Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene     

Naoto NISHIMURA  Hiroki UEHARU  Hiroto NISHIHARA  Shiori SHIBUYA  Saishu YOSHIDA  Masashi HIGUCHI  Naoko KANNO  Kotaro HORIGUCHI  Takako KATO  Yukio KATO 《The Journal of reproduction and development》2016,62(1):93-102

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Clinical pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate after oral administration in horses     

Yamanaka T  Yamada M  Tsujimura K  Kondo T  Nagata S  Hobo S  Kurosawa M  Matsumura T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(3):293-296

The aim of this study was to investigate the pharmacokinetics of oseltamivir carboxylate (OC) in horses (n=6) after oral administration of its prodrug oseltamivir. The binding rate of OC to horse plasma proteins was negligible (<1%). Oral administration of oseltamivir of 2 mg/kg body weight of oseltamivir to horses provided a plasma concentration of OC (mean maximum concentration: 257.9 ng/ml) above the inhibitory concentrations against equine influenza A viruses determined in vitro. However, because OC is rapidly eliminated from horse plasma (mean elimination half-life: 2.5 hr), administration intervals should be less than 10 hr to retain a suitable concentration when using a single dose of 2 mg/kg oseltamivir.  相似文献   

Molecular characterization of the equine herpesvirus 1 strains RacL11 and Kentucky D     

Ghanem YM  Ibrahim el-SM  Yamada S  Matsumura T  Osterrieder N  Yamaguchi T  Fukushi H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(5):573-576

The pathogenicities of RacL11 and Kentucky D strains of equine herpesvirus 1 in the hamster infection model are different from those of Ab4p and the Japanese isolates. Virus genome restriction fragment length polymorphism analysis and sequence comparison of an intergenic region, glycoproteins and tegument genes showed higher conservation but with some strain-specific differences. These results indicate that point nucleotide differences in RacL11 and Kentucky D might be responsible for their pathogenicity in rodent models.  相似文献   

Proportions of melanocyte stimulating hormone-immunoreactive cells in the adenohypophysis of Silky fowl and hyperpigmentation-free cockerels     

Shotaro NISHIMURA  Hitomi SHIMODA  Ichiro OSHIMA  Yoshitaka ONO  Kaoru OKANO  Akira ISHIBASHI  Shoji TABATA  Hisao IWAMOTO 《Animal Science Journal》2005,76(6):575-579

Alpha‐melanocyte stimulating hormone (α‐MSH) is one of the main regulators for melanocytes, and the adenohypophysis is one of the major tissues for the synthesis of this hormone. The Silky fowl is a characteristic breed of chicken with hyperpigmentation throughout the body. The involvement of the adenohypophysis in the hyperpigmentation of this breed is not known. In the present study, the proportion of melanocyte stimulating hormone‐immunopositive cells (MSH cells) in the adenohypophysis was immunocytochemically compared between Silky, Red Cornish × New Hampshire (RN) crossbred and Japanese bantam cockerels at 15 weeks of age. After the body and gland were weighed, the adenohypophyseal cells were enzymatically dispersed and immunostained for α‐MSH, and the immunopositive MSH cells were counted. The weights of the body and adenohypophysis were heaviest in the RN crossbred, followed by the Silky and lightest in the bantam cockerels. In contrast, the ratio between adenohypophysis and bodyweight was much larger in the Silky and the bantam than in the RN crossbreed (P < 0.05). The population of MSH cells in the adenohypophysis was larger in the Silky (14.3%) than in the RN crossbreed (8.0%) and the bantam (8.1%) cockerels (P < 0.05). From these results, it was concluded that prepubertal Silky cockerel have numerous MSH cells in the adenohypophysis suggesting a relationship to hyperpigmentation.  相似文献   

Occurrence of chrysanthemum virescence caused by “<Emphasis Type="Italic">Candidatus</Emphasis> Phytoplasma aurantifolia” in Okinawa     

Takashi Naito  Minoru Tanaka  Satoshi Taba  Tesuya Toyosato  Atsushi Oshiro  Kazuko Takaesu  Kazuo Hokama  Tomio Usugi  Shinji Kawano 《Journal of General Plant Pathology》2007,73(2):139-141

