glucose/creatinine ratio but not urinary electrolytes were significantly higher post‐D. We conclude that velagliflozin is a promising drug, which increases urinary glucose excretion in cats and could thereby be beneficial for the treatment of hyperglycemia.  相似文献   

Estimation of genetic parameters for lactational milk yields using two-dimensional random regressions on parities and days in milk in Chinese Simmental cattle   总被引：1，自引：0，他引：1  

R.Q. Yang  H.Y. Ren  L.R. Schaeffer  & S.Z. Xu 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2005,122(1):49-55

A two‐dimensional random regression model with regressions on days in milk (DIM) and parity number was applied to lactational milk yields in Chinese Simmental cattle. Random regressions were fitted for additive genetic and permanent environmental effects using a two‐dimensional polynomial on DIM and parity number. A total of 4340 lactational milk yields from Chinese Simmental cattle which calved between 1980 and early 2000 were used in this study. Variance components were estimated using Bayesian methodology via Gibbs sampling. Variances of random regression coefficients associated with all terms of the polynomials were significant. A covariance function showed that heritabilities of lactational milk yields between 200 and 400 DIM over parities varied between 0.25 and 0.45. Heritabilities of 305‐day milk yields from 1st to 6–8th parities were 0.28, 0.30, 0.32 0.32, 0.32, and 0.31, respectively. Ratios of permanent environment variances to total variances at each DIM were greater than corresponding heritabilities. Generally, genetic correlations were higher between lactational milk yields with similar DIM and parity number.  相似文献   

Effect of early infection on pathotype frequencies in barley powdery mildew (Blumeria graminis f.sp. hordei) populations in field plots     

L. Bousset †  B. Schaeffer  C. de Vallavieille-Pope 《Plant pathology》2001,50(3):317-324

A field experiment with barley powdery mildew ( Blumeria graminis f.sp. hordei ) was designed in order to study how the time of arrival of inoculum in the field influenced pathotype frequencies in the resulting populations. Three isolates belonging to pathotypes that were absent or rare in the local aerial inoculum were used to inoculate field plots of winter barley cv. Plaisant. Two successive inoculations with different combinations of the three isolates were performed with an approximately two-generation delay, and frequencies of inoculated pathotypes were assessed four and nine generations after the first inoculation. Pathotypes of the first inoculated isolates generally persisted throughout the period of sampling; this is described as an 'early arrival' effect. During the epidemics the inoculated isolates were not replaced by isolates from the natural airborne inoculum. Pathotype frequencies depended mainly on the time of arrival of inoculum in the plot, but frequencies also depended on the isolate that had been inoculated. The most frequent isolate, GL1, belonged to the clonal lineage dominant in powdery mildew populations on winter barley in the north of France. These results confirmed that the composition of a powdery mildew population in a field is largely determined by the composition of the initial inoculum.  相似文献   

Dacryops in a red-eared slider (Chrysemys scripta elegans): case report     

Allgoewer I  Göbel T  Stockhaus C  Schaeffer EH 《Veterinary ophthalmology》2002,5(3):231-234

  相似文献   

Evaluation of short-term increased intraocular pressure on flash- and pattern-generated electroretinograms of dogs     

Hamor RE  Gerding PA  Ramsey DT  Whiteley HE  Benson GJ  Schaeffer DJ 《American journal of veterinary research》2000,61(9):1087-1091

