Evaluation of sedative,analgesic, physiological,and laboratory effects of two doses off medetomidine and xylazine in dromedary calves     

Amir Saeed Samimi  Ehsanollah Sakhaee  Fattah Iranmanesh 《Journal of veterinary pharmacology and therapeutics》2019,42(4):411-419

The present study aims to comparatively evaluate the effects of different doses of intravenous xylazine and medetomidine on sedation and antinociception scores, and physiological and laboratory parameters in dromedary calves. Thirty clinically healthy male dromedary calves 15 ± 2 weeks old and weighing 95 ± 5.5 kg were studied. Two groups received xylazine at low (0.2 mg/kg) and high (0.4 mg/kg) doses. Two groups received medetomidine at low (10 µg/kg) and high (20 µg/kg) doses. One group received normal saline. Sedation signs were scored using a 3‐point scale. Analgesic effect was analyzed using pinpricks. Data were analyzed by one‐way ANOVA and Mann–Whitney U‐tests. Sedation and antinociception scores of the animals 1 hr after receiving the higher dose of xylazine and medetomidine were significantly higher than that of other groups. Compared with other studied groups, the animals receiving the higher dose of xylazine showed significantly higher potassium and creatinine serum levels after 24 hr. Doses as high as 0.4 mg/kg for xylazine and 20 µg/kg for medetomidine can be considered safe and useful for procedures associated with mild pain in dromedary calves.  相似文献   

Effect of Winter Planting Date on Oil Yield and Fatty Acids of New Spring Canola (Brassica napus L.) Cultivars Under Foliar Zinc Spray     

Mozafari  Hamid  Shirani Rad  Amirhosein  Jalili  Ehsanollah  Sani  Behzad  Rajabzadeh  Faezeh 《Gesunde Pflanzen》2022,74(2):435-446

Canola (Brassica napus L.) oil yield and fatty acid composition are the function of genotype, climate conditions, morphology, and physiology as well as crop management. In this study, the reaction of different canola cultivars—in terms of seed oil content and fatty acids—to different planting dates and foliar zinc application during two experimental years (2016–2017) was investigated in the field in arid and semi-arid regions of Karaj, Iran. The experiment was performed as a factorial split plot in a randomized complete-block design with three replications. Three sowing dates (February 9, 19, 29) and two foliar zinc applications (non-application as control and zinc application; spraying in the stem elongation stage) were factorially randomized to main plots, and canola cultivars (Sarigol, Dalgan, Salsa, and Solar) were allocated to sub-plots. The results indicated that the effect of year, planting date, zinc application, cultivar, and the interaction effect of planting date and cultivar on quality traits (glucosinolate and fatty acids) and seed yield were significant (p?<?0.01). The delay in winter planting of spring canola cultivars caused a significant reduction in seed yield, oil yield, and the content of oleic, linoleic, and palmitic fatty acids and increased the content of linolenic, erucic, stearic, arachidic, and behenic fatty acids and glucosinolate. The highest seed yield (4732.2?kg/ha), oil yield (2066?kg/ha), and oleic acid content (66.52%) were observed in the Dalgan cultivar in the zinc application treatment with normal planting date (February 9). The Salsa cultivar had the highest content of erucic acid (0.46%) and glucosinolate (17.3?μmol/g meal) in the control treatment with the last planting date. Because the quality of edible canola oil depends on the increase in unsaturated fatty acids, particularly oleic and linoleic acids, and the reduction of erucic acid and glucosinolate, planting Dalgan cultivar with zinc application at the normal planting date is recommended for the study area and similar areas.

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The first serologic study of Q fever in sheep in Iran     

Sakhaee  Ehsanollah  Khalili  Mohammad 《Tropical animal health and production》2010,42(7):1561-1564

Coxiella burnetii is an obligate intracellular microorganism that causes Q fever in humans and animals. In ewes, C. burnetii infections are generally asymptomatic, but they can lead to abortions, stillbirths, and delivery of weak and unviable lambs. Serological assays are suitable for screening herds. Enzyme-linked immunosorbent assays (ELISA) technique has a high sensitivity and a good specificity. The aim of this study was to investigate the presence of anti-C. burnetii antibodies among sheep in southeast Iran. A total of 85 serum samples were collected from ten sheep flocks from April to September 2009. Serum samples were tested for Q fever antibodies using a commercial indirect ELISA kit. Antibodies were detected in 25 sera (29.42%) of 85 samples. Sixteen female (18.82%) and nine male (10.58%) cases had antibodies specific to C. burnetii. There is significant difference in seropositivity between male and female groups (P < 0.05). This first study of C. burnetii seroprevalence in sheep in southeast Iran has indicated that seropositive animals can be found throughout the country. Further work is now required to characterize the epidemiology of the infection more thoroughly.  相似文献   

Epidural ketamine in the dromedary camel     

Azari O  Molaei MM  Emadi L  Sakhaee E  Esmaeili M 《Veterinary anaesthesia and analgesia》2012,39(3):291-295

ObjectiveTo evaluate the clinical and physiological effects of epidural injection of ketamine in camels.Study designRandomized prospective study.AnimalsTen healthy immature male dromedary camels.MethodsKetamine was administered epidurally at doses of 1 and 2 mg kg^?1 (five animals in each treatment). The drug was injected into the first intercoccygeal epidural space. Anti-nociception, sedation, ataxia, and effect on cardiopulmonary, rectal temperature and some selected haematological parameters were recorded at different intervals before (baseline) and after the drug administration. Data were analyzed by anova or U Mann–Whitney tests, as relevant and significance was taken as p < 0.05.ResultsEpidural ketamine at the 2 mg kg^?1 dose produced complete anti-nociception in the tail, anus and perineum, whilst the 1 mg kg^?1 dose produced complete anti-nociception only in the tail. Epidural ketamine resulted in mild to moderate sedation at the 1 mg kg^?1 dose and deep sedation at the 2 mg kg^?1 dose. Ataxia was observed in all test subjects and was severe, resulting in recumbency, in the 2 mg kg^?1 group. Respiratory rate and rectal temperature did not change significantly after injection of either treatment. Following epidural injection of 2 mg kg^?1 of ketamine, heart rate increased significantly from the pre-injection baseline of 55 ± 2 to 76 ± 4 (mean ± SD) beats minute^?1, but after the lower dose changes were not significant. The only significant changes in measured haematologic parameters were decreases in total erythrocyte count at 45 minutes and total leukocyte count from 45–75 minutes, in the 2 mg kg^?1 group.ConclusionEpidural ketamine injection was associated with caudal anti-nociception, sedation and ataxia in the dromedary camels; the intensity and duration of which was dose dependant.Clinical relevanceNeither of the doses of epidural ketamine injection in our study was applicable for standing surgical procedures in dromedary camels.  相似文献