THE EFFECT OF FLUORINE IN NATURAL WATERS ON THE TEETH OF SMALL FISH     

Neff A 《Science (New York, N.Y.)》1935,82(2126):301-302

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Corrigendum     

R. B. Laughlin  Jr.  H. W. Wofford  J. M. Neff 《Aquaculture (Amsterdam, Netherlands)》1980,20(4):385-386

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A 115-kD polypeptide immunologically related to erythrocyte band 3 is present in Golgi membranes   总被引：5，自引：0，他引：5  

S Kellokumpu  L Neff  S J?ms?-Kellokumpu  R Kopito  R Baron 《Science (New York, N.Y.)》1988,242(4883):1308-1311

Band 3 multigene family consists of several distinct but structurally related polypeptides which are probably involved in the transport of anions across the plasma membrane of both erythrocytes and nonerythroid cells. A novel member of this family of polypeptides that resides in the Golgi complex was identified with antibodies to Band 3. The Golgi antigen had a larger molecular size and was antigenically distinct from Band 3 in the amino-terminal domain. It was expressed most prominently in cells that secrete large amounts of sulfated proteins and proteoglycans. This polypeptide may participate in sulfate transport across Golgi membranes.  相似文献   

Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic Stilbenoids     

Sobolev VS  Khan SI  Tabanca N  Wedge DE  Manly SP  Cutler SJ  Coy MR  Becnel JJ  Neff SA  Gloer JB 《Journal of agricultural and food chemistry》2011,59(5):1673-1682

The peanut plant (Arachis hypogaea L.), when infected by a microbial pathogen, is capable of producing stilbene-derived compounds that are considered antifungal phytoalexins. In addition, the potential health benefits of other stilbenoids from peanuts, including resveratrol and pterostilbene, have been acknowledged by several investigators. Despite considerable progress in peanut research, relatively little is known about the biological activity of the stilbenoid phytoalexins. This study investigated the activities of some of these compounds in a broad spectrum of biological assays. Since peanut stilbenoids appear to play roles in plant defense mechanisms, they were evaluated for their effects on economically important plant pathogenic fungi of the genera Colletotrichum, Botrytis, Fusarium, and Phomopsis. We further investigated these peanut phytoalexins, together with some related natural and synthetic stilbenoids (a total of 24 compounds) in a panel of bioassays to determine their anti-inflammatory, cytotoxic, and antioxidant activities in mammalian cells. Several of these compounds were also evaluated as mammalian opioid receptor competitive antagonists. Assays for adult mosquito and larvae toxicity were also performed. The results of these studies reveal that peanut stilbenoids, as well as related natural and synthetic stilbene derivatives, display a diverse range of biological activities.  相似文献   

A comparative study of the pharmacokinetics of quinidine     

C A Neff  L E Davis  J D Baggot 《American journal of veterinary research》1972,33(7):1521-1525

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The global impact of scaling up HIV/AIDS prevention programs in low- and middle-income countries     

Stover J  Bertozzi S  Gutierrez JP  Walker N  Stanecki KA  Greener R  Gouws E  Hankins C  Garnett GP  Salomon JA  Boerma JT  De Lay P  Ghys PD 《Science (New York, N.Y.)》2006,311(5766):1474-1476

A strong, global commitment to expanded prevention programs targeted at sexual transmission and transmission among injecting drug users, started now, could avert 28 million new HIV infections between 2005 and 2015. This figure is more than half of the new infections that might otherwise occur during that period in 125 low- and middle-income countries. Although preventing these new infections would require investing about U.S.$122 billion over this period, it would reduce future needs for treatment and care. Our analysis suggests that it will cost about U.S.$3900 to prevent each new infection, but that this will produce a savings of U.S.$4700 in forgone treatment and care costs. Thus, greater spending on prevention now would not only prevent more than half the new infections that would occur from 2005 to 2015 but would actually produce a net financial saving as future costs for treatment and care are averted.  相似文献   

The impact of boreal forest fire on climate warming   总被引：1，自引：0，他引：1  

Randerson JT  Liu H  Flanner MG  Chambers SD  Jin Y  Hess PG  Pfister G  Mack MC  Treseder KK  Welp LR  Chapin FS  Harden JW  Goulden ML  Lyons E  Neff JC  Schuur EA  Zender CS 《Science (New York, N.Y.)》2006,314(5802):1130-1132

