FC-17 Cutaneous papillomatosis and carcinomatosis in the highly endangered Western Barred Bandicoot   总被引：1，自引：0，他引：1  

A. J.O''hara  K. S.Warren  R. A.Swan  C.Simms  J. A.Friend 《Veterinary dermatology》2004,15(S1):25-25

Newcastle disease virus (NDV) has antineoplastic and immunostimulatory properties, and it is currently being clinically tested in anticancer therapy. In order to analyse the immunostimulatory effects of NDV on bovine papillomatosis, we inoculated 14 cows subcutaneously with an attenuated vaccine containing the LaSota strain of NDV (LS-NDV). Four cows with papillomatosis served as controls. Serum samples were collected from each animal 1 h preinoculation and 7 and 21 days postinoculation. In inoculated cows on days 7 and 21, the mean antibody titres were log₂ 2.43 ± 0.92 and 5.57 ± 0.72, respectively, by haemagglutination inhibition, and the mean levels of TNFα were 5.80 ± 4.19 and 5.39 ± 2.66 ng/mL, respectively, by WEHI-164 cytotoxicity assay. Significant differences between inoculated and control animals were evident for antibody titres on day 21 and clinical scores on day 60. A correlation was evident between the TNFα activities and clinical scores on day 21. The clinical observations at day 60 showed that the papillomas in five cows had completely resolved (36%), one animal had no alterations on clinical appearance of the tumour (7%), and papillomas in eight cows had regressed (57%). In conclusion, these results demonstrated that inoculation of LS-NDV vaccine stimulates an antibody response and a limited increase in TNFα activity and may enhance clinical recovery in bovine papillomatosis.
Funding: Scientific Research Council of Akdeniz University.  相似文献   

Outcome of reconstruction of cutaneous limb defects in dogs using hygroscopic “self‐inflating” tissue expanders          下载免费PDF全文

M. De Lorenzi  M. C. Swan  C. Easter  G. P. A. Chanoit 《The Journal of small animal practice》2018,59(2):98-105

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The toxic effect of massive doses of calciferol on dairy cows     

J.B. Swan B.V.Sc. 《New Zealand veterinary journal》2013,61(2):25-27

Extract

Evidence that feeding massive doses, of calciferol prior to calving may be a useful method of preventing milk fever was obtained by Hibbs and co-workers (1950, 1951) at Ohio State University. The treatment causes a rise in serum calcium and if dosing is suitably timed the post-partum fall in serum calcium may be countered, thus making up for the presumed parathyroid failure which occurs at this lime and which is believed by many to be the underlying cause of milk fever.  相似文献   

Relative bioavailability of rafoxanide following intraruminal and intra-abomasal administration in sheep     

Swan GE  Koeleman HA  Steyn HS  Mülders MS 《Journal of the South African Veterinary Association》1999,70(2):71-74

The bioavailability of rafoxanide was compared after intraruminal and intra-abomasal administration in healthy adult sheep (n = 6) in a single dose, 2 parallel group study at 7.5 mg/kg. Rafoxanide concentrations in plasma were measured by means of HPLC analysis. Primary pharmacokinetic parameters for bioavailability and disposition of rafoxanide in plasma for both routes of administration were determined by non-compartmental and non-linear, 1-compartmental pharmacokinetic analysis, respectively. Significantly (P < or = 0.05) higher peak plasma concentrations (c(max)) of rafoxanide and a more rapid rate of absorption (c. 3.5 times) was observed in sheep after intra-abomasal (i-a) administration compared to intraruminal (i.r.) administration. A significantly (P < or = 0.05) longer lag period (t(lag)) before absorption (6.8 +/- 2.9 h) occurred after i.r. than after i-a treatment (1.9 +/- 0.6 h). There was no significant difference (P > 0.05) in AUC, MRT and in the rates of elimination (k10-HL and t(1/2beta)) between the i.r. and i-a routes of administration. The results of the study demonstrated the important influence of the rumino-reticulum on absorption of rafoxanide in sheep.  相似文献   

Cryptosporidium muris infection in bilbies (Macrotis lagotis)     

Warren KS  Swan RA  Morgan-Ryan UM  Friend JA  Elliot A 《Australian veterinary journal》2003,81(12):739-741

Cryptosporidiosis is an enteric disease of animals and humans that can be fatal in immunocompromised individuals. There is no known effective treatment for cryptosporidiosis. Bilbies are threatened marsupials and are bred in captivity as part of a recovery program to re-introduce this species to the southwest of Western Australia. Cryptosporidium muris infection was detected in the faeces of bilbies at a captive breeding colony. Stress associated with a high density of bilbies in enclosures may have predisposed some of the bilbies to infection with C. muris. C. muris has been described in mice and was found in the faeces of one mouse trapped in the breeding enclosures. It is likely the bilbies acquired the infection from mice by faecal contamination of food and water. The infection cleared within 2 months from some bilbies, however others remained infected for 6 months and treatment was attempted with dimetridazole. Subsequently the parasite was no longer be detectable in the faeces.  相似文献   

