排序方式： 共有8条查询结果，搜索用时 15 毫秒
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Bianca Ferreira Olivieri Camila Urbano Braz Fernando Brito Lopes Elisa Peripolli Rafael Medeiros de Oliveira Silva Rosana Ruegger Pereira da Silva Corte Lucia Galvo de Albuquerque Anglica Simone Cravo Pereira Nedenia Bonvino Stafuzza Fernando Baldi 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2021,138(1):80-90
The aim of this study was to identify differentially expressed genes (DEG) in the Longissimus thoracis muscle of Nelore cattle related to fatty acid (FA) profile through RNA sequencing and principal component analysis (PCA). Two groups of 10 animals each were selected containing PC1 and PC2 extreme DEG values (HIGH × LOW) for each FA group. The intramuscular fat (IMF) was compared between cluster groups by ANOVA, and only the sum of monounsaturated FA (MUFA) and ω3 showed significant differences (p < .05). Interestingly, the highest percentage (95%) of phenotypic variation explained by the sum of the first two PC was observed for ω3, which also displayed the lowest number of DEG (n = 1). The lowest percentage (59%) was observed for MUFA, which also revealed the largest number of DEG (n = 66). Since only MUFA and ω3 exhibited significant differences between cluster groups, we can conclude that the differences observed for the remaining groups are not due to the percentage of IMF. Several genes that have been previously associated with meat quality and FA traits were identified as DEG in this study. The functional analysis revealed one KEGG pathway and eight GO terms as significant (p < .05), in which we highlighted the purine metabolism, glycolytic process, adenosine triphosphate binding and bone development. These results strongly contribute to the knowledge of the biological mechanisms involved in meat FA profile of Nelore cattle. 相似文献
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Nedenia Bonvino Stafuzza Eliane Vianna da Costa e Silva Rafael Medeiros de Oliveira Silva Luiz Carlos Cesar da Costa Filho Fernanda Battistotti Barbosa Gustavo Guerino Macedo Raysildo B. Lobo Fernando Baldi 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2020,137(2):234-244
Selection for bulls that would reach puberty early reduces the generation interval and increases fertility and herd productivity. Despite its economic importance, there are few QTL associated with age at puberty described in the literature. In this study, a weighted single-step genome-wide association study was performed to detect genomic regions and putative candidate genes related to age at puberty in young Nelore bulls. Several protein-coding genes related to spermatogenesis functions were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for age at puberty in Nelore bulls, such as ADAM11, BRCA1, CSNK2A, CREBBP, MEIOC, NDRG2, NECTIN3, PARP2, PARP9, PRSS21, RAD51C, RNASE4, SLX4, SPA17, TEX14, TIMP2 and TRIP13 gene. Enrichment analysis by DAVID also revealed several GO terms related to spermatogenesis such as DNA replication (GO:0006260), male meiosis I (GO:0007141), double-strand break repair (GO:0006302), base excision repair (GO:0006284), apoptotic process (GO:0006915), cell–cell adhesion (GO: 0098609) and focal adhesion (GO:0005925). The heritability for age at puberty shows that this trait can be improved based on traditional EBV selection. Adding genomic information to the system helps to elucidate genes and molecular mechanisms controlling the sexual precocity and could help to predict sexual precocity in Nelore bulls with greater accuracy at younger age, which would speed up the breeding programme for this breed. 相似文献
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Freitas Ana C. Stafuzza Nedenia B. Barbero Marina M. D. Santos Daniel J. A. Fortes Marina R. S. Tonhati Humberto 《Tropical animal health and production》2020,52(1):415-423
Tropical Animal Health and Production - Animal breeding programs have used molecular genetic tools as an auxiliary method to identify and select animals with superior genetic merit for milk... 相似文献
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Luara Afonso de Freitas Rodrigo Pelicioni Savegnago Natalia Vinhal Grupioni Salvador Boccaletti Ramos Nedenia Bonvino Stafuzza Elsio Antônio Pereira de Figueiredo 《Acta Agriculturae Scandinavica, Section A - Animal Sciences》2018,68(2):81-86
The aims of this study were to compare the suitability of the multi-trait (MUT) model to estimate genetic parameters with that of 13 reduced-rank principal component models (PC1 to PC13), and then to explore the additive genetic patterns of the breeding values obtained from these using clustering analyses of egg production traits. A total of 1,212 records were used to estimate genetic parameters using the MUT and PC models. The PC4 model was the best representation of the data since it had a lower AIC value and was more parsimonious than the MUT model. The estimated heritability of the age at the first egg (AFE) trait from this model was 0.28?±?0.06, and the estimated genetic correlation between AFE and total egg production (TP) was ?0.52?±?0.23. Potentially animals from cluster 2 are more likely to be in the selected group to help improve the egg production. 相似文献
