RADIOGRAPHIC DIAGNOSIS: INTRAMEDULLARY EXTRUSION OF AN INTERVERTEBRAL DISC     

Julius M.  Liptak  BVSc  MvetClinstud  MACVSc  Graeme S.  Allan  MVSc  FACVSc  Mark B.  Krockenberger  BSc  BVSc  Phillip E.  Davis  MVSc  Richard  Malik  BVSc  MvetClinStud  PhD  FACVSc 《Veterinary radiology & ultrasound》2002,43(3):272-274

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Vaccine production of the Riems Island Friedrich Loeffler Institute     

S Tesmer  P Werner  M Glaner  B Lange  F Gentner 《Archiv fuer experimentelle veterinaermedizin》1985,39(5):684-691

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THE NON-CARDIAC DISTRIBUTION OF ^99mTC-METHOXY-ISOBUTYL-ISONITRILE (SESTAMIBI) IN NORMAL BEAGLES     

Phillip F.  Steyn  BVSc  MRCVS  MS  Gregory  Ogilvie  DVM 《Veterinary radiology & ultrasound》1995,36(2):160-163

Technetium-99m methoxy-isobutyl-isonitrile (sestamibi) is a radiophartnaceutical used for the evaluation of myocardial perfusion. Increased uptake of sestamibi has also been documented in tumors. The objective of this study was to document the extracardiac biodistribution of ^99mTc sestamibi in the normal dog. Nine normal beagles were given 0.35 mCi/kg ^99mTc sestamibi intravenously, and 60 second images were made of the entire body at 1 hour post injection. A defined distribution pattern was recognized, with good visualization of the heart, liver, gallbladder, small intestine, kidneys, urinary bladder, popliteal lymph nodes, parotid salivary glands and zygomatic salivary glands. Splenic uptake was not seen.
Target to background ratios were calculated for all the regions listed, using background regions-of-interest with the smallest coefficient of variance for the denominator. The mean, range and standard deviation of these ratios are given.  相似文献   

Extracellular heat shock protein 70 levels in tumour-bearing dogs and cats treated with radiation therapy and hyperthermia     

K. J. Nytko  M. S. Weyland  S. Dressel-Böhm  S. Scheidegger  L. Salvermoser  C. Werner  S. Stangl  A. C. Carpinteiro  B. Alkotub  G. Multhoff  S. Bodis  C. Rohrer Bley 《Veterinary and comparative oncology》2023,21(4):605-615

Hyperthermia is a form of a cancer treatment which is frequently applied in combination with radiotherapy (RT) to improve therapy responses and radiosensitivity. The mode of action of hyperthermia is multifactorial; the one hand by altering the amount of the blood circulation in the treated tissue, on the other hand by modulating molecular pathways involved in cell survival processes and immunogenic interactions. One of the most dominant proteins induced by hyperthermia is the major stress-inducible heat shock protein 70 (Hsp70). Hsp70 can be found in the blood either as a free-protein (free HSP70) derived from necrotic cells, or lipid-bound (liposomal Hsp70) when it is actively released in extracellular vesicles (EVs) by living cells. The aim of the study was to evaluate the levels of free and liposomal Hsp70 before and after treatment with RT alone or hyperthermia combined with radiotherapy (HTRT) in dogs and cats to evaluate therapy responses. Peripheral blood was collected from feline and canine patients before and at 2, 4, 6 and 24 h after treatment with RT or HTRT. Hsp70 enzyme-linked immunosorbent assays (ELISAs) were performed to determine the free and liposomal Hsp70 concentrations in the serum. The levels were analysed after the first fraction of radiation to study immediate effects and after all applied fractions to study cumulative effects. The levels of free and liposomal Hsp70 levels in the circulation were not affected by the first singular treatment and cumulative effects of RT in cats however, after finalizing all treatment cycles with HTRT free and liposomal Hsp70 levels significantly increased. In dogs, HTRT, but not treatment with RT alone, significantly affected liposomal Hsp70 levels during the first fraction. Free Hsp70 levels were significantly increased after RT, but not HTRT, during the first fraction in dogs. In dogs, on the other hand, RT alone resulted in a significant increase in liposomal Hsp70, but HTRT did not significantly affect the liposomal Hsp70 when cumulative effects were analysed. Free Hsp70 was significantly induced in dogs after both, RT and HTRT when cumulative effects were analysed. RT and HTRT treatments differentially affect the levels of free and liposomal Hsp70 in dogs and cats. Both forms of Hsp70 could potentially be further investigated as potential liquid biopsy markers to study responses to RT and HTRT treatment in companion animals.  相似文献   

Double-blinded placebo-controlled clinical trial of prophylactic omeprazole in dogs treated surgically for acute thoracolumbar intervertebral disc extrusion     

