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Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in
mouse perinatal development
Risa YABUSAKI Hidetomo IWANO Sumito TSUSHIMA Nanako KOIKE Naoko OHTANI Kentaro TANEMURA Hiroki INOUE Hiroshi YOKOTA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1479-1484
Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function.
BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect
reproductive organ development, brain development, metabolic disease and post-natal
behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane)
and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements
for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this
effective metabolizing system is weak in the fetus. In the present study, we demonstrated
that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in
the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the
fetus and newborn pups, and was increased to the same level as BPA post-partum. In
conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism
during the perinatal period, suggesting that the metabolism of individual Bisphenol
analogs requires assessment to properly gauge their risks. 相似文献
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Kuko Fuke Kana Takeshita Nanako Aoki Toshiyuki Fukuhara Mayumi Egusa Motoichiro Kodama Hiromitsu Moriyama 《Journal of General Plant Pathology》2011,77(4):248-252
Strains of the Japanese pear pathotype of Alternaria alternata were screened for double-stranded RNAs (dsRNAs). Four strains had several dsRNAs; strain N18 was associated with several
dsRNAs and had impaired growth phenotypes such as irregular mycelium and abnormal pigmentation. We isolated dsRNA-cured isolates
from strain N18 by single-conidium isolation. The dsRNA-cured isolates had recovered normal growth and pigmentation. Enlarged
vesicles were observed in mycelial cells of the original dsRNA-carrying N18 strain. DAPI nuclear staining revealed regression
of the nuclei in dsRNA-carrying N18 cells. These results indicate that the dsRNAs might have negative effects, such as apoptosis-like
cell death, on the host fungus. 相似文献
4.
Morphological and physiological studies on densely branched lateral roots triggered by localized phosphate in Sesbania cannabina
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下载免费PDF全文 Densely branched lateral roots (DBLRs) in Sesbania cannabina are formed in response to patchily distributed phosphorus (P) in volcanic soils. Little attention has been paid to morphological and physiological responses of DBLRs. Here, we investigated the relation between plant growth and DBLR development, enzymatic activities involved in P acquisition, and the influence of arbuscular mycorrhizal fungi (AMF), which contribute to P uptake, to clarify the function of DBLRs. We investigated DBLR development induced by localized application of P fertilizer and we compared the activities of phosphoenolpyruvate carboxylase (PEPCase) and acid phosphatase (APase) between DBLRs and non‐DBLRs. Additionally, plants were grown with or without AMF to investigate the effect of AMF colonization on the numbers of DBLRs and plant P uptake, and we compared AMF colonization between DBLRs and non‐DBLR roots. Secondary to quaternary lateral DBLRs were produced after the primary lateral roots passed near P fertilizer. Pi content per DBLR increased as DBLRs developed, promoting higher shoot growth. Under P deficiency, PEPCase and APase activities increased in non‐DBLR, but were significantly lower in DBLRs in the same plants. AMF inoculation changed the root system architecture by significantly decreasing the number of DBLRs, and AMF colonization was lower in DBLRs than in non‐DBLRs. Our results indicate that DBLR formation is a P‐coacquisition strategy of S. cannabina grown in P‐deficient andosolic soil. Roots that form DBLR are clearly different from non‐DBLR roots in morphological and biochemical response and AMF symbiosis. 相似文献
5.
Sachie Ikegami Masako Tomita Setsuko Honda Momoko Yamaguchi Reiko Mizukawa Yoko Suzuki Keiko Ishii Saeko Ohsawa Nanako Kiyooka Mitsuru Higuchi Shuhei Kobayashi 《Plant foods for human nutrition (Dordrecht, Netherlands)》1996,49(4):317-328
Barley contains approximately 10% dietary fiber and is easily cooked with rice, the dominant cereal in Japan, to increase the intake of dietary fiber. This research involved three experiments to examine the influence of barley on blood lipids in human subjects. All subjects received a boiled barley-rice (50/50 w/w mix) supplement two times per day in place of rice for 2 or 4 weeks. In the normolipemic subjects, serum lipids were unaffected by the ingestion of barley for 4 weeks. In twenty hypercholesterolemic men aged 41 ± 5 years, the ingestion of barley was associated with a significant fall in serum total cholesterol, LDL-cholesterol, phospholipids and LDL and VLDL-lipoproteins. In seven mildly hypercholesterolemic women aged 56±7 years, a significant improvement of serum lipid profiles was observed. The present study suggests the possibility that the ingestion of barley-rice could lower serum lipids in hypercholesterolemic subjects. 相似文献
6.