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Lima Sergio B. G. P. N. P. Stafuzza Nedenia Bonvino Pires Bianca V. Bonilha Sarah F. M. Cyrillo Joslaine N. S. G. Negrão João A. Paz Claudia C. P. 《Tropical animal health and production》2020,52(5):2233-2241
The climate-related problems that affect animal production in tropical countries have encouraged seeking solutions to increase herd productivity and one alternative is the use of breeds adapted to high-temperature environments. The objective of this study was to evaluate the effect of temperature on 77 Caracu and Nelore males submitted to three different environments: morning period (8:00 to 10:00 AM), afternoon in the sun, and afternoon in a shaded environment (11:00 AM to 1:00 PM). The following physiological parameters were measured in each treatment: heart and respiration rates, rectal and dorsal surface temperatures, and cortisol level. The data were analyzed with the MIXED procedure (SAS) and the model included the fixed effects of treatment (morning, sun, and shade), breed (Nelore and Caracu), month of measurement (December and February), and the interaction between effects. A higher dorsal surface temperature was observed in animals of both breeds in the sun treatment compared with the shade treatment. Caracu animals had a higher dorsal surface temperature than Nelore animals, which probably caused the higher rectal temperature observed in the sun treatment compared with the shade treatment in both breeds over the 2 months of the study. All physiological parameters measured in this study were efficient to detect the thermal stress in both breeds. Despite the variations in rectal temperature observed during the treatments, the animals of the two breeds exhibited no significant changes in heart rate, respiration rate, and cortisol level for the maintenance of thermal homeostasis. In conclusion, both breeds were considered tolerant to sun exposure, demonstrating adaptation of these animals to high-temperature environments, without evidence of harm to its health and welfare.
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Elisa Peripolli Nedenia Bonvino Stafuzza Sabrina Thaise Amorim Marcos Vinícius Antunes de Lemos Laís Grigoletto Sabrina Kluska José Bento Sterman Ferraz Joanir Pereira Eler Elisângela Chicaroni Mattos Fernando Baldi 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2020,137(2):155-165
The aim of this study was to assess the distribution of runs of homozygosity (ROH) and autozygosity islands in the composite Montana Tropical® beef cattle to explore hotspot regions which could better characterize the different biological types within the composite breed. Montana animals (n = 1,436) were genotyped with the GGP-LD BeadChip (~30,000 markers). ROH was identified in every individual using the plink v1.90 software. Medium and long ROH prevailed in the genome, which accounted for approximately 74% of all ROH detected. On an average, 2.0% of the genome was within ROH, agreeing with the pedigree-based inbreeding coefficient. The Montana cattle with a higher proportion of productive breed types showed the highest number of autozygosity islands (n = 17), followed by those with a higher proportion of breeds adapted to tropical environments (n = 15). Enriched terms (p < .05) associated with the immune and inflammatory response, homeostasis, reproduction, mineral absorption, and lipid metabolism were described within the autozygosity islands. In this regard, over-represented GO terms and KEGG pathways described in this population may play a key role in providing information to explore the genetic and biological mechanisms together with the genomic regions underlying each biological type that favoured their optimal performance ability in tropical and subtropical regions. 相似文献
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Ludmilla C. Brunes Fernando Baldi Fernando B. Lopes Raysildo B. Lbo Rafael Espigolan Marcos F. O. Costa Nedenia B. Stafuzza Cludio U. Magnabosco 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2021,138(1):23-44
The aim was to conduct a weighted single‐step genome‐wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein‐coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways (p‐value < .05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int‐1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE‐related traits. 相似文献
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