Evaluation of concurrent perineal hernia in adult male dogs presenting with nontraumatic,acquired inguinal hernias     

Mandy L. Wallace  Janet A. Grimes  Daniel J. Duffy  Cameron Kindra  Melissa MacIver  Samantha Lin  Valery F. Scharf  Chad W. Schmiedt 《The Canadian veterinary journal. La revue veterinaire canadienne》2021,62(6):617

A possible association between the development of nontraumatic, acquired inguinal hernias (NAIH) and perineal hernias (PH) has been postulated in adult dogs. The objective of this study was to evaluate the frequency of concurrent diagnosis of PH in dogs presented with NAIH and determine potential risk factors for concurrent PH and NAIH. Medical records of adult male dogs presented for NAIH to 4 hospitals between 2007 and 2017 were retrospectively reviewed. Twenty-one dogs with NAIH were included, 8 of which had concurrent PH. There were no significant differences between dogs with and without PH; however, among dogs with both conditions, intact dogs (8.1 ± 1.4 years) were younger than neutered dogs (11.7 ± 1.0 years; P = 0.007). Thirty-eight percent of male dogs presenting for NAIH had concurrent PH, indicating that these conditions commonly occur together. Dogs presenting for NAIH should be carefully evaluated for concurrent PH before surgical intervention.  相似文献   

Open Research—What is it,and how can Equine Veterinary Journal's authors engage with Open Research initiatives?     

Mandy J. Peffers  Leah C. Webster 《Equine veterinary journal》2022,54(2):197-200

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Amino Acid Composition of Univalent Fragments of Rabbit Antibody     

Mandy WJ  Stambaugh MK  Nisonoff A 《Science (New York, N.Y.)》1963,140(3569):901-903

Univalent fragments of gamma-globulin preparations from four individual rabbits were fractionated and the amino acid compositions of end fractions were compared. For amino acids with uncharged side chains, differences were consistently less than one residue per fragment of molecular weight 50,000. There were differences in the content of amino acids, other than glutamic acid, with charged side chains; these were in the direction expected on the basis of relative strength of adherence to carboxymethyl cellulose and electrophoretic mobility. Exclusive of any possible differences in amide, the total difference in charged groups was three to four residues per fragment. Sine the net charge of univalent fragments reflects that of the gamma-globulin molecule from which the fragments are derived, corresponding differences in composition may also exist among whole gamma-globulin molecules.  相似文献   

What is your diagnosis? Juvenile-onset generalised demodicosis     

Neuber AE 《The Journal of small animal practice》2004,45(11):537, 575-537, 576

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Highly conserved protective epitopes on influenza B viruses   总被引：1，自引：0，他引：1  

C Dreyfus  NS Laursen  T Kwaks  D Zuijdgeest  R Khayat  DC Ekiert  JH Lee  Z Metlagel  MV Bujny  M Jongeneelen  R van der Vlugt  M Lamrani  HJ Korse  E Geelen  Ö Sahin  M Sieuwerts  JP Brakenhoff  R Vogels  OT Li  LL Poon  M Peiris  W Koudstaal  AB Ward  IA Wilson  J Goudsmit  RH Friesen 《Science (New York, N.Y.)》2012,337(6100):1343-1348

Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.  相似文献   

On the Current Situation of Glanders in Various Districts of the Pakistani Punjab     

Iahtasham Khan  Lothar H. Wieler  Mahboob Ahmad Butt  Mandy C. Elschner  Ashiq Hussain Cheema  Lisa D. Sprague  Heinrich Neubauer 《Journal of Equine Veterinary Science》2012

Glanders is a highly infectious and zoonotic disease of solipeds caused by Burkholderia mallei. Progressive loss of efficiency and fatal outcome resulted in massive economic losses, which forced veterinary authorities throughout the world to implement disease control measures; these measures included mass testing using the complement fixation test and/or malleinization, and the culling of positives. This led to the eradication of glanders from Western Europe and North America in the 1950s. However, in the last decade, the number of outbreaks in Asia and South America increased steadily, and glanders regained the status of a re-emerging transboundary disease. Pakistan has been an endemic country for the past 120 years, but concise data on the presence of disease are not available. A total of 533 serum samples were collected from draught equines, a suspected risk group for glanders, from various districts of Punjab in Pakistan. The complement fixation test and the highly sensitive Western blot technique were used for serodiagnosis. No animal (horse, mule, and donkey) was found to be positive for infection. Glanders seems to be restricted to remote, sporadic pockets of endemicity and may cause outbreaks after being introduced into naive populations by (asymptomatic) shedders.  相似文献   

