Multiple-center study of reduced-concentration triamcinolone topical solution for the treatment of dogs with known or suspected allergic pruritus     

Deboer DJ  Schafer JH  Salsbury CS  Blum JR  Beale KM  Vitale CB  Muse R  Moriello KA  Garfield RA  Keefe TJ  McArthur TR 《American journal of veterinary research》2002,63(3):408-413

OBJECTIVE: To determine the efficacy of triamcinolone acetonide topical solution (TTS) in dogs for use in reduction of clinical signs of pruritic inflammatory skin diseases of a known or suspected allergic basis and to evaluate adverse effects associated with TTS administration. ANIMALS: 103 pruritic adult dogs with known or suspected allergic skin disease. PROCEDURE: Dogs were treated for 4 weeks with TTS or with vehicle solution (control dogs) in a multiple-center study. Clinical signs were scored by owners and by examining veterinarians before and after treatment. Blood samples obtained before and after treatment were subjected to routine hematologic and serum biochemical analyses. RESULTS: Treatment success, as defined by an improvement of at least 2 of 6 grades in overall clinical score, was evident in 35 of 52 (67%) TTS-treated dogs (mean improvement, 1.98) and 12 of 51 (24%) control dogs (mean improvement, 0.29). For several criteria, TTS was significantly more effective than vehicle in reducing clinical signs. Minor alterations in hematologic determinations in TTS-treated dogs were limited to slightly lower total leukocyte, lymphocyte, and eosinophil counts after treatment. Minor adverse effects were reported by owners in 6 of 52 (12%) TTS-treated and 9 of 51 (18%) control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Triamcinolone used as a spray solution at a concentration approximately one-sixth the concentration of triamcinolone topical preparations currently available for veterinary use is effective for short-term alleviation of allergic pruritus in dogs. Adverse effects are few and mild and, thus, do not preclude prolonged treatment with the solution.  相似文献   

Serologic and molecular characterization of tickborne pathogens in lions (Panthera leo) from the Fasano Safari Park, Italy.     

Alessandra Torina  Victoria Naranjo  Maria Grazia Pennisi  Tatiana Patania  Fabrizio Vitale  Pietro Laricchiuta  Angelina Alongi  Salvatore Scimeca  Katherine M Kocan  José de la Fuente 《Journal of zoo and wildlife medicine》2007,38(4):591-593

Lions (Panthera leo) are an endangered species threatened by illegal hunting, habitat loss, and infectious diseases. Little is known about the tick-borne pathogens that infect lions and could contribute to population declines. The objective of this study was to characterize Rickettsia spp., Anaplasma phagocytophilum, and Coxiella burnetii infections in 10 lions from the Fasano Safari Park in Italy by serology, polymerase chain reaction, and sequence analysis. Although animals did not show clinical signs of tick-borne diseases, evidence of infection with C. burnetii, spotted fever group Rickettsia sp., and A. phagocytophilum were found in 50%, 20%, and 10% of the lions, respectively. One of the lions tested positive for all three pathogens. This study is the first report of molecular evidence of infection with C. burnetii, Rickettsia sp., and A. phagocytophilum in lions and provides evidence that these felids become infected and serve as hosts for tick-transmitted bacteria.  相似文献   

Enhanced resistance to Phoma tracheiphila and Botrytis cinerea in transgenic lemon plants expressing a Trichoderma harzianum chitinase gene   总被引：4，自引：0，他引：4  

A. Gentile    Z. Deng    S. La Malfa    G. Distefano    F. Domina    A. Vitale    G. Polizzi    M. Lorito    E. Tribulato 《Plant Breeding》2007,126(2):146-151

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Influence of Phytohemagglutinin on the Agronomic Performance of Beans (Phaseolus vulgaris L.)     

M. Confalonieri    R. Bollini    N. Berardo    A. Vitale  A. Allavena 《Plant Breeding》1992,109(4):329-334

The abundant lectin phytohemagglutinin (10 % of total seed protein) does not contain sulfur amino acids and, being a potent antimetabolite, it is responsible for the lowering of the nutritional value of bean seeds. The aim of the present work was to improve the dry bean cultivar ‘Taylor's Horticultural’ (Asgrow), by genetically introducing the lectin null (lec/lec) character from two null genotypes: ‘Pinto UI 111’ and ‘Heidi’. Thirty-seven BC²F₃ and fourteen BC₆F₅ inbred lines were evaluated in agronomical trials. Analysis of Variance (ANOVA) showed significant differences among BC₂F₃ breedings lines for all traits under evaluation. Comparison of the LedLee genotypes versus lec/lec did not show statistically significant differences in the means for the following traits: yield, yield components and percentage of protein in the seed. Fourteen BC6F5 lines, compared together with their recurrent parent ‘Taylor's Horticultural’, showed significant differences among genotypes for 1000 seed weight, protein percentage on dry matter and ash percentage. No significant differences were observed for grain yield. The data indicate that lectin removal did not have a detrimental effect on the traits evaluated.  相似文献   

Heterogeneous three-dimensional electronics by use of printed semiconductor nanomaterials     

Ahn JH  Kim HS  Lee KJ  Jeon S  Kang SJ  Sun Y  Nuzzo RG  Rogers JA 《Science (New York, N.Y.)》2006,314(5806):1754-1757

