Necropsy findings of koalas from the Mount Lofty Ranges population in South Australia          下载免费PDF全文

KN Speight  P Hicks  C Graham  W Boardman  WG Breed  E Manthorpe  O Funnell  L Woolford 《Australian veterinary journal》2018,96(5):188-192

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Pharmacokinetics and bioequivalence of parenterally administered doramectin in cattle   总被引：3，自引：1，他引：2  

M.A. NOWAKOWSKI  M.J. LYNCH  D.G. SMITH  N.B. LOGAN†  D.E. MOUZIN†  J. LUKASZEWICZ  N.I. RYAN  R.P. HUNTER  R.M. JONES 《Journal of veterinary pharmacology and therapeutics》1995,18(4):290-298

Plasma concentrations of doramectin in 40 cattle dosed by subcutaneous (sc) or intramuscular (i.m.) injection (200 μg/kg) were compared to assess the bioequivalence of the two routes of administration. Peak concentration ( C _max), and areas under the concentration curve ( AUC_0– ) were determined from plasma concentrations. Animals treated by the sc route showed a mean AUC_0– of 457 ± 66 ng±day/mL (± SD) and a mean C _max of 27.8 ± 7.9 ng/mL. Results from the i.m. treatment group showed a mean AUC _0– of 475 ± 82 ng-day/mL and a mean C _max of 33.1 ± 9.0 ng/mL Absorption constants ( k _a) determined by modelling were 0.542 ± 0.336 day^-1after sc administration and 0.710 ± 0.357 day^-1after i.m. administration. The 90% confidence limits on the difference between mean AUC _0– values for the sc and i.m. groups fell within 20% of the mean value for the subcutaneous group. C _max was somewhat greater for the i.m. route. The 90% confidence limits on the difference in mean In ( T _max+1) also fell within 20% of the mean sc value. Based on this analysis, bioequivalence of the sc and i.m. formulation has been established.  相似文献   

Formation of Chiral Interdigitated Multilayers at the Air-Liquid Interface Through Acid-Base Interactions     

I Kuzmenko  R Buller  WG Bouwman  K Kjaer  J Als-Nielsen  M Lahav  L Leiserowitz 《Science (New York, N.Y.)》1996,274(5295):2046-2049

Thin interdigitated films composed of a long-chain, water-insoluble chiral acid (p-pentadecylmandelic acid of absolute configuration R) and a water-soluble chiral base (phenylethylamine, R') were constructed at the air-solution interface. The (R, R') structure was characterized to near-atomic resolution by grazing-incidence x-ray diffraction (GIXD). The two diastereomeric systems, (R, R') and (R, S'), demonstrate similar surface pressure-molecular area isotherms, but their structures are completely different on the molecular level, as monitored by GIXD. Complementary data on these two architectures were provided by atomic force microscopy.  相似文献   

Production of pharyngoconjunctival fever in human volunteers inoculated with APC viruses     

WARD TG  HUEBNER RJ  ROWE WP  RYAN RW  BELL JA 《Science (New York, N.Y.)》1955,122(3179):1086-1087

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Glucuronidase activation: enzyme action at an interface     

RYAN MT  MAVRIDES CA 《Science (New York, N.Y.)》1960,131(3393):101-102

Although the rate of hydrolysis by mammalian beta-glucuronidase appears to be inhibited by methylene chloride or carbon tetrachloride with the standard technique (phenolphthalein glucuronide as a substrate), the release of steroidal conjugates under conditions generally employed does not appear to be affected.  相似文献   

Leukocyte counts in the blood from the tail and the heart of the mouse     

GOLDIE H  JONES AM  RYAN H  SIMPSON M 《Science (New York, N.Y.)》1954,119(3089):353-354

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The need to implement the landscape of fear within rodent pest management strategies          下载免费PDF全文

Inge M Krijger  Steven R Belmain  Grant R Singleton  Peter WG Groot Koerkamp  Bastiaan G Meerburg 《Pest management science》2017,73(12):2397-2402

Current reactive pest management methods have serious drawbacks such as the heavy reliance on chemicals, emerging genetic rodenticide resistance and high secondary exposure risks. Rodent control needs to be based on pest species ecology and ethology to facilitate the development of ecologically based rodent management (EBRM). An important aspect of EBRM is a strong understanding of rodent pest species ecology, behaviour and spatiotemporal factors. Gaining insight into the behaviour of pest species is a key aspect of EBRM. The landscape of fear (LOF) is a mapping of the spatial variation in the foraging cost arising from the risk of predation, and reflects the levels of fear a prey species perceives at different locations within its home range. In practice, the LOF maps habitat use as a result of perceived fear, which shows where bait or traps are most likely to be encountered and used by rodents. Several studies have linked perceived predation risk of foraging animals with quitting‐harvest rates or giving‐up densities (GUDs). GUDs have been used to reflect foraging behaviour strategies of predator avoidance, but to our knowledge very few papers have directly used GUDs in relation to pest management strategies. An opportunity for rodent control strategies lies in the integration of the LOF of rodents in EBRM methodologies. Rodent management could be more efficient and effective by concentrating on those areas where rodents perceive the least levels of predation risk. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.  相似文献   

