Hypokalaemic episodic polymyopathy in cats fed a vegetarian diet     

A. LEON  SAF BAIN  WR LEVICK 《Australian veterinary journal》1992,69(10):249-254

A previously undocumented hypokalaemic condition with a cyclical nature, comprising acute bouts of polymyopathy followed by spontaneous recoveries, is described in the cat. Cats being fed a high protein vegetarian diet developed recurrent episodes of polymyopathy, characterised by ventroflexion of the head and neck, stiff forelimb gait, lateral head-resting and generalised muscle weakness. Plasma potassium concentrations (mean +/- standard deviation) were reduced from 3.28 +/- 0.33 mmol/l at the beginning of the experiment to 2.45 +/- 0.24 mmol/l during bouts of myopathy. This hypokalaemia was associated with increased creatine kinase activities indicative of muscle damage, and decreased urinary potassium concentrations, and was caused by insufficient dietary potassium. Cats that received the same diet supplemented with potassium did not develop hypokalaemic polymyopathy. Spontaneous recoveries of affected cats were not associated consistently with increases in plasma potassium concentrations. Plasma taurine concentrations decreased and glutamic acid increased markedly in all cats fed the experimental diet. There was no evidence of thiamin deficiency associated with the high glutamic acid intake. Veterinarians should be aware that hypokalaemic cats, and in particular those on potassium-deficient diets, may show cyclical disease with episodes of polymyopathy recurring after periods of spontaneous clinical recovery. This condition in cats may be a useful animal model for familial hypokalaemic periodic paralysis in humans.  相似文献   

A seeker of the truth.     

H A Waters 《Journal of the American Veterinary Medical Association》1992,201(11):1689-1690

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Prevalence of Mycoplasma agassizii and Chelonian herpesvirus in captive tortoises (Testudo sp.) in the United Kingdom.     

Jorge F Soares  Victoria J Chalker  Kerstin Erles  Sonya Holtby  Michael Waters  Stuart McArthur 《Journal of zoo and wildlife medicine》2004,35(1):25-33

During the months of April to August in 1999 and 2002, oral swabs were collected from 146 tortoises (Testudo sp.) in private collections in the United Kingdom and tested by polymerase chain reaction (PCR) for the presence of Mycoplasma agassizii and Chelonian herpesvirus (ChHV). The presence of M. agassizii was confirmed by restriction digestion of the PCR product. A 307-bp fragment of the ChHV UL5 homologue gene was sequenced and found to show most similarity to equine herpesvirus type 1. A prevalence of 15.8 and 8.2% was found for M. agassizii and ChHV, respectively. Comparison of the carriage of both M. agassizii and ChHV in different species of tortoises correlated the presence of M. agassizii with Testudo horsfieldii and ChHV with Testudo marginata and Testudo graeca iberia. An association of ChHV with stomatitis was also found. Mixed infections with both agents were detected. The findings further demonstrate this pathogen-tortoise association and the cross transmission of these infections if different tortoise species are housed together.  相似文献   

Morphine, pethidine and buprenorphine disposition in the cat     

Taylor PM  Robertson SA  Dixon MJ  Ruprah M  Sear JW  Lascelles BD  Waters C  Bloomfield M 《Journal of veterinary pharmacology and therapeutics》2001,24(6):391-398

Pharmacokinetics of morphine, buprenorphine and pethidine were determined in 10 cats. Six cats received morphine (0.2 mg/kg) intravenously and four intramuscularly. Five received buprenorphine (0.01 mg/kg) intravenously and six intramuscularly. Six received pethidine (5 mg/kg) intramuscularly. Jugular venous blood samples were collected at time points to 24 h, and plasma morphine concentrations were measured by high performance liquid chromatograpy (HPLC), buprenorphine by radioimmunoassay (RIA) and pethidine by gas chromatography. Our data for morphine show elimination half-life (t1/2el) 76.3 min intravenous (i.v.) and 93.6 min intramuscular (i.m.); mean residence time (MRT) 105.0 and 120.5 min; clearance (Clp) 24.1 and 13.9 mL/kg/min; and volume of distribution (V(dss)) 2.6 and 1.7 L/kg, respectively. Comparable data for buprenorphine are t1/2el 416.8 and 380.2 min; MRT 417.6 and 409.8 min; Clp 16.7 and 23.7 mL/kg/min; and V(dss) 7.1 and 8.9 L/kg. For i.m. pethidine, t1/2el 216.4 min; MRT 307.5 min; Clp 20.8 mL/kg/min and V(dss) 5.2 L/kg. For i.m. dosing, the tmax for morphine, buprenorphine and pethidine were 15, 3 and 10 min, respectively. The pharmacokinetics of the three opioids in cats are broadly comparable with those of the dog, although there is a suggestion that the cat may clear morphine more slowly.  相似文献   

Upper respiratory tract disease in tortoises     

Waters M  Chalker V  Patterson-Kane J 《The Veterinary record》2003,153(10):308

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Comparison of carprofen and pethidine as postoperative analgesics in the cat     

T. V. Balmer    D. Irvine  R. S. Jones  †  M. J. Roberts  †  L. Sungsby  ‡  P. M. Taylor    A. E. Waterman  ‡ C. Waters  § 《The Journal of small animal practice》1998,39(4):158-164

The postoperative analgesia and sedation in cats given carprofen (4·0 mg/kg bodyweight by subcutaneous injection preoperatively) was compared to that in cats given pethidine (3·3 mg/kg bodyweight by intramuscular injection postoperatively) in a controlled, randomised, blinded, multicentre clinical trial. Further dosing with the particular analgesic was allowed if a cat was exhibiting unacceptable pain. In total, 57 carprofen cases and 59 pethidine cases were evaluated. Significantly fewer cats in the carprofen group required additional doses of analgesic, and mean pain scores were significantly lower from four hours after ovariohysterectomy, and at 18 to 24 hours after castration, compared to the pethidine group. In conclusion, carprofen provided as good a level of postoperative analgesia as pethidine, but of a longer duration (at least 24 hours) and was well tolerated. It thus provides an option for 'pre-emptive analgesia' in cats about to undergo surgery.  相似文献   