The effect of the seeding rate of Crotalaria spectabilis grown as green manure on the growth and nitrogen uptake of the succeeding wheat crop was examined in a pot experiment. No significant differences in the dry weight (g m?2) or nitrogen content (mg m?2) of C. spectabilis among three seeding rates [low density (LD), 1 g m?2; medium density (MD), 5 g m?2 and high density (HD), 10 g m?2] were found at 110 days after seeding. There was no significant difference in the total carbon and nitrogen contents of the incorporated material between LD plants and MD plants, values for which were both slightly higher than those for the HD plants. The C/N ratio was 20–21 in all groups of plants. Material was incorporated at a rate of 100 g fresh weight per pot filled with virgin soil. This incorporation significantly increased wheat dry weight and nitrogen uptake. However, values for HD plant incorporation were significantly lower than those for LD and MD plant incorporation at 80 and 120 days after seeding. A reduction of the dry weight and total root length of wheat grown with aqueous extracts of HD plants was found in a growth pouch experiment. 相似文献
7.
FD, a bZIP protein mediating signals from the floral pathway integrator FT at the shoot apex 总被引：5，自引：0，他引：5
Abe M Kobayashi Y Yamamoto S Daimon Y Yamaguchi A Ikeda Y Ichinoki H Notaguchi M Goto K Araki T 《Science (New York, N.Y.)》2005,309(5737):1052-1056
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Masahiro Shishido Kyoko Sato Nanako Yoshida Rie Tsukui Toshiyuki Usami 《Journal of General Plant Pathology》2010,76(1):21-30
We developed polymerase chain reaction (PCR) assays to detect and quantify Phomopsis sclerotioides, the causal agent of black root rot of cucurbits. We used internal transcribed spacers 1 and 2 of the ribosomal DNA (rDNA)
from representative isolates to search for target sequences. Primer pairs were selected after testing against 40 fungal isolates
including 13 Ph. sclerotioides isolates, 9 Phomopsis isolates other than Ph. sclerotioides, and 18 soilborne fungi that were either pathogenic or nonpathogenic to cucurbits. Conventional PCR assays with the primer
pair of CPs-1 (forward) and CPs-2 (reverse) produced target DNA amplicons from all Ph. sclerotioides isolates but none of the other isolates tested. From soil and root samples collected from fields naturally infested with
black root rot of cucumber and melon, the CPs-1/CPs-2 primer pair successfully amplified target DNA fragments in conventional
PCR assays. Moreover, we applied the CPs-1/CPs-2 primer pair in a real-time PCR assay with SYBR Green I, and PCR-amplified
products were successfully quantified by reference to a standard curve generated by adding known amounts of target DNA. Target
Ph. sclerotioides DNA fragments were similarly detected in artificially inoculated roots of cucumber, melon, pumpkin, and watermelon, but quantities
of Ph. sclerotioides DNA in their hypocotyls of the hosts varied as follows: melon ≥ cucumber ≥ watermelon > pumpkin. These results suggest that
Ph. sclerotioides infection is not species-specific but the rate of infection may differ among host species. 相似文献
9.
Effect of interleukin‐1β on occludin mRNA expression in the duodenal and colonic mucosa of dogs with inflammatory bowel disease 下载免费PDF全文
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Responses of Root Nodule Formation and Nitrogen Fixation Activity to Nitrate in a Split-Root System in Peanut (Arachis hypogaea L.) 总被引：1，自引：0，他引：1
Peanut is an important constituent of crop rotation systems with various vegetable crops, which need large amounts of inorganic nitrogen. Nitrate inhibits nodule formation and nitrogen fixation of the peanut plants in these cropping systems. To elucidate this nitrate-induced inhibition, an experimental method using a split-root system was designed and the inhibitory level of nitrate (14 m M ) was applied to half of the roots for 5 or 30 days in pot experiments. In the application of nitrate for 5 days, the dry weight, the nitrogen content, and both the number and the fresh weight of nodules for each half of the roots were unaffected by the nitrate applied to the other half. However, the nitrate induced significantly lower nitrogenase activity in the applied half. In the application for 30 days, nitrate induced a significantly higher nitrogen content in the applied half of the roots, and the inhibitory effect on nodulation and nodule development was observed not only in the applied half but also in the other half. Thus, the inhibitory effect of long-term nitrate application on the nodulation and nitrogenase activity of peanut may be systemic, but that of short-term nitrate application, in which external nitrate may regulate nitrogen fixation, may not be systemic. 相似文献