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Neurotoxicity complicates the use of several commonly administered chemotherapeutic agents (platinum based alkylating agents, taxanes and vinca alkaloids), with chemotherapy-induced peripheral neuropathy being the most common manifestation. Structural damage to the peripheral nervous system results in positive symptoms, e.g., allodynia, hyperalgesia and pain with unpleasant features as burning and shooting. Patients are unable to complete full or optimal treatment schedules. The pathophysiologic basis of nerve injury in chemotherapy-induced peripheral neuropathy is incompletely understood and appears to be unique for each class of the chemotherapeutic agents. Erythropoeitin (EPO), a well-established hematopoietic factor, is a very effective and widely used treatment for anemia in cancer patients undergoing chemotherapy. It also possesses generalized neuroprotective and neurotrophic properties. Co-treatment of chemotherapy and erythropoietin has been proposed for preventing or reversing the disabling peripheral neuropathy induced by the different chemotherapeutic agents. This study first describes the pathophysiological background of the clinically relevant chemotherapeutic agents-inducing peripheral neuropathy. Secondly, the possible mechanisms that might underlie the neuroprotective effect of erythropoietin in chemotherapy-induced neuropathy. Further clinical trials of EPO in cancer patients receiving chemotherapy and suffering from neurological symptoms seem to be warranted in the future. This might improve the quality of life in cancer patients. 相似文献
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Plectanocotyle major sp. n. (Monogenea: Polyopisthocotylea: Plectanocotylidae) is described from Chelidonichthys obscurus (Bloch et Schneider, 1801) collected from the Mediterranean coasts (Tunisia and France). The new species is compared to Plectanocotyle gurnardi collected on Chelidonichthys gurnardus and the only other valid species in the genus Plectanocotyle. The new species differs from P. gurnardi by the clamp size (137 microm vs 64 microm for clamp length and 110 microm vs 60 microm for clamp width, respectively) and the length of the male copulatory organ (107 microm vs 144 microm, respectively). Species of the Plectanocotylidae seem to be characterized by an oioxenic specificity. 相似文献
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Othmen Soukaina Ben Boussaa Faten Hajji-Hedfi Lobna Abbess Khaled Dbara Soumaya Chermiti Brahim 《European journal of plant pathology / European Foundation for Plant Pathology》2022,163(1):51-59
European Journal of Plant Pathology - Insect feeding induces physiological and biochemical changes in host plants. Indeed, symptom severity often depends on insect density. Recently, the carrot... 相似文献
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Journal of Plant Diseases and Protection - BUPM95 is a Bacillus thuringiensis subsp. kurstaki strain producing the Vip3Aa16 protoxin with an interesting insecticidal activity against the... 相似文献
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Most ecological studies in North Africa reveal a process of continuous degradation of rangeland ecosystems as a result of overgrazing. This degradation appears across the decreasing of perennial grass diversity. Indeed, the majority of steppe ecosystems are characterized by a low density of perennial grass species at present. This study evaluated the effects of temperature and water limitation on the seed germination of Stipagrostis ciliata(Desf.) de Winter, a perennial grass species. The seeds were collected from the Bou Hedma Park, Sidi Bouzid Governorate, Central Tunisia. The thermal time and hydrothermal time models were used to describe the seed germination of S. ciliata under different water potentials and temperatures. The germination response of S. ciliata seeds in darkness was evaluated over a range of temperatures(15°C, 20°C, 25°C, 30°C and 35°C) and across a wide range of osmotic potentials(0.0, –0.2, –0.6, –1.2, –1.6 and –2.0 MPa) of the polyethylene glycol(PEG6000) solutions at each temperature level. Among the tested temperatures, 25°C was found to be the optimal temperature to the germination of S. ciliata seeds. The final germination percentage(75.2%) was obtained with distilled water. The progressive decrease of osmotic potential of the PEG6000 solutions inhibited the seed germination. However, the number of days to first germination was increased with a reduction of osmotic potential. A significant positive relationship was identified between final germination percentage of S. ciliata seeds and osmotic potential of the PEG6000 solutions, with R~2 ranging from 0.5678 to 0.8761. Furthermore, a high degree of congruency between predicted and observed germination time course curves was observed. In general, S. ciliata exhibits a significant adaptation capacity for water limitation and high temperature in arid ecosystems. 相似文献