ASVCP Guidelines: Principles of Quality Assurance and Standards for Veterinary Clinical Pathology (version 3.0)     

Jill E. Arnold  Melinda S. Camus  Kathy P. Freeman  Luca Giori  Emma H. Hooijberg  Unity Jeffery  Jrmie Korchia  Mandy J. Meindel  A Russell Moore  Sandra C. Sisson  Linda M. Vap  Jennifer R. Cook 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2019,48(4):542-618

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Pemphigus foliaceus-like drug reaction in a 3-month-old crossbreed dog treated for juvenile cellulitis     

Horvath C  Neuber A  Litschauer B 《Veterinary dermatology》2007,18(5):353-359

Two weeks after administration of routine vaccinations, a 3-month-old, male crossbreed dog developed cutaneous lesions that were clinically and histopathologically consistent with a diagnosis of juvenile cellulitis. The patient was treated with systemic antibacterial, antibacterial ophthalmic ointment and nonsteroidal anti-inflammatory drugs. Within 1 week, new skin lesions that were clinically, histopathologically and immunohistochemically consistent with pemphigus foliaceus developed. The latter completely resolved following drug withdrawal, suggesting a pemphigus foliaceus-like drug reaction. However, the initial lesions persisted and required glucocorticoid therapy to effect resolution. To the authors' knowledge, this is the first reported case of a puppy developing juvenile cellulitis followed by a pemphigus foliaceus-like reaction shortly thereafter, in response to drug therapy.  相似文献   

The challenges of effective model scoping: A FLORES case study from the mafungautsi forest margins,Zimbabwe     

Mandy Haggith  Ravi Prabhu  Happyson Mudavanhu  Frank Matose  Tendayi Mutimukuru  Richard Nyirenda  Wavell Standa-Gunda 《Small-Scale Forestry》2003,2(2):155-169

This paper explores the challenge of defining the scope of a systems model, emphasising three aspects: boundary, granularity and conceptual scope. The significance of these is illustrated by reference to a model of land-use decisions made in villages bordering on the Mafungautsi forest in Zimbabwe. The purpose of this model was to help policy players (Forestry Commission staff, non-governmental organisations, researchers and local people) to understand the impact of policy interventions on local people’s livelihoods. Scoping decisions that were made in building the Mafungautsi model were deliberately liberal, to encompass the interests of all participants in the modelling process. These decisions now present a range of serious challenges: the difficulty of model calibration, the computational expense of running simulations, and the difficulty for new users to understand the model. Facilitators of modelling teams need to consider the serious implications of giving everyone what they want and including all participants’ ideas in a model. In the long run, it may be better to be tough and reject many suggestions at the outset. The former approach is unlikely to lead to a tractable model, while the latter may ultimately offer greater satisfaction for all. We are grateful to the UK’s Department for International Development (DFID) and the European Community for financial support of this project. Thanks also to all of the ACM team who have contributed ideas on the process and content of the modelling work and who make it fun to undertake collaborative research. Thanks also to the participants in the Zimbabwe FLAC workshops for their input into the specification of the Mafungautsi model. Finally thanks to Robert Muetzelfeldt, Jasper Taylor, Jonathan Massheder, Fergus Sinclair and Jerry Vanclay for helping us to ride on the FLORES bandwagon.  相似文献   

High-flux solar-driven thermochemical dissociation of CO2 and H2O using nonstoichiometric ceria     

Chueh WC  Falter C  Abbott M  Scipio D  Furler P  Haile SM  Steinfeld A 《Science (New York, N.Y.)》2010,330(6012):1797-1801

Because solar energy is available in large excess relative to current rates of energy consumption, effective conversion of this renewable yet intermittent resource into a transportable and dispatchable chemical fuel may ensure the goal of a sustainable energy future. However, low conversion efficiencies, particularly with CO(2) reduction, as well as utilization of precious materials have limited the practical generation of solar fuels. By using a solar cavity-receiver reactor, we combined the oxygen uptake and release capacity of cerium oxide and facile catalysis at elevated temperatures to thermochemically dissociate CO(2) and H(2)O, yielding CO and H(2), respectively. Stable and rapid generation of fuel was demonstrated over 500 cycles. Solar-to-fuel efficiencies of 0.7 to 0.8% were achieved and shown to be largely limited by the system scale and design rather than by chemistry.  相似文献