THE RENAL REGULATION OF ACID BASE BALANCE WITH SPECIAL REFERENCE TO THE MECHANISM FOR ACIDIFYING THE URINE. II     

Pitts RF 《Science (New York, N.Y.)》1945,102(2639):81-85

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THE RENAL REGULATION OF ACID BASE BALANCE WITH SPECIAL REFERENCE TO THE MECHANISM FOR ACIDIFYING THE URINE     

Pitts RF 《Science (New York, N.Y.)》1945,102(2638):49-54

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Enhancement of photochemical smog by n,n'-diethylhydroxylamine in polluted ambient air     

Pitts JN  Smith JP  Fitz DR  Grosjean D 《Science (New York, N.Y.)》1977,197(4300):255-257

A recent proposal for controlling photochemical smog by the addition to ambient air of 0.03 to 0.05 part per million of diethylhydroxylamine (DEHA) is shown to be invalid. The addition of DEHA in the range of 0.05 to 0.5 part per million to ambient air irradiated with sunlight in a dual outdoor environmental chamber caused marked increases in the rates of formation and concentrations of ozone, peroxyacetyl nitrate, and light-scattering particles.  相似文献   

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding   总被引：1，自引：0，他引：1  

S P Wood  I J Tickle  A M Treharne  J E Pitts  Y Mascarenhas  J Y Li  J Husain  S Cooper  T L Blundell  V J Hruby 《Science (New York, N.Y.)》1986,232(4750):633-636

Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.  相似文献   

Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression     

Egloff S  O'Reilly D  Chapman RD  Taylor A  Tanzhaus K  Pitts L  Eick D  Murphy S 《Science (New York, N.Y.)》2007,318(5857):1777-1779

RNA polymerase II (Pol II) transcribes genes that encode proteins and noncoding small nuclear RNAs (snRNAs). The carboxyl-terminal repeat domain (CTD) of the largest subunit of mammalian RNA Pol II, comprising tandem repeats of the heptapeptide consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7, is required for expression of both gene types. We show that mutation of serine-7 to alanine causes a specific defect in snRNA gene expression. We also present evidence that phosphorylation of serine-7 facilitates interaction with the snRNA gene-specific Integrator complex. These findings assign a biological function to this amino acid and highlight a gene type-specific requirement for a residue within the CTD heptapeptide, supporting the existence of a CTD code.  相似文献   

CONSTANT TEMPERATURE APPARATUS ADAPTED FOR USE ON THE MICROSCOPE STAGE     

Pitts RF 《Science (New York, N.Y.)》1932,76(1983):626-627

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Use of a fiberoptic accessory for retrieval of adult heartworms in a dog with postcaval syndrome     

P E Howard  R P Pitts 《Journal of the American Veterinary Medical Association》1986,189(10):1343-1344

Use of a spiral fiberoptic basket for the removal of adult heartworms from the vena cava and right atrium of a dog with postcaval syndrome is described. Complications reported with the use of alligator forceps were not encountered with the basket.  相似文献   

Veterinary student projects competing in the Hill's and the DHHS Secretary's Award Writing Competitions     

Hendrix CM  Thompson I  Pitts JL  McClelland CL  Pence PA 《Journal of veterinary medical education》2003,30(1):78-80

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Insecticidal activity of N-arylalkylbenzhydrolpiperidines     

Wierenga JM  Warkentin DL  Staetz CA  Pitts DL  Dybas JA 《Pest management science》2002,58(12):1266-1272

Benzhydrolpiperidine (BZP) insecticides represent a novel class of chemistry. Their specificity and efficacy as well as their low mammalian toxicity give them excellent potential for commercialization. Several N-arylalkylbenzhydrolpiperidines were tested for activity against a variety of insects in the laboratory and greenhouse. These tests were used to select compounds for field trials and determine rates of application for field tests. The BZP compounds have good activity against Lepidoptera, with modest Coleoptera activity. They are toxic by oral administration and have about 100-fold lower activity by topical exposure. A methyl carbamate BZP, F4265, was the most active compound, with LC50 values of 6 mg litre(-1) or less for most Lepidopteran species tested. F4265 was active in a variety of field trials at 112-224gAI ha(-1). Whole-plant testing methods conducted in the greenhouse were effective in determining field test rates.  相似文献   

"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide     

Pitts JN  Lokensgard DM  Ripley PS  VAN Cauwenberghe KA  VAN Vaeck L  Shaffer SD  Thill AJ  Belser WL 《Science (New York, N.Y.)》1980,210(4476):1347-1349

Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.  相似文献