Amoxycillin and clavulanic acid combination in the treatment of experimentally induced bacterial cystitis in cats   总被引：1，自引：0，他引：1  

D F Senior  J M Gaskin  C D Buergelt  P P Franks  T J Keefe 《Research in veterinary science》1985,39(1):42-46

Clavulanic acid (CA) competitively inhibits beta-lactamase hydrolysis of penicillins in vitro. Treatment with amoxycillin combined with clavulanic acid (A-CA) was compared with placebo in a blind study in cats with experimental cystitis caused by Escherichia coli demonstrating in vitro resistance to amoxycillin. Bacterial cystitis was induced in 20 cats by bladder infusion of 5 ml of 0.05 per cent alcoholic salicylic acid followed after 24 hours by a brain-heart infusion broth of E coli (10(8) colony forming units ml-1) previously found to be resistant to amoxycillin in vitro (minimum inhibitory concentration over 512 micrograms ml-1). Four days after infection, cats were randomly divided into two groups of 10 and treated with amoxycillin combined with clavulanic acid or placebo for 10 days. When compared to the placebo-treated group, the A-CA treated group showed: reduced quantitative bacterial counts in urine on days 7 (P less than 0.001) and 14 (P less than 0.02); reduced culture positive urine on days 7 (P less than 0.001) and 14 (P less than 0.001); and less severe inflammation on histological examination of the bladder and urethra (P less than 0.01). It was concluded that A-CA was effective in reducing the bacterial count and reducing the histopathological changes in the bladder and urethra in an experimental model of acute bacterial cystitis in cats infected with an E coli demonstrating in vitro resistance to amoxycillin.  相似文献   

日本锯材市场的变化:工程材和最终产品     

Gerry Van Leeuwen　Senior Consultant 《国际木业》2003,33(11):3

尽管在过去10年里日本集成材的进口取得惊人增长,然而值得注意的是日本本国的结构集成材的生产甚至增长更快.  相似文献   

Barking up the wrong tree: Would international guidelines improve safety in equine anaesthesia?          下载免费PDF全文

J. M. Senior 《Equine veterinary journal》2015,47(1):14-15

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Mitigating the risk of airway obstruction during recovery from anaesthesia: The way is far from clear          下载免费PDF全文

J. M. Senior 《Equine Veterinary Education》2015,27(5):244-246

All equine anaesthetists should take steps to mitigate the risk of anaesthetic‐related morbidities and mortalities where they can, and whilst some interventions against some of these are widely practiced, the number of approaches adopted by equine anaesthetists to mitigate the risk of airway obstruction suggests not only that the causes and severity of airway obstruction vary, but also that evidence for the superiority of any approach over another is limited. The limited evidence available suggests that the prevalence of severe airway obstruction in both the general and upper respiratory tract surgical equine populations is likely to be low, and that when cases do occur, rapid recognition and intervention often results in successful treatment. The above evidence considered with the understanding that pre‐emptively placing endotracheal or nasotracheal tubes in situ for recovery may only delay the recognition of some causes (e.g. laryngeal) of airway obstruction, alongside an awareness that this approach is not a benign risk‐free intervention, may lead some anaesthetists to re‐evaluate the perceived risk of respiratory obstruction and whether their chosen intervention will reduce that risk, potentially exacerbate it or introduce a further risk.  相似文献   

Herbicide-tolerant crops in agriculture: oilseed rape as a case study   总被引：3，自引：0，他引：3  

I. J. Senior  P. J. Dale 《Plant Breeding》2002,121(2):97-107

Oilseed rape has been modified extensively by conventional breeding for the production of varieties useful for human consumption (blended vegetable oil and margarine) and industrial processes (rubber additives and high‐temperature lubricants). Because much is now known about its genetic and biochemical composition, it has been an obvious choice for genetic modification and is now at the forefront of the commercial development of genetically modified (GM) or transgenic crops. Around the world, the increase in commercial plantings of all transgenic crops has been rapid. In 1996, 1.7 million hectares were planted, but by 1998 this figure had jumped to 27.8 million ha. The area in the year 2001 is likely to be about 50 million ha. With the possible introduction of transgenic varieties into European agriculture, it is essential that the associated farming practices employed are appropriate for their growth, both from a commercial and an environmental viewpoint. Some of the first transgenic crops are those carrying agronomic traits, e.g. herbicide tolerance transgenes. However, before full commercialization occurs, important agronomic and environmental questions need to be answered. How are these new crops to be incorporated into existing cropping practices? How will this change the current herbicide use profile for a given crop? Do herbicide‐tolerant varieties enhance or impede integrated pest management schemes? What is the likely uptake of such crops in agriculture? What are the ecological implications of their introduction? Are there effective measures to control the spread of transgenes to wild relatives? This paper addresses these questions, with special emphasis on oilseed rape production in the UK, but includes examples from other crops and countries where appropriate.  相似文献   

ANTHELMINTIC EFFECTS OF PIPERAZINE ON HELMINTHS OF SHEEP     

H. McL. GORDON Senior Principal Research Officer. 《Australian veterinary journal》1955,31(2):52-52

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Post-anaesthetic pulmonary oedema in horses: a review     

Senior M 《Veterinary anaesthesia and analgesia》2005,32(4):193-200

OBJECTIVES: To review information on the pathogenesis, diagnosis and treatment of post-anaesthetic pulmonary oedema in horses. DATABASES USED: Pubmed 1970-present, personal files.  相似文献   

AAHA senior care guidelines for dogs and cats     

Senior Care Guidelines Task Force  AAHA  Epstein M  Kuehn NF  Landsberg G  Lascelles BD  Marks SL  Schaedler JM  Tuzio H 《Journal of the American Animal Hospital Association》2005,41(2):81-91

This paper provides a working framework for enhancing the well-being of senior pet dogs and cats. Approaches to screening the medical status of senior pets are described in detail, with particular emphasis on establishing baseline data in healthy animals, the testing of clinically ill animals, and assessing senior pets prior to anesthesia and surgery. The management of pain and distress and the application of hospice and palliative care are addressed. Advice on ways to approach euthanasia and dealing with end-of-life issues is also provided.  相似文献   

Copper Poisoning In Sheep          下载免费PDF全文

V. E. Senior 《Canadian journal of veterinary research》1959,23(7):229-232

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Prospective evaluation of postoperative pain in cats undergoing ovariohysterectomy by a midline or flank approach     

Burrow R  Wawra E  Pinchbeck G  Senior M  Dugdale A 《The Veterinary record》2006,158(19):657-660

Twenty entire female cats were randomly assigned to two groups of 10; the cats in one group underwent ovariohysterectomy by a midline approach and the cats in the other group by a flank approach. Cats were assessed for signs of pain and scores were assigned pre- and postoperatively. There was a tendency for the cats neutered by a flank approach to be in more pain postoperatively (P=0.05). The final pain score for cats in either group was equal to or lower than their baseline score.  相似文献