Screening of five drugs for efficacy against Babesia felis in experimentally infected cats     

Penzhorn BL  Lewis BD  López-Rebollar LM  Swan GE 《Journal of the South African Veterinary Association》2000,71(1):53-57

The efficacy of 5 drugs was tested against experimental Babesia felis infection in domestic cats. Two of the drugs, rifampicin and a sulphadiazine-trimethoprim combination, appeared to have an anti-parasitic effect, but were inferior to primaquine. The other 3 drugs, buparvaquone, enrofloxacin and danofloxacin, had no significant anti-babesial effect.  相似文献   

Control of perineal squamous cell carcinoma in ewes     

R A Swan  C D Hawkins  H M Chapman 《Australian veterinary journal》1985,62(S1):143-143

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Efficacy of ivermectin against induced gastrointestinal nematode infections in goats     

G E Swan  S J Gross 《The Veterinary record》1985,117(7):147-149

The efficacy of ivermectin (0.08 per cent w/v oral solution) at different dose levels was evaluated against induced infections of adult Haemonchus contortus (21 days old) and Trichostrongylus colubriformis (21 days old) and fourth stage larvae of Oesophagostomum columbianum (17 days old), Ostertagia circumcincta (five days old) and Strongyloides papillosus (five days old). Twenty-five Boergoats (mutton goats) were randomly allocated by bodyweight within each sex to an untreated control group and four ivermectin treatment groups; ivermectin was administered at either 25, 50, 100 or 200 micrograms/kg orally, once. The goats were killed and processed for worm recovery 25 to 27 days after treatment. At 25 micrograms/kg the efficacy of ivermectin varied from 43 per cent for adult T colubriformis to more than 99 per cent for fourth larval stage O columbianum. Ivermectin at 50 micrograms/kg or higher was 99 per cent or more effective against all induced parasite infections with the exception of ivermectin at 50 micrograms/kg against S papillosus (97 per cent). For all parasites there was a statistically significant (P less than 0.05) difference between the control group and the pooled treated groups. No adverse reactions to ivermectin treatment were observed in the goats.  相似文献   

COMPUTED TOMOGRAPHIC AND ULTRASONOGRAPHIC CHARACTERISTICS OF CAVERNOUS TRANSFORMATION OF THE OBSTRUCTED PORTAL VEIN IN SMALL ANIMALS          下载免费PDF全文

Swan Specchi  Pascaline Pey  Gianluca Ledda  Meghann Lustgarten  Donald Thrall  Giovanna Bertolini 《Veterinary radiology & ultrasound》2015,56(5):511-519

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Comparison of some selection procedures and objectives in faba beans (Vicia faba L.). I. direct and index selection for seed yield     

D. L. C. Brinkhorst Van Der Swan  A. Ph. De Vries 《Euphytica》1986,35(3):793-808

Summary Starting with two heterogeneous F₂ populations, each based on 20 cross combinations, different selection procedures were applied for four consecutive selection cycles. Three of the selection procedures involved seed yield per plant (SYP): (i) direct selection for SYP (DSY); (ii) indexselection for SYP (ISY) with plant length, the ratio of the vegetative top to plant length, end of grain filling and duration of the generative stage as auxiliary characters and finally; (iii) independent culling levels selection (ICL) for the index described above and crude protein content. For ICL-selection the attention is focussed on SYP in this paper.For all three selection procedures, predicted and realized responses were calculated and expressed as percentage of a corresponding non-selected population. The intensities of selection differed over selection methods and generations, mostly due to practical constraints.As far as predicted responses are concerned, ISY-selection seemed to be slightly superior to DSY-selection and DSY-selection to ICL-selection. This order may partly be due to differences in selection intensity. However, none of the predictions was very accurate, but the predictions of ICL-selection seemed to be the most accurate. This has been ascribed also to the relative mild selection intensity applied in ICL-selection. It is concluded that a decision in favour of a complicated selection procedure like index selection based on predicted responses only cannot be defended. As far as realized responses are concerned, DSY-selection seems to be slightly superior to the other two selection procedures, as it is the only procedure that resulted in a more or less stable positive response to selection.The auxiliary characters, especially plant length, showed a marked correlated response to all three selection procedures. In case of direct selection for SYP this seemed paradoxical with the inefficiency of index selection, but, it may reflect the differences in the genuine genotypic correlations and the estimated genotypic correlations.  相似文献