Jaya M. Mehra  M. Katherine Tolbert  Phillip Guadiano  Jörg M. Steiner  George E. Moore  Melissa J. Lewis 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(2):586-597

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Agricultural practice changes with cultivating genetically modified herbicide-tolerant oilseed rape     

F. Graef  U. Stachow  A. Werner  G. Schütte 《Agricultural Systems》2007

To facilitate weed suppression, oilseed rape or canola (Brassica napus) has been genetically modified (GM) over the last two decades to incorporate herbicide tolerance (HT). The introduction of oilseed rape in commercial agriculture raises concerns about potential adverse agronomic and environmental effects linked to both the genetic modification and altered agricultural practice. How will this new crop modify the existing cropping practice? What are the potential agro-environmental implications of its introduction? This paper analyses and schematises recorded and conceivable agricultural practice changes with GMHT oilseed rape introduction and its likely agro-environmental effects. It develops a conceptual systematics of influencing factors, subsequent practice changes and likely agro-environmental effects. The results can be used to design the mandatory monitoring of adverse GM crop effects.  相似文献   

Use of Diet Crossover to Determine the Effects of β‐glucan Supplementation on Immunity and Growth of Nile Tilapia,Oreochromis niloticus     

Thomas L. Welker  Chhorn Lim  Mediha Yildirim‐Aksoy  Phillip H. Klesius 《Journal of the World Aquaculture Society》2012,43(3):335-348

Juvenile Nile tilapia were fed either a basal (control) diet (n = 6 aquaria) or a diet supplemented with 1 g/kg β‐glucan (n = 24 aquaria) for 4 wk. At the end of this period, fish receiving β‐glucan were continued on the same diet (n = 12 aquaria) or switched to the control diet (n = 12 aquaria) for 2 wk. After 6 wk, tilapia continuously fed the β‐glucan supplemented diets had improved weight gain and feed efficiency than those fed the control diet uninterrupted or switched from the β‐glucan diet to the control after 4 wk. Feeding tilapia β‐glucan for 4 wk and then switching to the basal diet for 2 wk caused a significant increase in the respiratory burst of polymorphonuclear lymphocytes (17.77 × 10³ units/1000 white blood cells [WBC]) compared to catfish fed the control diet (13.50 × 10³ units/1000 WBC) or the β‐glucan diet continuously (13.57 × 10³ units/1000 WBC), but other immune parameters were unaffected. Tilapia were then challenged with Streptococcus iniae. The two groups were divided again (n = 6 aquaria) postchallenge and continued on the same diet or switched to the other diet (β‐glucan or control) for another 3 wk. No differences in survival to S. iniae infection occurred between dietary groups.  相似文献   

Klee- und Kleegras-Ertrags- und -Vorfruchtprüfungen im Erzgebirge Teil II: Aussaatzeiten,Bestandsentwicklung     

W. Simon  D. Eich  K. Werner 《Archives of Agronomy and Soil Science》2013,59(5):382-398

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Industrieberichte     

Peter Fritsch  Werner Knaus  Gerhard Merkl  Erwin Preininger  Joachim Rautenberg  et al. 《Anzeiger für Sch?dlingskunde》1991,64(2):40

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Titres of precocene ii (6, 7-dimethoxy-2, 2- dimethylchromene) and its metabolites in the haemolymph of larvae of the african armyworm Spodoptera exempta (walker) following topical treatment with the compound     

Alan R. McCaffery  Phillip G. McDowell 《Pest management science》1987,19(3):185-196

No precocious metamorphosis or other morphogenetic effects were seen following topical treatment of fifth instar Spodoptera exempta with pre- cocene II. [3H]-Precocene II penetrated the larvae rapidly following topical application. An uptake of 47% was recorded in the first hour and an average of 27% for the first 3 h. Radioactivity in the haemolymph reached a maximum 4 h after treatment at 6–8% of the applied dose. A maximum titre of precocene of 1.1 × 10^?4 _M was observed 2 h after treatment and a biological half-life of around 1 h was recorded for the first 6 h. The metabolite precocene 11–3, 4-dihydrodiol appeared in the haemolymph with a maximum titre of 1.1 × 10^?4 _M at 4 h suggesting metabolism via the 3, 4-epoxide. At the same time an unidentified metabolite was observed possibly corresponding to the 6- and 7-(O)-desmethylated products described by others. Very large quantities of highly polar materials were observed in the haemolymph throughout the experiment and it is thought that these corresponded to conjugates. The evidence suggests that peripheral detoxication mechanisms do not operate sufficiently rapidly to prevent the establishment of a high titre of precocene. This, however, did not affect the corpora allata in this insect, whereas in a sensitive species that has been studied by other workers, necrosis of the glands would have resulted. Alternative explanations for insensitivity are discussed.  相似文献