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Soo-Young CHOI Woo-Chang JEONG Young-Won LEE Ho-Jung CHOI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(2):239-244
Contrast enhanced ultrasound (CEUS) is useful to evaluate tissue perfusion in the kidney. In veterinary
medicine, sedation or anesthesia may be required in uncooperative or panting patients. The aim of this study
was to evaluate and compare the normal kidney perfusion patterns in conscious and anesthetized dogs using
CEUS. Eight healthy beagles were used in this study. Scanning was performed in conscious dogs using manual
restraint (conscious group), or under general anesthesia using tiletamine-zolazepam and medetomidine (TZM
group) or medetomidine (M group). The contrast agent (Sonovue®) was administered as an IV bolus.
The peak intensity (PI), time to peak enhancement from injection (TTP0) and the time to peak
enhancement from the initial rise (TTPup), upslope, downslope and area under the curve (AUC) were
analyzed. Compared to the cortical values in the conscious group, TTP0 was significantly delayed in
the TZM group, and upslope, TTP0 and TTPup were significantly different in the M group.
The AUCs in the TZM and M groups were not different from those in the conscious group. The upslope of renal
medullary perfusion was significantly decreased in the TZM and M groups. TTP0 and TTPup
were also significantly delayed in these groups. The AUC of the medulla was significantly decreased in the M
group. Therefore, TZM is useful as an anesthetic protocol when performing CEUS, and the obtained data may
serve as reference values in the evaluation of renal perfusion using CEUS in dogs under anesthesia. 相似文献
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Soo-Young CHOI Ho-Jung CHOI Ki-Ja LEE Young-Won LEE 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(9):1049-1054
To establish a protocol for a multi-phase computed tomography (CT) of the
canine pancreas using the bolus-tracking technique, dynamic scan and multi-phase CT were
performed in six normal beagle dogs. The dynamic scan was performed for 60 sec at 1-sec
intervals after the injection (4 ml/sec) of a contrast medium, and
intervals from aortic enhancement appearance to aortic, pancreatic parenchymal and portal
vein peaks were measured. The multi-phase CT with 3 phases was performed three times using
a bolus-tracking technique. Scan delays were 0, 15 and 30 in first multi-phase scan; 5, 20
and 35 in second multi-phase scan; and 10, 25 and 40 sec in third multi-phase scan,
respectively. Attenuation values and contrast enhancement pattern were analyzed from the
aorta, pancreas and portal vein. The intervals from aortic enhancement appearance to
aortic, pancreatic parenchymal and portal vein peaks were 3.8 ± 0.7, 8.7 ± 0.9 and 13.3 ±
1.5 sec, respectively. The maximum attenuation values of the aorta, pancreatic parenchyma
and portal vein were present at scan sections with no scan delay, a 5-sec delay and a
10-sec delay, respectively. When a multi-phase CT of the canine pancreas is triggered at
aortic enhancement appearance using a bolus-tracking technique, the recommended optimal
delay times of the arterial and pancreatic parenchymal phases are no scan delay and 5 sec,
respectively. 相似文献
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The multi-walled carbon nanotube (MWNT)/cellulose nanocomposites were prepared by using monohydrated Nmethylmorpholine-N-oxide (NMMO) as a solvent for dispersing the acid-treated MWNTs (A-MWNTs) as well as for dissolving the cellulose. The A-MWNTs were well dispersed in both monohydrated NMMO and the nanocomposite films. The nanocomposite films were prepared by a film-casting method onto a glass plate. The tensile strain at break, Young’s modulus, and toughness of nanocomposite films increased by ～5, ～2 and ～12 times, respectively at ? (A-MWNT content in the nanocomposite)=0.8 wt%, as compared to those of the pure cellulose film. The thermal degradation temperature of the nanocomposite films also increased from 329 to 339 oC by incorporation of 1 wt% A-MENTs. The electric conductivities of the A-MWNT/cellulose nanocomposites at ? =1 and 10 wt% were 2.09×10?5 and 3.68×10?3 S/cm, respectively. The transmittances were 86, 69 and 55 % at 550 nm for 0.4, 0.8 and 1 wt% nanocomposite films, respectively. Thus, these nanocomposites are promising materials in terms of all the properties studied in this paper and can be used for many applications, such as toughened cellulose fibers, transparent electrodes, etc. 相似文献
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Young Myong Kang Heui Man Kim Keun Bon Ku Eun Hye Park Jung Yum Sang Heui Seo 《Veterinary research》2013,44(1):92
Dogs are companion animals that live in close proximity with humans. Canine H3N2 influenza virus has been isolated from pet dogs that showed severe respiratory signs and other clinical symptoms such as fever, reduced body weight, and interstitial pneumonia. The canine H3N2 influenza virus can be highly transmissible among dogs via aerosols. When we analyzed global gene expression in the lungs of infected dogs, the genes associated with the immune response and cell death were greatly elevated. Taken together, our results suggest that canine H3N2 influenza virus can be easily transmitted among dogs, and that severe pneumonia in the infected dogs may be partially due to the elevated expression of genes related to inflammation and apoptosis. 相似文献
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Seungil Yum 《Growth and change》2020,51(3):1017-1044
This study highlights the association between minority racial/ethnic groups and travel mode choices according to a multitude of neighborhood characteristics, travel modes, and purposes in the Delaware Valley region. This study finds that minority racial/ethnic groups show different travel mode choices than whites. For instance, Blacks and Hispanics are less inclined to walk/bike, whereas whites prefer to use household carpool in high density areas when they go home. This study also highlights that minority racial/ethnic groups choose different travel modes according to travel purposes. For instance, blacks in ethnic neighborhoods are less inclined to use household carpool, whereas Asians are more apt to use it for the purpose of home. The results show that urban planners should design transportation policies for minority groups based on race/ethnicity, neighborhood characteristics, and travel purposes. 相似文献
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The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the procedure.However, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle. 相似文献
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