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Dirikolu L Lehner AF Hughes C Karpiesiuk W Camargo FC Harkins JD Woods WE Bosken JM Boyles J Troppmann A Fisher M Tobin T 《Veterinary therapeutics : research in applied veterinary medicine》2003,4(4):350-363
Furosemide is a potent loop diuretic used for the prevention of exercise-induced pulmonary hemorrhage in horses. This drug may interfere with the detection of other substances by reducing urinary concentrations, so its use is strictly regulated. The regulation of furosemide in many racing jurisdictions is based on paired limits of urinary SG (<1.010) and serum furosemide concentrations (>100 ng/ml). To validate this regulatory mechanism, a liquid chromatography/mass spectrometry/mass spectrometry method employing a solid-phase extraction procedure and furosemide-d5 as an internal standard was developed. The method was used to determine the pharmacokinetic parameters of furosemide in equine serum samples and its effects on urinary SG after IV administration (250 mg) to 10 horses. Pharmacokinetic analysis showed that serum concentrations of furosemide were well described by a two-compartmental open model. Based on results in this study, it is very unlikely for horses to have serum furosemide concentrations greater than 100 ng/ml or urine SG less than 1.010 at 4 hours after administration (250 mg IV). However, it should be remembered that urine SG is a highly variable measurement in horses, and even without furosemide administration, some horses might naturally have urine SG values less than 1.010. 相似文献
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The essential oil of Turkish endemic Ziziphora taurica subsp. cleonioides aerial parts was found to contain (+)-pulegone (81.86%), limonene (4.48%) and piperitenone (2.30%) activity. The essential oil showed relevant antioxidant activity. 相似文献
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Murat Kutlu Onder Ergonul Selda Sayin-Kutlu Tumer Guven Cemal Ustun Sema Alp-Cavus Serife Barcın Ozturk Ozlem Acicbe Serife Akalin Recep Tekin Suda Tekin-Koruk Yusuf Ziya Demiroglu Ramazan Keskiner Ibak Gönen Sevil Sapmaz-Karabag Vuslat Bosnak Esra Kazak 《Preventive veterinary medicine》2014
Veterinarians and veterinary technicians are at risk for occupational brucellosis. We described the risk factors of occupational brucellosis among veterinary personnel in Turkey. A multicenter retrospective survey was performed among veterinary personnel who were actively working in the field. Of 712 veterinary personnel, 84 (11.8%) had occupational brucellosis. The median number of years since graduation was 7 (interquartile ranges [IQR], 4–11) years in the occupational brucellosis group, whereas this number was 9 (IQR, 4–16) years in the non-brucellosis group (p < 0.001). In multivariable analysis, working in the private sector (odds ratio [OR], 2.8; 95% confidence interval [95% CI], 1.55–5.28, p = 0.001), being male (OR, 4.5; 95% CI, 1.05–18.84, p = 0.041), number of performed deliveries (OR, 1.01; 95% CI, 1.002–1.02, p = 0.014), and injury during Brucella vaccine administration (OR, 5.4; 95% CI, 3.16–9.3, p < 0.001) were found to be risk factors for occupational brucellosis. We suggest that all veterinary personnel should be trained on brucellosis and the importance of using personal protective equipment in order to avoid this infection. 相似文献
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Temperature (high and low) is one of the most limiting environmental factors for growth and production of fruits in different parts of the world. For temperate-zone fruit species, a certain total heat requirements are needed in order to obtain ripe fruits. The aim of this study was to determine heat requirements of three commercial pomegranate cultivars (‘Suruc’, ‘Katirbasi’ and ‘Hicaznar’) grown in Southern Anatolia region. The cultivars showed a narrower range of heat requirements for flowering (growing degree hours, GDH), i.e. ‘Suruc’ (25,000), ‘Katirbasi’ (25,270), ‘Hicaznar’ (28,000) and a wide range of heat requirements for fruit ripening, i.e. ‘Suruc’ (73,670), ‘Katirbasi’ (74,105) and ‘Hicaznar’ (88,052) GDH. Under the Sanliurfa province conditions, two years average of effective heat summation requirement from bud swelling to 50 % flowering stage for ‘Suruc’, ‘Katirbasi’ and ‘Hicaznar’ cultivars are calculated as 643, 655 and 718 growing degree days (GDD) and from bud swelling to harvest are 2734, 2802 and 3289 GDD. It can be concluded that the effective heat summation of Sanliurfa province is enough for commercial growing for all pomegranate cultivars. 相似文献
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Effect of Water Stress at Various Growth Stages on Some Quality Characteristics of Winter Wheat 总被引：8，自引：0，他引：8
