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排序方式: 共有2420条查询结果,搜索用时 15 毫秒
1.
Mark D. Rawling Nicola Pontefract Ana Rodiles Ilektra Anagnostara Eric Leclercq Marion Schiavone Mathieu Castex Daniel L. Merrifield 《Journal of the World Aquaculture Society》2019,50(6):1108-1122
Fish were fed a single‐strain yeast fraction (SsYF; 2 g/kg) or a multistrain yeast fraction (MsYF; 0.8 g/kg) for 10 weeks. The results demonstrated significant (p ≤ 0.03) elevations in weight gain, specific growth rate, protein efficiency ratio, and feed conversion ratio in fish fed the yeast fraction‐supplemented diets. In the distal intestine, a significant elevation in microvilli density was observed after 5 and 10 weeks of dietary supplementation with MsYF and SsYF, respectively, compared to control fed fish (p < 0.001). A significant elevation (p = 0.02) in the perimeter ratio was observed in fish fed diets supplemented with the yeast fractions. After 10 weeks of feeding on the experimental diets, Rt‐qPCR demonstrated a significant downregulation (p < 0.05) in the stress response genes, heat‐shock protein 70 (hsp70) and proliferating cell nuclear antigen (pcna), in fish fed diets supplemented with the yeast fractions. Significant (p < 0.05) elevations in interleukin 1‐beta (il1β) and interleukin‐10 (il10) gene expression were observed in fish fed diets supplemented with the MsYF compared to the other dietary groups. These findings suggest that feeding an MsYF specifically at a lower incorporation rate < 1 g/kg, compared to a commercial SsYF at 2 g/kg, is effective in improving the intestinal health status and growth performance of European seabass. 相似文献
2.
Donald E. Thrall DVM PHD Margaret C. McEntee DVM† Carol Novotney DVM† Marlene L. Hauck DVM† Rodney L. Page DVM MS† 《Veterinary radiology & ultrasound》1993,34(4):295-300
Eighteen dogs with malignant nasal cavity tumors were treated with radiation therapy, including a boost technique. Three 3:0 Gy boost doses were added to a treatment protocol consisting of sixteen 3.0 Gy daily fractions, bringing the total dose to 57 Gy. This boost technique was implemented without an associated increase in overall treatment time by giving the boost doses on a twice-a-day basis. Boost doses were given during the first half of the radiation therapy period. The treatment was completed as planned in 16 of the 18 dogs; two dogs received lower doses (51 and 54 Gy). Median survival was 177 days, poorer than in some other reported studies of nasal tumor irradiation. Acute effects were unacceptable, with 11 of the 18 dogs developing severe mucositis, desquamation, edema, swelling, and pruritus. The extensive nature of the acute reactions compromised assessment of the effect of the increased radiation dose on the tumor. Although there is justification for assessing more aggressive radiation protocols in canine nasal tumor patients, total doses approximating 60 Gy can not be given as described because of the inability of acutely responding normal tissues to compensate. 相似文献
3.
Pharmacokinetic and Phase I Evaluation of Carboplatin in Dogs 总被引:1,自引:1,他引:0
Rodney L. Page DVM MS Margaret C. McEntee DVM Steven L. George PhD Patrick L. Williams PhD Greta L. Heidner DVM Carol A. Novotney DVM Jim E. Riviere DVM PhD Mark W. Dewhirst DVM PhD Donald E. Thrall DVM PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1993,7(4):235-240
Thirty dogs with spontaneously occurring malignant neoplasms were treated monthly with carboplatin (CBDCA) given as a 30-minute intravenous infusion in a dose escalation study. Twenty-eight dogs were considered evaluable for toxicity. The maximally tolerated dose of CBDCA was conceptually defined as that dose, determined by logistic regression analyses of toxicity data, resulting in a 50% incidence of moderate toxicity (MOD50) or a 5% incidence of severe toxicity (SEV5). Each designated maximally tolerated dose was calculated for the first course of treatment only and for the first and second courses of treatment combined to estimate cumulative drug toxicity. The MOD50 and SEV5 for the first treatment course were 340 and 278 mg/M2, respectively. MOD50 and SEV5 values for the first plus second treatment courses were 327 and 231 mg/M2, respectively. The nadir of neutrophil and platelet counts occurred approximately 14 days after treatment. The mean neutrophil and platelet values for all dogs experiencing myelosuppression during the first two treatment courses were 1541/μL and 62,600/μL, respectively. Nonparametric pharmacokinetic analysis of plasma CBDCA values suggested that half-life (T1/2), area-under-the-curve and total body clearance (CLb) were not dose dependent. Volume of distribution (VDss) significantly increased with dose only between 100 and 150 mg/M2, not between 150 and 300 mg/M2. Dose-independent serum CBDCA pharmacokinetic disposition indicates that detailed investigation of tissue CBDCA distribution would be warranted and may identify novel dosing strategies that could improve the therapeutic index of CBDCA by minimizing toxicity. (Journal of Veterinary Internal Medicine 1993; 7:235–240. Copyright © 1993 by the American College of Veterinary Internal Medicine.) 相似文献
4.
Rural depopulation and recent landscape changes in a Mediterranean region: Consequences to the breeding avifauna 总被引:8,自引:0,他引:8
We studied the vegetational and avifaunistic changes following rural depopulation in an area covering 2,600 ha north of Montpellier
(Southern France). The study area is covered by a mosaic of Mediterranean habitats that includes cultivation, grasslands,
shrublands, and woodlands and is representative of the natural features present and of the human usage practiced so far in
this part of the Mediterranean.
