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Single trait selection was practiced in three lines of Hereford cattle at two locations. Bulls were selected within sire families for increased weaning weight (WW) in the WW line (WWL), for postweaning gain (PG) in the PG line (PGL) and at random in the control line (CTL). Data include the performance of 2,467 calves produced from 1967 to 1981. Environmental effects were estimated from CTL (method I) and from multiple regression procedures (method II). Phenotypic and environmental time trends were negative for WW and generally were positive for PG. Estimated genetic gains for WW in WWL were 1.07 +/- .51 kg/yr in bulls and .62 +/- .36 kg/yr in heifers using method I and .50 +/- .31 kg/yr in bulls and .10 +/- .17 kg/yr in heifers using method II. Corresponding values for PG in PGL were .85 +/- .40 and 1.03 +/- .24 kg/yr in bulls and .30 +/- .28 and .37 +/- .12 kg in heifers. Correlated genetic gains for WW in PGL were larger than direct WW gains, whereas genetic gains for PG in WWL were smaller than direct PG gains. From method I, estimates of realized heritability (h2R) for WW were .31 +/- .18 in bulls and .22 +/- .13 in heifers. For PG, h2R was .31 +/- .13 in bulls and .06 +/- .12 in heifers. Using method II, h2R for WW was .09 +/- .08 in bulls and .02 +/- .07 in heifers. Corresponding values for PG were .29 +/- .10 and .11 +/- .08. Joint estimates of the realized genetic correlation between WW and PG were .69 +/- .18 and .46 +/- .31 for methods I and II, respectively. Variation in selection response was evaluated using quasi-replicates. Results of this study indicate that selection for PG improved both WW and PG faster than selection for WW.  相似文献   
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AIMS: To report on the long-term outcomes of hydraulic artificial urethral sphincter (HAUS) placement for the correction of urethral sphincter mechanism incompetence (USMI) in New Zealand dogs.

METHODS: Retrospective data were obtained from cases of dogs which had a HAUS placed after failed medical and/or surgical management of USMI between August 2012 and November 2016. Owner assessment of urinary incontinence was evaluated by an online survey in May 2017 using a visual analogue scale (0 being normal, 100 being severely affected) for the frequency, volume and severity of any straining to urinate, immediately prior to the placement of the HAUS and at the time of the survey. The number of days between surgery and the completion of survey were recorded.

RESULTS: Seven females and two male dogs, which were all desexed except for one female, were eligible for inclusion in the study. The period of follow-up following HAUS placement ranged from 206–1,685 days. Following HAUS placement, frequency and volume of urinary incontinence decreased for six dogs and were practically unchanged for three dogs. The median frequency score decreased from 70 to 13 and the volume score decreased from 73 to 12. There was no consistent change in the perceived degree of straining to urinate. Complications occurred in three dogs; one required repositioning of a dislodged injection port, one required management for haematuria and a hypoplastic bladder, and one required surgical removal of fibrous tissue around the HAUS cuff.

CONCLUSIONS AND CLINICAL RELEVENCE: HAUS placement was an effective method for the treatment of persistent USMI in most dogs and provided good clinical results based on owner assessment. The technique was associated with few complications and allowed successful long-term control of urinary incontinence without the need for medical management.  相似文献   

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"人、机、料、法、环"与兽药GMP的关系   总被引:1,自引:0,他引:1  
本文尝试将质量管理学中五要素"人、机、料、法、环"的重要概念引入到兽药GMP管理体系中来,便于记忆和理解,有助于进一步认识、掌握和运行GMP.  相似文献   
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当前兽药地方标准清理工作已进入攻关阶段,但在清理地方标准的实际工作中尚存在一些问题,笔者分析了这些具体问题,认为在升标工作中,政府应当给予合理的政策扶持,加快地方标准清理工作进度,保护企业利益;企业应当着重做好品种筛选,合理安排临床试验资金投入;企业通过采取联合参与升标方式,减少资金投入;对于移植外省标准,可采取不同措施妥善解决;为保证升标工作顺利进行,农业部和各省兽医行政管理部门应做好升标培训指导工作.  相似文献   
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Most processing snap bean fields are treated with fungicides at flowering to suppress white mould, one of the more significant diseases of this crop. Farmers would like to know when their fields are at sufficient risk of white mould, to plan fungicide applications or avoid spraying if the risk is below a tolerable threshold. In 2006, 2007 and 2008, observational data were collected from processing snap bean fields across western and central New York State, USA. White mould was found in 20% of fields. Boosted regression trees were used to model white mould presence or absence in a field (a binary response variable) as a function of agronomic and edaphic variables, and macroscale drought indices. The five most important predictors were canopy openness during pod development, the number of days after planting, hydrologic soil group, canopy openness during bloom and elevation. The risk of white mould increased by about 20% when canopy openness was less than 20 cm at the bloom stage and c. 30% when canopy openness was less than 30 cm at the pod stage. The most relevant interaction was between canopy openness at the pod stage and hydrologic soil group. A random forest model for predicting the presence of white mould by bloom had an estimated classification accuracy of 73%. The extension of these results to remote forecasting of white mould in processing snap bean production is discussed.  相似文献   
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当前兽药生产企业已全面通过GMP验收,兽药科技创新成为后GMP时代企业生存发展的首要任务。在此形势下江苏省提出了“建设兽药强省”工作思路。针对当前江苏乃至全国兽药产业现状进行了调查分析和研究探索,就如何充分利用本省科研优势和GMP建设形成的基础设施优势,在政府投入引导机制、合作创新开发机制和企业内研发机制等方面提出了建设性意见。  相似文献   
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