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Ghribi Dhouha Elleuch Mouna Abdelkefi-Mesrati Lobna Boukadi Hanen Ellouze-Chaabouni Semia 《植物病害和植物保护杂志》2012,119(1):24-29
Journal of Plant Diseases and Protection - The present investigation aimed to throw light on the effect of Bacillus subtilis SPB1 biosurfactant on the third larval instars of the Mediterranean... 相似文献
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Lobna Ben Mohamed Mohamed Cherif Moncef Harrabi Rex F. Galbraith Richard N. Strange 《European journal of plant pathology / European Foundation for Plant Pathology》2010,126(3):293-303
Five chickpea cultivars, Chitoui, Neyer, Kasseb, Beja 1 and Bouchra, were planted on three sowing dates at two Experimental
Stations in Tunisia: Bou Salem in the north and the more southerly Mornag, where the climate is drier. Severity of blight,
caused by Ascochyta rabiei, was measured on a 1–9 scale (defined) on vegetative parts and on pods as percent infected and percent infected that were
empty. At both locations, disease was essentially absent on plants sown on the third dates but present on plants sown on the
two earlier dates. At Bou Salem, disease severity was highest for the second sowing date whereas at Mornag it was highest
for the first sowing date; but for each sowing date, disease severity was lower at Mornag than at Bou Salem. Yield components
were measured as number of pods per plant, number of seeds per plant, number of seeds per 100 pods, 100 seed weight and weight
of seeds per plant. Both disease severity and yield differed significantly among sowing dates (differently at each location)
and also among cultivars for each sowing date, these differences depending both on sowing date and location. A lower yield
was always associated with a higher disease severity, although the quantitative relationship differed between cultivars and
locations. Cultivar Beja 1 had the lowest vegetative disease scores at both locations and both sowing dates 1 and 2. Beja 1
also scored well for all yield components. Plants sown on the third (latest) date gave the highest yields for all cultivars
at both locations (except for an unusually high yield of Neyer at Mornag on sowing date 2), in some instances being more than
double those from the earlier sowing dates. Thus, in contrast to other studies, late sowing did not result in yield loss. 相似文献
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Mkaouar L Endo Y Jun HX Lee SJ Jaroensong T Mochizuki M Uchida K Nakayama H Sasaki N Nakagawa T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2012,74(6):713-718
In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients. 相似文献
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Stipagrostis ciliata (Desf.) De Winter is a pastoral C4 grass grown in arid regions. This research work focused on assessing the growth of S. ciliata accessions derived from two different climate regions (a wet arid region in the Bou Hedma National Park in the central and southern part of Tunisia (coded as WA), and a dry arid region from the Matmata Mountain in the south of Tunisia (coded as DA)) under water stress conditions. Specifically, the study aimed to investigate the phenological and physiological responses of potted S. ciliata seedlings under different water treatments: T1 (200 mm/a), T2 (150 mm/a), T3 (100 mm/a) and T4 (50 mm/a). Growth phenology, net photosynthesis (Pn), stomatal conductance (gs), midday leaf water potential (Ψmd), predawn leaf water potential (Ψpd), soil water content (SWC) and soil water potential (Ψs) were observed during the water stress cycle (from December 2016 to November 2017). The obtained results showed that the highest growth potential of the two accessions (WA and DA) was recorded under treatment T1. The two accessions responded differently and significantly to water stress. Photosynthetic parameters, such as Pn and gs, decreased sharply under treatments T2, T3 and T4 compared to treatment T1. The higher water stress increased the R/S ratio (the ratio of root dry biomass to shoot dry biomass), with values of 1.29 and 2.74 under treatment T4 for accessions WA and DA, respectively. Principal component analysis (PCA) was applied, and the separation of S. ciliata accessions on the first two axes of PCA (PC1 and PC2) suggested that accession DA was detected in the negative extremity of PC1 and PC2 under treatments T1 and T2. This accession was characterized by a high number of spikes. For treatments T3 and T4, both accessions were detected in the negative extremity of PC1 and PC2. They were characterized by a high root dry biomass. Therefore, S. ciliata accessions responded to water stress by displaying significant changes in their behaviours. Accession WA from the Bou Hedma National Park (wet arid region) showed higher drought tolerance than accession DA from the Matmata Mountain (dry arid region). S. ciliata exhibits a significant adaptation capacity for water limitation and may be an important species for ecosystem restoration. 相似文献