Effects of gossypol from cottonseed cake on the blood profile in sheep     

Antônio Carlos Lopes Câmara  André Menezes do Vale  Cláudio Roberto Scabelo Mattoso  Marília Martins Melo  Benito Soto-Blanco 《Tropical animal health and production》2016,48(5):1037-1042

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Evaluation of von Willebrand Factor During Pregnancy,Lactation and Oestrous Cycle in Bitches Affected and Unaffected by von Willebrand Disease     

CRS Mattoso  RK Takahira  SL Beier  JP Araujo Jr  JE Corrente 《Reproduction in domestic animals》2013,48(3):416-422

Plasmatic concentrations of von Willebrand Factor (vWF) increase during pregnancy in humans and dogs; however the mechanism of such increase is still not well defined. The aims of this study were: (i) to evaluate changes in vWF concentration during pregnancy and during the subsequent oestrous cycle in bitches affected and unaffected by von Willebrand Disease (vWD); (ii) to correlate the vWF levels and cortisol levels in both groups. Seven vWD affected (GI) and nine unaffected (GII) bitches were used. The animals were assessed during pregnancy, parturition, lactation and non‐gestational oestrous cycle in 11 moments (Pregnancy 1, Pregnancy 2, Parturition, Lactation 1, Lactation 2, Lactation 3, Anestrus, Proestrus, Oestrus, Diestrus 1, and Diestrus 2). The following tests were performed; measurement of von Willebrand factor antigen (vWF:Ag), albumin and cortisol. In both groups, vWF concentration remained stable during the non‐gestational oestrous cycle, but increased during pregnancy, with the highest value observed at parturition. Increases of 70% and 124% in vWF were seen in GI and GII, respectively, compared to anestrus. No correlation was found between vWF and cortisol. Values of vWF:Ag changed during pregnancy, with a peak at parturition, both in vWD affected and unaffected animals. Values of vWF were not altered in the different phases of the oestrous cycle following pregnancy in both groups. Evaluation of vWF during pregnancy can cause false negative results for vWD, but assessment can be performed at any point in the oestrous cycle of non‐pregnant bitches.  相似文献   

Hemodynamic effects of target-controlled infusion of propofol alone or in combination with a constant-rate infusion of remifentanil in dogs     

Suzane L. Beier  Cláudio R.S. Mattoso  Antonio J.A. Aguiar  Pedro T.G. Vianna  Flavio Massone 《Canadian journal of veterinary research》2015,79(4):309-315

The objective of this study was to evaluate the hemodynamic effects of target-controlled infusion (TCI) of propofol alone or in combination with a constant-rate infusion (CRI) of remifentanil. Six adult dogs were given 2 treatments in a randomized crossover study with a 7-day interval between treatments. Treatment 1 was propofol (P) and treatment 2 was propofol and remifentanil (P-Rem), without any premedication. Propofol was induced using a TCI system with a predicted plasma concentration (Cp) of 6.0 μg/mL. Anesthesia was maintained within the Cp range (0.65 to 3.0 μg/mL) for 120 min and remifentanil was administered at a rate of 0.3 μg/kg body weight (BW) per minute, CRI. Cardiopulmonary variables were recorded before (baseline), during, and 120 min after drug administration. Heart rate (HR) decreased significantly in the P-Rem group (46%) compared with baseline values. In the P-Rem group, the cardiac index (CI) decreased significantly (49% to 58%) and the stroke volume (SV) decreased compared with baseline values. The systemic vascular resistance index (SVRI) increased significantly in the P-Rem group compared with baseline values. There was no difference in mean arterial pressure (MAP) between the groups. Central venous pressure (CVP) and pulmonary artery occlusion pressure (PAOP) significantly increased in the P-Rem group compared with baseline values. In conclusion, the hemodynamic changes observed in this study indicate a compromise of the cardiovascular system, although the dogs in this study were healthy/euvolemic and there was no change in preload. More studies are required in order to evaluate the actual safety of the combination of propofol and remifentanil in patients with reduced cardiac reserve.  相似文献   

Preparation and characterization of novel micro- and nanocomposite hydrogels containing cellulosic fibrils     

Aouada FA  de Moura MR  Orts WJ  Mattoso LH 《Journal of agricultural and food chemistry》2011,59(17):9433-9442

The main objective of this article was to report a simple, fast, and low cost strategy for the synthesis of micro- and nanocomposites by adding cellulose nanofibers, obtained by acid hydrolysis, and added to hydrogels as reinforcing agents. Specifically, when cellulose nanofibers were added to hydrogels, morphologic analyses showed significant decreases in pore size and formation of three-dimensional well-oriented porous microstructure. It was also observed that cellulose nanoparticles improved the mechanical and structural network properties without negatively impacting their thermal and hydrophilic properties. The value of maximum compressive stress was 2.1 kPa for the PAAm-MC, and it increased to 4.4 kPa when the cellulose nanofiber was incorporated into the hydrogel. By investigation of XRD patterns, it was found that the incorporation of cellulose nanofiber affected the crystallinity of PAAm-MC hydrogels, thus contributing to improvements in mechanical, structural, and hydrophilic properties of the PAAm-MC hydrogels.  相似文献   

Sugarcane bagasse whiskers: Extraction and characterizations     

Eliangela de Morais TeixeiraThalita Jessika Bondancia  Kelcilene Bruna Ricardo Teodoro  Ana Carolina CorrêaJosé Manoel Marconcini  Luiz Henrique Caparelli Mattoso 《Industrial Crops and Products》2011,33(1):63-66