We sampled the vegetation and the bird fauna in the same 193 census plots in 1978 and in 1992. At both the habitat and landscape
scales the cover of woody plants increased significantly. Open habitats tend to disappear. As a consequence the abundance
of open-habitat bird species decreased significantly whereas the abundance of forest birds increased significantly. These
changes favor a pool of forest species widespread in western Europe and reduce habitat availability for open habitat and shrubland
species. Many of the latter are Mediterranean species whose distribution in Western Europe could become reduced under current
landscape dynamics. Our observation of more woodlands and their typical birds and of less open habitats and their associated
avifauna is not consistent with the traditional worry shown by the public and the managers about the regression of forests
and woodlands in the Northern Mediterranean as a consequence of fire. 相似文献
5.
6.
Field studies with convalescent serum and infectious bursal disease vaccine to control turkey coryza
Convalescent serum given to 1-day-old poults delayed clinical signs of turkey coryza by several days and reduced mortality on infected farms. Turkey breeders immunized with cell-culture-adapted infectious bursal disease virus (IBDV) or turkey infectious bursal disease virus (TIBDV) had a marked increase in virus-neutralization (VN) antibody titers. The VN antibody titer was significantly higher in progeny poults than in poults from unimmunized breeders. Clinical turkey coryza and mortality was considerably less in poults from IBD- or TIBD-vaccinated breeders than in control poults. They also responded more favorably to hemorrhagic enteritis and fowl cholera vaccination. 相似文献
7.
Nicolas Rose Alain Abhervé-Guéguen Gérald Le Diguerher Eric Eveno Jean-Pierre Jolly Philippe Blanchard Aurélie Oger André Jestin François Madec 《Livestock Production Science》2005,95(3):177-186
The aim of this study was to determine the potential risk factors for PMWS at the individual pig level and assess the effect of the Pietrain paternal genetic background of the animals in a cohort study. The survey was set up in four PMWS-affected farms with 2 repetitions (batches) per farm. A representative sample of 60 pigs per batch, stratified according to the paternal genetic background (Pietrain: yes vs. no), was randomly selected after farrowing. The representative cohort was divided into 8 batches and the pigs were individually monitored from birth to slaughter. Survival analysis was used to determine the factors related to the time to PMWS. The litter-cluster effect was taken into account using the marginal Cox model (robust estimation of the covariance matrix) and the gamma shared frailty model which were compared.No protective effect of the Pietrain breed on the time to PMWS and the proportion of affected pigs in the offspring was found in this study. Piglets showing low circovirus type 2 (PCV2) titres at 7 weeks-old with no subsequent seroconversion and piglets from PCV2 negative sows were most likely to be affected by PMWS (HR=7.0 and 2.8, respectively). Active infection of the pregnant dams with parvovirus was related to an increased risk of PMWS in the offspring (HR=2.3). Neck injuries due to poorly performed injections in the dams were associated with an increased risk of PMWS with the marginal model (HR=2.1). Oxytocin injection (dams) during farrowing was protective against PMWS in the offspring (HR=0.6). 相似文献
8.
9.
Effects of land ownership and landscape-level factors on rare-species richness in natural areas of southern Ontario,Canada 总被引:5,自引:0,他引:5
Lovett-Doust J. Biernacki M. Page R. Chan M. Natgunarajah R. Timis G. 《Landscape Ecology》2003,18(6):621-633
Surprisingly few studies have considered the extent to which the nature of the ownership of land is associated with differences
in biodiversity. We analysed ownership and other landscape-level effects on rare-species richness for both globally- and regionally-rare
biota (including birds, herpetofauna, butterflies, mammals, and plants) in 289 designated natural areas (NAs) in southern
Ontario, Canada. Information about each NA −including area, number of plant communities, ownership status and details of species
diversity were collected from published sources. Length of perimeter of NA, relative isolation, and an estimate of fragmentation
were measured using image analysis and GIS techniques. NAs were in general relatively small, with mean area of 158 ha (median
85 ha, range from 0.9 to 1278 ha) for private NAs; public NAs had mean area of 132 ha (median 16 ha, range from 0.1 to 1481
ha). Mean number of plant communities was 4.6 (median 4, range 1- 13) at private NAs and 3.8 (median 3, range 1-16) at public
NAs. Our results show that, of several landscape-level factors, area had the greatest effects on rare-species richness and
other biotic indices. Effects of area were followed by effects of plant community diversity, however this was itself significantly
affected by area and the extent of perimeter of the NA. Both these factors were followed by effects of ownership of the NA
and by effects of isolation of the NA (represented by minimum distance to nearest NA and by number of NAs in 10 km radius).
Other landscape- level factors did not appear to have overall significant effects. Variation in area accounted for 0.1% to
29% of variation in number of rare species, with lower values for globally-rare, than for regionally-rare taxa. For all biotic
groups, public ownership of NAs was associated with significantly greater rare-species richness compared to private ownership,
even after other factors such as area were controlled. For all globally-rare biota except butterflies, area of NA had greater
effects on rare-species richness than did ownership. Richness of regionally- rare birds was more affected by plant community
diversity than by area of NA. Number of recorded plant communities accounted from 2.1% of variation in number of globally-rare
plant species to as high as 31% of variation in regionally-rare butterflies. The diversity of plant communities was itself
influenced by total site area (accounting for 45% of variation), extent of elongation of the NA, and both external- and interior-
edge perimeters. Public NAs had greatest numbers of rare biota and so should be a significant focus for conservation programs.
Smaller, privately-owned patches of natural area dominate (by number and area) in this densely populated region and their
significance should not be overlooked.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献