排序方式： 共有2条查询结果，搜索用时 46 毫秒
1
1.
Kimchi-Sarfaty C Oh JM Kim IW Sauna ZE Calcagno AM Ambudkar SV Gottesman MM 《Science (New York, N.Y.)》2007,315(5811):525-528
Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur. We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions. Similar mRNA and protein levels, but altered conformations, were found for wild-type and polymorphic P-gp. We hypothesize that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites. 相似文献
2.
The effect of Neem on the development ofEarias insulana Boisd. was investigated. Different concentrations of an aqueous extract of Neem kernels were incorporated in a semi-synthetic diet and larval growth, pupation rate and mortality of larvae were recorded. Neem was highly effective against 7-8- and 12-day-old larvae at all concentrations ranging between 0.075 and 1%. The systemic activity of Neem was investigated by standing cotyledons of a glandless cotton strain with their petioles in different concentrations of Neem. After 72 hours feeding at all concentrations tested, larval weight was about half that on the untreated leaves. 相似文献
1