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Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs 总被引：1，自引：0，他引：1
Sevinc F Turgut K Sevinc M Ekici OD Coskun A Koc Y Erol M Ica A 《Veterinary parasitology》2007,149(1-2):65-71
The objective of this study was to evaluate the therapeutic and prophylactic efficacy of imidocarb dipropionate (IMDP) against babesiosis and to determine specific antibodies against Babesia ovis in experimentally infected lambs. Thirty-six 6-month-old splenectomized lambs were used. The lambs were randomly divided into six groups with six animals each, and were intravenously inoculated with 50 mL B. ovis-infected erythrocytes as follows: group I (therapy group) was treated with IMDP (1.2 mg/kg body weight) starting on the day of onset of clinical signs of babesiosis after the inoculation; group II (untreated control animals) was not treated with any therapeutic treatment after the inoculation; groups III, IV, V and VI (prophylaxis groups) were administered IMDP (2.4 mg/kg body weight) 1, 2, 3 and 4 weeks before the inoculation, respectively. The animals were housed in a tick-proof room with water and food ad libitum up to the 30th day post-inoculation (PI). The lambs were monitored from the first day PI by recording the manifestation of clinical disease, rectal temperature, and the degree of parasitaemia. All the lambs became infected with B. ovis, except five animals from group III, which were treated 1 week prior to experimental infection. Other animals showed signs of acute clinical babesiosis. The animals treated with IMDP (group I) were able to clear the parasite from the blood circulation after 48 h post-treatment. The recrudescence of B. ovis was observed in two lambs 7 days after treatment, and they were treated with the second similar dose of the drug. Six lambs (1, 1, 2 and 2 lambs in group III, IV, V and VI, respectively) from the prophylaxis groups died within 7-17 days after showing high parasitaemia and clinical symptoms of the disease. Regardless of the clinical symptoms, 83.30% and 66.66% of the lambs which were administered IMDP 1-2 and 3-4 weeks before, were determined to be protected against the virulent field strain of B. ovis. 相似文献
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Ahmet Kursat Azkur Harun Albayrak Ali Risvanli Zuleyha Pestil Emre Ozan Oktay Yılmaz Sukru Tonbak Abdullah Cavunt Hamza Kadı Hasan Ceyhun Macun Duygu Acar Erhan Özenç Sidal Alparslan Hakan Bulut 《Tropical animal health and production》2013,45(8):1825-1828
This, partly retrospective study, was designed to determine the seroprevalence of Schmallenberg virus (SBV), a new Orthobunyavirus first reported in Germany in late 2011, in domestic ruminants from the Middle Black Sea, West, and Southeast regions of Turkey. An indirect enzyme-linked immunosorbent assay was used to screen serum samples collected from slaughterhouse animals between 2006 and 2013. The overall seroprevalence was 335/1,362 (24.5 %) with 325/816 (39.8 %), 5/307 (1.6 %), 3/109 (2.8 %), and 2/130 (1.5 %) recorded in cattle, sheep, goats, and Anatolian water buffalo, respectively. This is the first study to demonstrate the presence of antibodies to SBV in Turkish ruminants; it indicates that cattle are more susceptible to infection than sheep, goats, or buffalo and that exposure of domestic ruminants to SBV in Turkey may have occurred up to 5 years prior to the first recorded outbreak of the disease in 2011. 相似文献
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Toxic effects of the wastewater were investigated ultrastructurally in root tips of Triticum aestivum. As a result, wall and nuclear degradations, disruptions in all cytoplasmic membranes, irregular nucleus shapes and cellular organization defects were densely detected. Besides, germination ratio, total protein contents, DNA contents and root-shoot growth were found to be decreased significantly when compared to the control group. Results were compared with those of recent studies regarding excessive Na+, Fe+2, P, polyphenols and acidic pH toxicity. 相似文献
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Mahmut Sozmen Alparslan Kadir Devrim Recai Tunca Murat Bayezit Serpil Dag Dinc Essiz 《Journal of veterinary science (Suw?n-si, Korea)》2014,15(1):51-60
The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B1 (FB1) in BALB/c mice. The mice were divided into six groups (n = 15). Group 1 served as the control. Group 2 was the silymarin control (100 mg/kg by gavage). Groups 3 and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1, intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5 received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), and Group 6 was given a higher dose of FB1 (4.5 mg/kg FB1) with silymarin (100 mg/kg). Silymarin treatment significantly decreased (p < 0.0001) the apoptotic rate. FB1 administration significantly increased (p < 0.0001) proliferating cell nuclear antigen and Ki-67 expression. Furthermore, FB1 elevated the levels of caspase-8 and tumor necrosis factor-alpha mediators while silymarin significantly reduced (p < 0.0001) the expression of these factors. Vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) expressions were significantly elevated in Group 4 (p < 0.0001). Silymarin administration alleviated increased VEGF and FGF-2 expression levels (p < 0.0001). In conclusion, silymarin ameliorated toxic liver damage caused by FB1 in BALB/c mice. 相似文献
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The aim of this study is to assess the effects of Olive Oil Mill Wastewater (OOMW) application as irrigation water on in vitro pollen germination, focusing on total protein quantity. In test groups, pollen germination substances such as sucrose, H3BO3 and Ca(NO3)2 were added to different concentrations of OOMW and used as germination media. Regarding control group, the same substance melted into water instead of OOMW. As a result, in general, pollen germination percentage was decreased significantly in all OOMW concentrations than that of the control group, except 1/1000 concentrations. Similarly, total protein quantities declined linearly depending on decreasing OOMW concentrations, except 1/1 concentration which has 4-5 times the control value. Consequently, it was established that OOMW generally decreased pollen germination ratio and had carcinogenic effects on protein synthesis mechanism and must not be used as irrigation water without purification. 相似文献
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A. Müezzinoğlu D. Sponza I. K Ken N. Alparslan A. Akyarli N. Zt Re 《Water, air, and soil pollution》2000,123(1-4):245-257
The city of ?zmir on the Aegean Sea shoreline is suffering from rotten odors emitted by anoxic river mouths. Anaerobic conditions in the shallowest portion of ?zmir Bay due to industrial and domestic wastewaters as well as eutrophication products in this very calm part of the Bay are responsible for this. The inner section of the Bay is becoming shallower with sediments rich in organic matter. Aerobic digestion of organic pollutants is limited by the oxygen input and the warm climate leads to an optimal medium for anaerobic processes when anoxic conditions take over. Anaerobic digestion products are odorous gases among which H2S with a characteristic pungent odor is most effective in this case. Sulfur containing gases are formed from sulfides and sulfates in the sediment-water interface and are released into the air. Airborne H2S concentrations are variable as they depend on factors such as high atmospheric diffusion coefficients under changing wind direction and speed, as well as variable such as water depths, organic loadings from rivers, air and water temperatures, sulfate concentrations in sediment and water phases, pH, and Eh. This study aimed to control noxious smells by inhibiting the anaerobic sulfate-reducing bacteria at the sediment surface. To achieve this aim, pH of the sediment-water interface was increased by spreading hydrated lime. Successful lime doses were investigated in laboratory models first and were then tested and applied in the estuary and downstream segment of one of the creeks. Rates of H2S gas emissions and aqueous H2S levels were measured. It was noted that waterborne H2S levels at river mouths were reduced. Odor control efficiencies of 80–96% even after 10 days of lime addition in the field experiments were obtained. Therefore, the results of this study indicated that lime application to the sediment surface is a recommended method in odor control programs. 相似文献
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