A field experiment was carried out in Erzurum (Turkey) on winter wheat to analyse the effect of water stress at different growth stages – fully irrigated (FI), rainfed (R), early water stress (EWS), late water stress (LWS) and continuous water stress (CWS), on some quality characteristics – in the 1995–96 and 1996–97 cropping seasons. Water stress had a substantial effect on most of the quality characteristics. As averages of cropping seasons, CWS, EWS, R and LWS treatments decreased grain yields by 65.5, 40.6, 30.5 and 24.0 %, respectively, compared with the FI treatment. CWS increased grain protein content by 18.1 %, sedimentation volume by 16.5 %, wet gluten content by 21.9 % and decreased 1000‐kernel weight by 7.5 g compared with FI treatment. LWS caused an increase of 8.3 % in grain protein content, 8.7 % in sedimentation volume, 10.8 % in wet gluten content and a reduction of 3.8 g in 1000‐kernel weight compared with FI. EWS and R increased sedimentation volume and wet gluten content, but decreased 1000‐kernel weight compared with FI. The effect of LWS on grain quality was more significant than that of EWS. The results suggest that soil moisture conditions increase grain yield and kernel weight of winter wheat but decrease its quality. 相似文献
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Growth and Yield Response of Facultative Wheat to Winter Sowing, Freezing Sowing and Spring Sowing at Different Seeding Rates 总被引：1，自引：0，他引：1
Growth and yield of wheat are affected by environmental conditions and can be regulated by sowing time and seeding rate. In this study, three sowing times [winter sowing (first week of September), freezing sowing (last week of October) and spring sowing (last week of April)] at seven seeding rates (325, 375, 425, 475, 525, 575 and 625 seeds m?2) were investigated during the 2002–03 and 2003–04 seasons, in Erzurum (Turkey) dryland conditions, using Kirik facultative wheat. A split‐plot design was used, with sowing times as main plots and seeding rates randomized as subplots. There was a significant year × sowing time interaction for grain yield and kernels per spike. Winter‐sown wheat produced a significantly higher leaf area index, leaf area duration, spikes per square metre, kernel weight and grain yield than freezing‐ and spring‐sown wheat. The optimum time of sowing was winter for the facultative cv. Kirik. Grain yields at freezing and spring sowing were low, which was largely the result of hastened crop development and high temperatures during and after anthesis. Increasing seeding rate up to 525 seeds m?2 increased the spikes per square metre at harvest, resulting in increased grain yield. Seeding rate, however, was not as important as sowing time in maximizing grain yield. Changes in spikes per square metre were the major contributors to the grain‐yield differences observed among sowing times and seeding rates. Yield increases from higher seeding rates were greater at freezing and spring sowing. We recommended that a seeding rate of 525 seeds m?2 be chosen for winter sowing, and 575 seeds m?2 for freezing and spring sowing. 相似文献
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Beytut E Kilic E Ozturk S Ozba B 《The Canadian veterinary journal. La revue veterinaire canadienne》2006,47(4):349-351
The pathologic features of a nasal chondrosarcoma, a rare tumor of bovines, in a Simmental cow are described. Upon clinical examination, stertor, difficulty in breathing, poor body condition, and a nasal mass were found. Histopathologic examination revealed that the mass was composed mostly of numerous cartilaginous lobules surrounded by spindle-shaped cells, often showing mitotic figures, atypical chondrocytes, and lacunae containing 2 or more cells. On the basis of the histological features, the mass was diagnosed as a nasal chondrosarcoma. 相似文献
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Abstract AIM: To determine the pharmacokinetics and bioavailability of florfenicol in the plasma of healthy Japanese quail (Coturnix japonica). METHODS: Sixty-five quail were given an I/V and I/M dose of florfenicol at 30 mg/kg bodyweight (BW). A two-period sequential design was used, with a wash-out period of 2 weeks between the different routes of administration. Concentrations of florfenicol in plasma were determined using high-performance liquid chromatography (HPLC). RESULTS: A naíve pooled data analysis approach for the plasma concentration-time profile of florfenicol was found to fit a non-compartmental open model. After I/V administration, the mean residence time (MRT), mean volume of distribution at steady state (Vss), and total body clearance of florfenicol were 12.0 (SD 0.37) h, 8.7 (SD 0.22) L/kg, and 1.3 (SD 0.08) L/h/kg, respectively. After I/M injection, the MRT, mean absorption time (MAT), and bioavailability were 12.3 (SD 0.37) h, 0.2 (SD 0.02) h, and 79.1 (SD 1.79)%, respectively. CONCLUSIONS: The time for the concentration of florfenicol to fall below the probable effective concentration of 1 µg/ml of approximately 10 h is sufficient for the minimum inhibitory concentration needed for many bacterial isolates. Further pharm acodynamic studies in quail are needed to evaluate a suitable dosage regimen. 相似文献