Biochemical and molecular effects of a commercial diuretic with herbal extract on experimentally induced urolithiasis in chickens     

Sebaei  Mahmoud G. El  El-Shafei  Reham A.  El-Adl  Mohamed A.  Farag  Amany  Eladl  Abdelfattah H. 《Veterinary research communications》2022,46(2):419-430

Veterinary Research Communications - This study evaluated the diuretic, antioxidant, anti-inflammatory, and immunological effects of a commercial diuretic (CD) (composed of ammonium chloride,...  相似文献   

Biochemical and molecular investigation of oxidative stress associated with urolithiasis induced by increased dietary calcium or protein in chickens     

Mahmoud G. El Sebaei  Nagah Arafat  Reham A. El-Shafei  Mohamed A. El-Adl  Amany Farag  Abeer E. Aziza  Abdelfattah H. Eladl 《Journal of animal physiology and animal nutrition》2021,105(1):129-139

This study was carried out to evaluate the effects of induced urolithiasis by high dietary calcium (Ca) or protein levels on biochemical analyte levels, redox status, selected inflammatory cytokines and histopathology in chickens. A total of 90 one-day-old white Hy-Line chicks were fed basal control diets containing 20% crude protein (CP) and 1% Ca until they reached 44 days of age. After that, the birds were divided into three groups (30 birds per group). All management factors (light, temperature, ventilation, stock density and diet) were identical among the three groups throughout the study except for the dietary Ca and protein percentages. Group I was fed a control diet containing 20% CP and 1% Ca, group II was fed a high-Ca diet containing 5% Ca, and group III was fed a high-protein diet containing 25% CP. Our findings clearly demonstrated that dietary imbalance (caused by high-Ca or high-CP levels) per se in chickens was physiologically harmful, as it was accompanied by post-mortem lesions; biochemical, redox status and histopathological alterations; and upregulation of inflammatory cytokines (interleukin (IL)-1β and IL-6). In particular, the birds fed the high-Ca diet clearly exhibited the most obvious alterations in most of the endpoints. In conclusion, this study constitutes the first extensive investigation of the effects of high-Ca or high-protein diets induced urolithiasis on growth performance, redox status, inflammatory cytokine levels and pathological characterization in chickens.  相似文献