Effect of body condition score and reuse of progesterone‐releasing intravaginal devices on conception rate following timed artificial insemination in Nelore cows          下载免费PDF全文

LL Pereira  AP Ferreira  WG Vale  LR Serique  KAL Neves  AC Morini  BM Monteiro  AHH Minervino 《Reproduction in domestic animals》2018,53(3):624-628

This study had the aim of investigating the efficiency of timed artificial insemination (TAI) through the progesterone‐releasing intravaginal device (PRID), used in new condition and for the second and third times in Nelore cows. The effects of device reuse and body condition score (BCS) on the conception rate (CR) were evaluated in 1,122 multiparous Nelore cows (mean BCS of 2.7 ± 0.4), which were randomly distributed into three groups that received new (n = 330), once (n = 439) and twice used (n = 353) PRID. Among the 1,122 females that underwent TAI, 573 became pregnant, thus representing an overall CR of 51.06%. Cows with BCS between 2.75 and 4.0 had greater (p < .0001) CR (69.75%) than cows with BSC of 2.0–2.5 (32.98%). It was observed that the CR through using PRID was 60.00%, 51.71% and 41.93% for new, once and twice used PRID, respectively, with difference between all groups (p < .0001). Under tropical conditions, animals with BCS greater than 2.5 had a higher CR, and the CR decreased proportionally with the number of times that the PRID had been used.  相似文献   

Arthrodesis of the Equine Proximal Interphalangeal Joint: A Biomechanical Comparison of Two Parallel Headless, Tapered, Variable-Pitched, Titanium Compression Screws and Two Parallel 5.5 mm Stainless-Steel Cortical Screws     

RYAN R. E. WOLKER  DVM  MVetSc    JAMES L. CARMALT  MA  VetMB  MVetSc  Diplomate ABVP & ACVS    DAVID G. WILSON  DVM  Diplomate ACVS 《Veterinary surgery : VS》2009,38(7):861-867

Objective— To compare the biomechanical characteristics, failure mode, and effects of side (left or right limb) and end (forelimb or hindlimb) of different screws in 2-screw, parallel-screw proximal interphalangeal joint arthrodesis constructs in horses.
Study Design— In vitro experimental study.
Sample Population— Twenty limbs from 6 cadavers (4 complete limb sets, 2 partial sets—total of 4 forelimb and 6 hindlimb pairs).
Methods— Two parallel 5.5 mm cortical (AO) screws were inserted in lag fashion in 1 randomly allocated limb of a pair, and 2 parallel headless, tapered, variable-pitched, titanium compression screws (Acutrak-Plus^®) were inserted in the contralateral limb. Constructs were tested in 3-point bending in a dorsopalmar (plantar) direction using a materials-testing machine at a loading rate of 5.83 mm/s. Maximal bending moment at failure and composite stiffness were calculated from data generated on load–displacement curves. Data were analyzed using a Friedman 2-way analysis of variance and Wilcoxon's signed-rank tests.
Results— No significant difference was detected for bending moment or stiffness values in proximal interphalangeal joint arthrodesis constructs using 2 parallel Acutrak-Plus^® or AO screws for fixation. Mean stiffness values were significantly different between forelimb and hindlimb constructs.
Conclusions— Performance of 2 parallel Acutrak-Plus^® screws was biomechanically comparable with 2 parallel AO 5.5 mm cortical screws in in vitro pastern arthrodesis constructs.
Clinical Relevance— Acutrak-Plus^® screws may provide an alternative means of fixation for proximal interphalangeal joint arthrodesis.  相似文献   

Evaluation of Efficacy and Safety of Zinc Gluconate Associated with Dimethyl Sulphoxide for Sexually Mature Canine Males Chemical Neutering     

FRM Soto  WG Viana  GCB Mucciolo  FYM Hosomi  CI Vannucchi  CP Mazzei  AR Eyherabide  C De Fátima Lúcio  RA Dias  SS De Azevedo 《Reproduction in domestic animals》2009,44(6):927-931

The aim of this research was to evaluate the efficacy of zinc gluconate associated with dimethyl sulphoxide (DMSO) for chemical neutering in canine males. Fifteen sexually mature male dogs were divided in two groups, named control and treated. An injection was administered to both testicles, at a concentration of 26.2 mg zinc gluconate per ml and 0.5% DMSO in the treated group (11 dogs). The control group was given injections of saline solution (four dogs). Clinical examination and blood collection for a haemogram were done both before and after drug injection. There were 12 spermograms performed to analyse sperm motility, sperm vigour, ejaculate volume, testicle size, pathology and sperm concentrations. Libido was also measured. An ultrasound examination and histopathology were performed at the end of the experiment. Dogs’ libido after chemical injection was reduced by over 50%. The spermogram analysis showed final mean results of 14.54% for sperm motility, 0.72 of sperm vigour and 37 150 per million spermatozoa per millilitre, values considered below the necessary levels at which fertilization can occur. Ultrasound and histopathology analyses of testicles for the treated group revealed more intense injuries when compared with the control group, with compromised testicular parenchyma and a decrease of germ cell number leading to total atrophy, indicating that the treatment reduced the fertilizing potential of male dogs, promoting a possible subfertile status.  相似文献