We developed a simple approach to combine broad classes of dissimilar materials into heterogeneously integrated electronic systems with two- or three-dimensional layouts. The process begins with the synthesis of different semiconductor nanomaterials, such as single-walled carbon nanotubes and single-crystal micro- and nanoscale wires and ribbons of gallium nitride, silicon, and gallium arsenide on separate substrates. Repeated application of an additive, transfer printing process that uses soft stamps with these substrates as donors, followed by device and interconnect formation, yields high-performance heterogeneously integrated electronics that incorporate any combination of semiconductor nanomaterials on rigid or flexible device substrates. This versatile methodology can produce a wide range of unusual electronic systems that would be impossible to achieve with other techniques.  相似文献   

The effects of restriction of movement on the reliability of heart rate variability measurements in the horse (Equus caballus)     

Valentina Vitale  Rita Balocchi  Maurizio Varanini  Micaela Sgorbini  Alberto Macerata  Claudio Sighieri  Paolo Baragli 《Journal of Veterinary Behavior: Clinical Applications and Research》2013,8(5):400-403

Analysis of heart rate variability (HRV) is a noninvasive approach for investigating the sympathovagal balance of the autonomic nervous system. In recent years, HRV has been increasingly evaluated in animal research. In horses, it has been suggested that basal resting conditions can be achieved by restraining them. The aim of this study was to verify how restriction of movement influences HRV i2n horses. Ten healthy standardbred mares were used to measure the electrocardiographic signal under 2 conditions: free to move in the stall and restrained in the stock. Results indicate that the restriction of movement is associated with increased nervous system sympathetic activity not consistent with resting conditions.  相似文献   

Composition and Quantitation of Microalgal Lipids by ERETIC 1H NMR Method     

Genoveffa Nuzzo  Carmela Gallo  Giuliana d’Ippolito  Adele Cutignano  Angela Sardo  Angelo Fontana 《Marine drugs》2013,11(10):3742-3753

Accurate characterization of biomass constituents is a crucial aspect of research in the biotechnological application of natural products. Here we report an efficient, fast and reproducible method for the identification and quantitation of fatty acids and complex lipids (triacylglycerols, glycolipids, phospholipids) in microalgae under investigation for the development of functional health products (probiotics, food ingredients, drugs, etc.) or third generation biofuels. The procedure consists of extraction of the biological matrix by modified Folch method and direct analysis of the resulting material by proton nuclear magnetic resonance (¹H NMR). The protocol uses a reference electronic signal as external standard (ERETIC method) and allows assessment of total lipid content, saturation degree and class distribution in both high throughput screening of algal collection and metabolic analysis during genetic or culturing studies. As proof of concept, the methodology was applied to the analysis of three microalgal species (Thalassiosira weissflogii, Cyclotella cryptica and Nannochloropsis salina) which drastically differ for the qualitative and quantitative composition of their fatty acid-based lipids.  相似文献   

Increasing incomes of Malian cotton farmers: Is elimination of US subsidies the only solution?     

Felix G. Baquedano  John H. Sanders  Jeffrey Vitale 《Agricultural Systems》2010,103(7):418-432

In a WTO battle and the press the argument is often made that eliminating US cotton subsidies would have a large effect on the incomes and competitive position of farmers in developing countries. In Francophone West Africa cotton productivity has stagnated after rapid gains in the first two decades following independence (1960-1980). A farm model was constructed based on farmers’ definition of their decision-making framework which they use to respond to income and weather risks. With this model the effects on farmers of eliminating US subsidies are compared with various productivity increasing measures for cotton and sorghum in Dioila, Mali. Dioila is located in a representative cotton region producing 16% of the cotton in Mali. We include sorghum due to its importance for consumption and the observation of Malian farmers substituting cereals (sorghum and maize) for cotton as the returns to cotton have fallen in the 21st Century. In the farm model, the elasticity of transmission of a change in the world cotton price to the farm gate price is taken into account. The gains from eliminating US subsides are small. In contrast, the various technological alternatives including Bt cotton introduction, the use of higher fertilization levels for cotton, and the introduction of improved sorghum cultivars and moderate fertilization along with a marketing package all have substantially higher returns Even with substantial improvement in the mechanisms enabling farmers to benefit from the higher prices resulting from elimination of US subsidies, there are still much higher returns resulting from the various types of productivity increases.  相似文献   

In situ photo-polymerization of soil organic matter by heterogeneous nano-TiO2 and biomimetic metal-porphyrin catalysts     

Assunta Nuzzo  Elisa Madonna  Pierluigi Mazzei  Riccardo Spaccini  Alessandro Piccolo 《Biology and Fertility of Soils》2016,52(4):585-593

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Postharvest efficacy of resistance inducers for the control of green mold on important Sicilian citrus varieties     

Panebianco  Salvina  Vitale  Alessandro  Platania  Claudia  Restuccia  Cristina  Polizzi  Giancarlo  Cirvilleri  Gabriella 《植物病害和植物保护杂志》2014,121(4):177-183

Journal of Plant Diseases and Protection - The disease reducing activity of acibenzolar-S-methyl (ASM), chitosan and β-aminobutyric acid (BABA) against postharvest green mold (GM) of citrus...  相似文献