OBJECTIVE: To determine the electrodiagnostic and histologic response of short-term increases of intraocular pressure (IOP) on transient pattern electroretinograms (PERG) and flash electroretinograms (FERG) in the eyes of dogs. ANIMALS: 8 healthy mixed-breed dogs. PROCEDURE: Transient PERG and FERG waveforms were recorded from dogs (while anesthetized) as IOP was increased from baseline (7 to 19 mm Hg) to 90 mm Hg. One hundred mean PERG responses and a single FERG response were recorded at each step during 3 recording sessions. Globes of each dog were enucleated after euthanasia on posttreatment day 7 and evaluated by a pathologist. RESULTS: Increases in spatial frequency resulted in decreased amplitudes of N2 (second negative PERG peak). Increases in IOP resulted in decreases in all 3 PERG waveforms and the FERG waveform. All values began to return to baseline after short-term increases in IOP on day 0, and waveforms were not significantly different on posttreatment days 3 and 7 CONCLUSIONS: Data suggest that short-term increases in IOP affect PERG and FERG waveforms, and PERG waveforms are more sensitive to increases in IOP Differences were not detected between treated and control eyes on histologic examination. Further studies are necessary to determine at what IOP permanent damage to ganglion and photoreceptor cells will develop and whether PERG is a reliable clinical diagnostic technique for use in dogs to reveal retinal damage that is secondary to increased IOP prior to changes in waveforms generated by FERG in dogs.  相似文献   

Realignment of the radius in canine antebrachial growth deformities treated with corrective osteotomy and bilateral (type II) external fixation     

Quinn MK  Ehrhart N  Johnson AL  Schaeffer DJ 《Veterinary surgery : VS》2000,29(6):558-563

OBJECTIVE: To identify factors affecting radial alignment after oblique corrective osteotomy stabilized with a type II external fixator and to evaluate the results of this treatment for antebrachial growth deformities. STUDY DESIGN: Retrospective study SAMPLE POPULATION: Twenty-eight dogs with unilateral antebrachial growth deformities treated with acute corrective osteotomy stabilized with a type II external fixator. METHODS: Medical records and preoperative and postoperative radiographs of the affected and contralateral limb were reviewed. Cause of deformity, age, weight, and gender were recorded. Radial length, varus/valgus angulation, and cranial/caudal angulation were measured from radiographs of the treated and contralateral limbs. Preoperative and postoperative angulation and length discrepancy were compared between affected and contralateral limbs. RESULTS: Correction of varus/valgus angle discrepancy was achieved by using acute corrective osteotomy stabilized with type II external skeletal fixation. No significant change was noted for correction of cranial/caudal angle discrepancy or length discrepancy between the affected and control limb. CLINICAL RELEVANCE: Varus/valgus angle deformities can be treated successfully with type III external fixation after oblique corrective osteotomy. Patients with significant length or cranial/caudal angle discrepancies or both that negatively impact function may require the use of hinged circular fixators or other dynamic techniques to achieve adequate correction.  相似文献   

Precision of estimated QTL positions in granddaughter designs using combined haplotype sharing TDT and linkage analysis     

Davood Kolbehdari  Gerald B. Jansen  Ian McMillan  L.R. Schaeffer   《Livestock Science》2006,105(1-3):137-143

The aim of this study was to develop the linear haplotype sharing transmission disequilibrium test (LHS-TDT) method and combine this method with the simple regression method to estimate the precision of QTL positions in granddaughter designs. This precision was determined by Monte Carlo simulation in granddaughter designs. A single bi-allelic QTL at the midpoint of a linkage group and 26 markers with 1 cM intervals and with two alleles each were simulated. Three linear models, (i.e. the simple regression model, the linear haplotype sharing TDT method and the combination of these two models) were compared. The mean of absolute differences (A) between the estimated and true QTL position of each method was considered for six different scenarios consisting of combinations of a number of markers and the most frequent haplotypes. The mean of A, using the simple regression method, was 4.38 centimorgan (cM). The means of A using the LHS-TDT method were less than the simple regression method in all scenarios and ranged from 1.86 to 3.82 cM depending on the scenario. The mean of A using the combined method was more than the LHS-TDT method and less than the simple regression method. The means of A using the combined method ranged from 2.32 to 4.36 cM. Therefore, for populations similar to those population simulated in this study, the LHS-TDT was better than the simple regression method and the combined method for precision of estimated QTL position in granddaughter designs.  相似文献