We report measurements and analysis of a boreal forest fire, integrating the effects of greenhouse gases, aerosols, black carbon deposition on snow and sea ice, and postfire changes in surface albedo. The net effect of all agents was to increase radiative forcing during the first year (34 +/- 31 Watts per square meter of burned area), but to decrease radiative forcing when averaged over an 80-year fire cycle (-2.3 +/- 2.2 Watts per square meter) because multidecadal increases in surface albedo had a larger impact than fire-emitted greenhouse gases. This result implies that future increases in boreal fire may not accelerate climate warming.  相似文献   

Does adding microbial mechanisms of decomposition improve soil organic matter models? A comparison of four models using data from a pulsed rewetting experiment     

Corey R. Lawrence  Jason C. Neff  Joshua P. Schimel 《Soil biology & biochemistry》2009,41(9):1923-1934

Contemporary soil organic matter (SOM) models have been successful at simulating decomposition across a range of spatial and temporal scales using first-order kinetics to represent the decomposition process; however, recent work suggests the simplicity of the first-order representation of decomposition is not adequate to capture the microbially-driven dynamics of SOM decomposition over short timescales. For example, the response of soils to drying-rewetting events may best be explained by microbial and/or exoenzyme controls on decomposition. To test if adding these microbial mechanisms improves the ability of SOM models to simulate the response of soils to short-term environmental changes, we developed four different SOM decomposition models with varying mechanistic complexity and compared their ability to simulate soil respiration from a pulsed drying-rewetting laboratory-based experiment. Specifically, we tested the ability of the models to capture the timing and magnitude of soil CO₂ efflux in response to rewetting or constant moisture conditions. The results of the comparison suggest that the inclusion of exoenzyme and microbial controls on decomposition can improve the ability to simulate pulsed rewetting dynamics; however, less mechanistic first-order models prevail under steady-state moisture conditions. These modeling results may have implications for understanding the long-term response of soil carbon stocks in response to local and regional climate change.  相似文献   

Microbiological method for assaying lincomycin in animal feed: collaborative study.     

A W Neff  R W Thomas 《Journal of the Association of Official Analytical Chemists》1978,61(5):1107-1112

A microbiological assay for determining lincomycin in swine feed, supplement, and a vitamin-mineral premix was studied collaboratively in 16 laboratories. The design of the study involved a complete feed, feed supplement, and a vitamin-mineral premix covering a range of fortification from 20 to 80 g/ton and 80 to 2600 g/ton. Two methods of sample preparation were used depending on the concentration of lincomycin in the sample. Statistical evaluation of the results from the 2 methods indicated that 10 and 11 collaborators, respectively, had mean recoveries which were not significantly different from one another. Ten laboratories obtained a mean recovery of 112.2% (range 102.3--123.5%) for the lower level, and 11 laboratories obtained a mean recovery of 104.4% (range 100.0--107.7%) for the higher level. The method has been adopted as official first action.  相似文献   

Competitive effects between rainbow trout and Atlantic salmon in natural and artificial streams          下载免费PDF全文

Aimee Lee S. Houde  Andrew D. Smith  Chris C. Wilson  Pedro R. Peres‐Neto  Bryan D. Neff 《Ecology of Freshwater Fish》2016,25(2):248-260

Competition with non‐native species may impede the restoration of native species, but differences in competitive abilities among intraspecific native populations may make some populations more suitable for reintroduction than others. Here, juvenile Atlantic salmon (Salmo salar) from two allopatric populations (LaHave and Sebago) being used for reintroduction into Lake Ontario were placed into two natural stream sites differing in the presence of ecologically similar rainbow trout (Oncorhynchus mykiss). We assessed the effects of competition in the natural streams on fitness‐related traits and habitat use of the Atlantic salmon. We then compared these effects to those observed in artificial streams from a previous study. Atlantic salmon in natural streams had reduced fitness‐related traits that were associated with suboptimal microhabitats in the presence of rainbow trout, but utilised optimal microhabitats in their absence. In the presence of rainbow trout, the two Atlantic salmon populations exhibited comparable recapture proportions to each other, but the individuals from the Sebago population had better performance (body size and condition) than those from the LaHave population. Responses of both Atlantic salmon populations to competition with rainbow trout were generally similar in both direction and magnitude when compared to results from the artificial stream study. The combined results suggest that native species restoration efforts should be focused on candidate populations that are ecologically suitable to reintroduction environments, as well as on suitable habitats that do not contain exotic competitors. Moreover, this study highlights the value of controlled experiments in artificial environments for predicting fitness‐related performance in natural environments.  相似文献