This work evaluates the use of sugarcane bagasse (SCB) as a source of cellulose to obtain whiskers. These fibers were extracted after SCB underwent alkaline peroxide pre-treatment followed by acid hydrolysis at 45 °C. The influence of extraction time (30 and 75 min) on the properties of the nanofibers was investigated. Sugarcane bagasse whiskers (SCBW) were analyzed by transmission electron microscopy (TEM), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) in air atmosphere. The results showed that SCB could be used as source to obtain cellulose whiskers and they had needle-like structures with an average length (L) of 255 ± 55 nm and diameter (D) of 4 ± 2 nm, giving an aspect ratio (L/D) around 64. More drastic hydrolysis conditions (75 min) resulted in less thermally stable whiskers and caused some damage on the crystal structure of the cellulose as observed by XRD analysis.  相似文献   

Properties of thermoplastic starch from cassava bagasse and cassava starch and their blends with poly (lactic acid)     

Eliangela de M. TeixeiraAntônio A.S. Curvelo  Ana C. CorrêaJosé M. Marconcini  Gregory M. GlennLuiz H.C. Mattoso 《Industrial Crops and Products》2012,37(1):61-68

Cassava bagasse is an inexpensive and broadly available waste byproduct from cassava starch production. It contains roughly 50% cassava starch along with mostly fiber and could be a valuable feedstock for various bioproducts. Cassava bagasse and cassava starch were used in this study to make fiber-reinforced thermoplastic starch (TPS_B and TPS_I, respectively). In addition, blends of poly (lactic acid) and TPS_I (20%) and TPS_B (5, 10, 15, 20%) were prepared as a means of producing low cost composite materials with good performance. The TPS and PLA blends were prepared by extrusion and their morphological, mechanical, spectral, and thermal properties were evaluated. The results showed the feasibility of obtaining thermoplastic starches from cassava bagasse. The presence of fiber in the bagasse acted as reinforcement in the TPS matrix and increased the maximum tensile strength (0.60 MPa) and the tensile modulus (41.6 MPa) compared to cassava starch TPS (0.40 and 2.04 MPa, respectively). As expected, blending TPS with PLA reduced the tensile strength (55.4 MPa) and modulus (2.4 GPa) of neat PLA. At higher TPS_B content (20%) the maximum strength (19.9 MPa) and tensile modulus (1.7 GPa) were reduced about 64% and 32%, respectively, compared to the PLA matrix. In comparison, the tensile strength (16.7) and modulus (1.2 GPa) of PLA blends made with TPS_I were reduced 70% and 51% respectively. The fiber from the cassava bagasse was considered a filler since no increase in tensile strength of PLA/TPS blends was observed. The TPS_I (33.1%) had higher elongation to break compared to both TPS_B (4.9%) and PLA (2.6%). The elongation to break increased from 2.6% to 14.5% by blending TPS_I with PLA. In contrast, elongation to break decreased slightly by blending TPS_B with PLA. Thermal analysis indicated there was some low level of interaction between PLA and TPS. In PLA/TPS_B blends, the TPS_B increased the crystallinity of the PLA component compared to neat PLA. The fiber component of TPS_B appeared to have a nucleating effect favoring PLA crystallization.  相似文献   

Hematological and splenic Doppler ultrasonographic changes in dogs sedated with acepromazine or xylazine     

Dienifer V. Sutil  Cláudio R.S. Mattoso  Julieta Volpato  Nádia C. Weinert  Ádson Costa  Rozyanne R. Antunes  Thiago R. Muller  Suzane L. Beier  Ronise Tochetto  Felipe Comassetto  Mere E. Saito 《Veterinary anaesthesia and analgesia》2017,44(4):746-754

Objective

To evaluate the onset and duration of hematological changes and the use of Doppler ultrasound (spleen) in dogs sedated with acepromazine or xylazine.

Study design

Clinical study.

Animals

A total of 24 mixed breed dogs aged 1–4 years and weighing 15–25 kg.

Methods

Dogs were randomly distributed into two groups: acepromazine group (AG) which were administered acepromazine (0.05 mg kg^?1) intramuscularly and xylazine group (XG) administered xylazine (0.5 mg kg^?1) intramuscularly. Sonographic evaluations (morphologic and hemodynamic splenic vascularization) and hematologic tests were performed before drug administration (baseline) and 5, 15, 30, 60, 120, 240, 360, 480 and 720 minutes after drug administration.

Results

A significant reduction occurred in erythrogram variables in AG at 15–720 minutes corresponding with a significant enlargement of the spleen. In XG, a significant reduction was observed in the erythrogram variables at 30–60 minutes without a significant enlargement of the spleen. Hilar diameter did not change over time in either group. Flow alterations were found only in the splenic artery in AG, with a decreased final diastolic velocity observed at 60–120 minutes.

Conclusions

Administration of acepromazine resulted in decreased red blood cell count, hemoglobin, packed cell volume and an increased diameter of the spleen. Xylazine administration resulted in similar hematologic changes but of smaller magnitude and duration and without splenic changes. The absence of significant changes in the Doppler flow parameters of the splenic artery and vein and the hilar diameter suggests that the splenomegaly that was observed in AG was not due to splenic vasodilation. No splenic sequestration occurred after xylazine administration.

Clinical relevance

The results indicate that acepromazine decreases the erythrocyte concentrations by splenic erythrocyte sequestration and concomitant splenomegaly. Xylazine can cause slight hematologic changes, but without splenic changes.  相似文献