In 1999, a disease of chrysanthemum [Dendranthema grandiflorum (Ramat.) Kitamura], characterized by virescence of flowers, occurred in Okinawa Prefecture. The causal agent was identified as “Candidatus Phytoplasma aurantifolia” based on 16S rDNA sequencing. The nucleotide sequence data reported are available in the DDBJ/EMBL/GenBank databases under accession number AB247462.  相似文献   

Effect of ovarian hormones on maturation of dendritic cells from peripheral blood monocytes in dogs     

Viskam WIJEWARDANA  Kikuya SUGIURA  Daluthgamage Patsy H. WIJESEKERA  Shingo HATOYA  Toshiya NISHIMURA  Ryoji KANEGI  Takahiro USHIGUSA  Toshio INABA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(7):771-775

Previously, we reported that ovarian hormones affect the immune response against E. coli isolated from the dogs affected with pyometra. In order to investigate mechanisms underlying the immune modulation, we examined the effects of ovarian hormones on the generation of dendritic cells (DCs), the most potent antigen presenting cell. DCs were differentiated from peripheral blood monocytes (PBMOs) using a cytokine cocktail. Both estrogen receptor and progesterone receptors were expressed by the PBMOs and immature DCs. When various ovarian hormones were added to the culture for the DC differentiation, progesterone significantly decreased the expression of DC maturation markers, such as CD1a, CD80 and CD86, on mature DCs. Conversely, the addition of estrogen to the cultures increased the expression of CD86, but not other maturation makers. Furthermore, DCs differentiated in the presence of progesterone did not stimulate allogeneic mononuclear cells in PB. Taken together, these results indicate that progesterone diminishes the maturation of DCs, leading to decreased immune responses against invading pathogens.  相似文献   

Expression of Krüppel-Like Factor 6, KLF6, in Rat Pituitary Stem/Progenitor Cells and Its Regulation of the PRRX2 Gene     

Hiroki UEHARU  Masashi HIGUCHI  Naoto NISHIMURA  Saishu YOSHIDA  Shiori SHIBUYA  Kenta SENSUI  Takako KATO  Yukio KATO 《The Journal of reproduction and development》2014,60(4):304-311

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A new viral epizootic of Anguilla japonica Temminck and Schlegel     

T. SANO  N. OKAMOTO  T. NISHIMURA 《Journal of fish diseases》1981,4(2):127-139

Abstract. In 1969, a new kind of epizootic occurred among eels in Japan and virological investigation was initiated. A new virus designated eel virus european (EVE) was isolated and biological, cytological, serological tests and infectivity trials were carried out. In its CPE on RTG-2 cells and additionally in its biological properties and particle size, EVE was found to be similar to infectious pancreatic necrosis virus (IPNV). Serologically, EVE was similar to the ď Honnincthun, France, strain of IPNV. However, infectivity trials showed that EVE and IPNV differed; EVE killed Japanese eels Anguilla japonica but not rainbow trout fry Salmo gairdneri , while IPN virus killed rainbow trout fry but not eels. We consider EVE to be the primary agent causing the new epizootic and propose the name viral kidney disease for the resulting clinical condition.  相似文献   

Movement of juvenile walleye pollock, Theragra chalcogramma, from a spawning ground to a nursery ground along the Pacific coast of Hokkaido, Japan     

SATOSHI HONDA  TATSUKI OSHIMA  AKIRA NISHIMURA  TSUTOMU HATTORI 《Fisheries Oceanography》2004,13(S1):84-98

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Carrier state in human acatalasemia     

NISHIMURA ET  HAMILTON HB  KOBARA TY  TAKAHARA S  OGURA Y  DOI K 《Science (New York, N.Y.)》1959,130(3371):333-334

The heterozygous carrier state of a rare hereditary disease, acatalasemia, has been defined biochemically. Affected homozygotes have no blood catalase activity, whereas heterozygotes show activities intermediate between this inactivity and the activity of normal controls, without overlap. Pedigrees show a high frequency of consanguineous marriages.  相似文献