The Great Ocean Business: by Brenda Horsefield & Peter Bennett Stone,with a preface by Professor Sir Edward Bullard. Hodder & Stoughton,London: x + 360 pp., 27 photos plus numerous line drawings, 24 × 16 cm, £3.50, 1972     

O.D. Waters 《Biological conservation》1973,5(1):77-78

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Variances of tracheid lengths in tropical pines from central Africa     

Jeffery Burley  Philip G. Adlard  Penelope Waters 《Wood Science and Technology》1970,4(1):36-44

Summary Individual tracheid lengths were measured in macerated tissue samples of Pinus merkussii Jungh. and de Vries, P. kesiya Royle ex Gordon (syn. P. khasya Royle) and P. patula Schiede and Deppe. The sample trees were selected from stands of different ages, treatments and sites in central Africa.A sampling unit of 50 tracheids, measured for convenience on two microscope slides, was chosen on the basis of an earlier study. The variation in individual tracheid length and the variation of within-slide variance was studied by means of analysis of variance and variance components. This indicated the nunber of samples required in the different sampling categories to give maximum sampling efficiency. Sampling categories included both random factors (individual tracheids, number of slides, radii in discs) and fixed factors (annual rings, tree classes, thinning treatments, etc.).While large effects were attributable to fixed factors more than half the total variation was explained by random factors. The effect of the number of slides was rarely important and two slides need be used only to facilitate the location of the required number of tracheids and to provide a check on operator consistency. The sample unit of 50 tracheids can detect differences in tracheid length of 0.20 ... 0.34 mm thus confirming the routine used in this laboratory as a practical and meaningful procedure.Laboratory work was carried out in Kitwe, computing at Oxford. Paper published with permission of Professor of Forest Science, Oxford and Director, Agricultural Research Council of Zambia.  相似文献   

Sulfate--a candidate for the missing essential factor that is required for the formation of protein haze in white wine     

Pocock KF  Alexander GM  Hayasaka Y  Jones PR  Waters EJ 《Journal of agricultural and food chemistry》2007,55(5):1799-1807

Protein haze formation in white wine is dependent on the presence of both wine protein and other unknown wine components, termed factor(s) X. The ability to reconstitute protein haze upon heating artificial model wine solutions (500 mg/L thaumatin, 12% ethanol, 4 g/L tartaric acid) to which candidate components were added was employed to identify factor(s) X. No protein haze was formed in the absence of additives. The individual or combined addition of caffeic acid, caftaric acid, epicatechin, epigallocatechin-O-gallate, gallic acid, or ferulic acid at typical white wine concentrations did not generate protein haze. However, PVPP fining of commercial wines resulted in a reduction in protein haze, suggesting that phenolic compounds may play a modulating role in haze formation. To elucidate the nature of the unknown factor(s) wine was fractionated and fractions were back-added to model wine and tested for their essentiality. Wine fractions were generated by ultrafiltration, reverse-phase chromatography, and mixed-mode anion-exchange and reverse-phase chromatography. The only purified fraction containing the essential component(s) was free of phenolic compounds, and analysis by mass spectrometry identified sulfate anion as the dominant component. Reconstitution with KHSO4 using either commercially available thaumatin or wine proteins confirmed the role of sulfate in wine protein haze formation. The two main wine proteins, thaumatin-like protein and chitinase, differed in their haze response in model wines containing sulfate. Other common wine anions, acetate, chloride, citrate, phosphate, and tartrate, and wine cations, Fe(2+/3+) and Cu(+/2+), when added at typical white wine concentrations were not found to be essential for protein haze formation.  相似文献   

Infection with foot-and-mouth disease virus (FMDV) induces a natural killer (NK) cell response in cattle that is lacking following vaccination     

Jared R. Patch  Pervaiz A. Dar  Ryan Waters  Felix N. Toka  Jose Barrera  Christopher Schutta  Ganesh Kondabattula  William T. Golde 《Comparative immunology, microbiology and infectious diseases》2014

Natural killer (NK) cells play a role in innate antiviral immunity by directly lysing virus-infected cells and producing antiviral cytokines such as interferon gamma (IFN-γ). We developed a system for characterizing the bovine NK response to foot-and-mouth disease virus (FMDV), which causes a disease of cloven-hoofed animals and remains a threat to livestock industries throughout the world. IL-2 stimulation of PBMC resulted in poor killing of human K562 cells, which are often used as NK target cells, while lysis of the bovine BL3.1 cell line was readily detected. Depletion of NKp46-expressing cells revealed that 80% of the killing induced by IL-2 could be attributed to NKp46⁺ cells. In order to characterize the response of NK cells against FMDV in vivo, we infected groups of cattle with three different strains of the virus (A24 Cruzeiro, O1 Manisa, O Hong Kong) and evaluated the cytolytic ability of NK cells through the course of infection. We consistently observed a transient increase in cytolysis, although there was variation in magnitude and kinetics. This increase in cytolysis remained when CD3⁺ cells were removed from the preparation of lymphocytes, indicating that cytolysis was independent of MHC-T cell receptor interaction or γδ T cell activation. In contrast, animals monitored following vaccination against FMDV did not exhibit any increase in NK killing. These data suggest that NK cells play a role in the host immune response of cattle against FMDV, and contrast with the suppression of NK activity previously observed in swine infected with FMDV.  相似文献