Antiwar statement     

Noyes P 《Science (New York, N.Y.)》1971,173(3996):475

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Oestradiol Induced Inhibition of Neuroendocrine Marker Expression in Leydig Cells of Adult Rats     

HH Ortega  NR Salvetti  C Baravalle  JA Lorente  GA Mira 《Reproduction in domestic animals》2006,41(3):204-209

The objectives of this work were to determine the changes in the expression of neuroendocrine markers in Leydig cell by oestradiol treatment, and to determine whether testosterone is able to recover partially the effects of hormonal suppression induced by oestradiol. Adult male rats were injected daily with either 50 microg of oestradiol or oestradiol plus testosterone propionate (25 mg every 3 days) for 15 days. The animals were sacrificed and testicles were dissected and processed by routine histological protocols. FSH and LH serum levels were determined by radioimmunoassay. The visualization of antigens was achieved by the streptavidin-peroxidase immunohistochemical method. Antibodies against chromogranin A (CrA), S-100 protein (S-100), P substance (PS), synaptofisin (SYN), neurofilament protein (NF), gliofibrillary acidic protein (GFAP) and neuron specific enolase (NSE) were used. The mean LH and FSH serum concentrations were consistently suppressed with hormonal treatments. Intermediate filaments (NF and GFAP) showed no difference in their expression. The expression of S-100, NSE and SYN was significantly lower in both hormone-treated groups. In oestradiol-treated rats, the immunoreactivity of CrA and SP decreased significantly but was restored after testosterone supplementation. Although the nature and functions of many of these substances in Leydig cells remain unknown, these results are consistent with the hypothesis that the expression of some neuroendocrine markers is hormonally controlled.  相似文献   

A TALK ON TEACHING     

Noyes AA 《Science (New York, N.Y.)》1908,28(724):657-665

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THE CONTRIBUTION OF CHEMISTRY TO MODERN LIFE     

Noyes WA 《Science (New York, N.Y.)》1907,26(673):706-714

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THE CARNEGIE INSTITUTION     

Mezes SE  Sternberg CH  Johnson RH  Noyes WA 《Science (New York, N.Y.)》1902,16(416):978-979

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REPORTING MOISTURE RESULTS     

Noyes HA 《Science (New York, N.Y.)》1918,47(1212):293-295

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CULTIVATION AND SOIL MOISTURE     

Noyes HA 《Science (New York, N.Y.)》1922,55(1432):610-611

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PRESENT PROBLEMS OF ORGANIC CHEMISTRY     

Noyes WA 《Science (New York, N.Y.)》1904,20(511):490-501

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VALENCE     

Noyes WA 《Science (New York, N.Y.)》1919,49(1260):175-182

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Experimental oral transmission of largemouth bass virus     

J E Woodland  C J Brunner  A D Noyes  J M Grizzle 《Journal of fish diseases》2002,25(11):669-672

Largemouth bass virus (LMBV) is a recently discovered iridovirus that causes a fatal disease of largemouth bass, Micropterus salmoides (Lacepède). Fish can become infected by waterborne LMBV, but oral transmission of this virus has not been demonstrated previously. Largemouth bass were gavaged with guppies, Poecilia reticulata Peters, which had been injected with LMBV, and then sampled periodically during a 7‐week observation period. The dose of LMBV averaged 10^5.6 tissue culture infectious doses – 50% cytopathic endpoint (TCID₅₀) per largemouth bass. Five of 24 largemouth bass exposed to LMBV became infected with the virus, but none of the fish had clinical signs typical of LMBV disease. Virus titres in largemouth bass were highest in swim bladder (10^5.5–9.5 TCID₅₀ g^?1) and were 10^5.2 TCID₅₀ g^?1 or lower in cutaneous mucus, head kidney, trunk kidney, spleen, gonad and intestine. These results indicate that LMBV can be transmitted orally to largemouth bass, but further study is needed to determine the factors affecting pathogenicity of the virus.  相似文献