Dermoid cysts in camels     

N R Purohit  D S Chouhan  P R Dudi  U K Vyas 《The British veterinary journal》1989,145(1):89-90

In our experience the camel (Camelus dromedarius) seems to be affected more commonly by dermoid cysts as compared to other cutaneous cysts. However, apart from one reference (Monteverde, 1935), the dermoid cyst has not been reported in the camel. This report documents dermoid cysts in identical locations in 11 camels with two camels having bilateral dermoid cysts at the similar site.  相似文献   

Equol,a Blood–Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein,Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans     

Johnson  Shelby L.  Park  Hyun Y.  Vattem  Dhiraj A.  Grammas  Paula  Ma  Hang  Seeram  Navindra P. 《Plant foods for human nutrition (Dordrecht, Netherlands)》2020,75(4):512-517

Plant Foods for Human Nutrition - Emerging data support that plant food based isoflavones have ameliorating effects on a variety of neurodegenerative diseases including Parkinson’s disease...  相似文献   

Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid Species Aurantiochytrium limacinum Using Bioinformatics Approach     

Sachin Vyas  Maurizio Bettiga  Ulrika Rova  Paul Christakopoulos  Leonidas Matsakas  Alok Patel 《Marine drugs》2022,20(3)

The marine microorganisms thraustochytrids have been explored for their potential in the production of various bioactive compounds, such as DHA, carotenoids, and squalene. Squalene is a secondary metabolite of the triterpenoid class and is known for its importance in various industrial applications. The bioinformatic analysis for squalene synthase (SQS) gene (the first key enzyme in the tri-terpenoid synthesis pathway), that is prevailing among thraustochytrids, is poorly investigated. In-silico studies combining sequence alignments and bioinformatic tools helped in the preliminary characterization of squalene synthases found in Aurantiochytrium limacinum. The sequence contained highly conserved regions for SQS found among different species indicated the enzyme had all the regions for its functionality. The signal peptide sequence and transmembrane regions were absent, indicating an important aspect of the subcellular localization. Secondary and 3-D models generated using appropriate templates demonstrated the similarities with SQS of the other species. The 3-D model also provided important insights into possible active, binding, phosphorylation, and glycosylation sites.  相似文献   

Deoxyribonuclease in buffalo and cattle bull semen.     

F S Chauhan  P K Dwarkanath  K K Vyas 《The Indian veterinary journal》1975,52(1):12-13

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Studies on the production relations of deciduous forests of semi-arid zone of rajasthan (India)     

R. K. Garg  M. P. S. Ranawat  L. N. Vyas 《European Journal of Forest Research》1972,91(1):357-364

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Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake     

Heald AH  Sharma R  Anderson SG  Vyas A  Siddals K  Patel J  Bhatnagar D  Prabharkaran D  Rudenski A  Hughes E  Durrington P  Gibson JM  Cruickshank JK 《Public health nutrition》2005,8(6):620-627

BACKGROUND: The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease. OBJECTIVE: We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate. DESIGN, SUBJECTS AND SETTING: Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n=205) compared with people still resident in the same villages of origin in India (n=246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured. RESULTS: Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1-153.6) vs. 100.9 (94.6-107.3) ng ml(-1); F=76.6, P<0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9-33.0) vs. 56.5 (50.6-62.5) microg l(-1); F=48.4, P<0.001). At both sites, IGF-I correlated positively with total energy (Spearman's rho=0.45, P<0.001) and total fat (rho=0.44, P<0.001) as did IGFBP-3 with total energy (rho=0.21, P<0.05) and fat (rho=0.26, P<0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (rho=-0.27, P<0.001) and fat intake (rho=-0.26, P<0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (beta=0.42, P=0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose. CONCLUSION: In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.  相似文献   

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance   总被引：3，自引：0，他引：3  

Niess JH  Brand S  Gu X  Landsman L  Jung S  McCormick BA  Vyas JM  Boes M  Ploegh HL  Fox JG  Littman DR  Reinecker HC 《Science (New York, N.Y.)》2005,307(5707):254-258

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.  相似文献   

Hemagglutination assay for antigen and antibody associated with viral hepatitis   总被引：58，自引：0，他引：58  

G N Vyas  N R Shulman 《Science (New York, N.Y.)》1970,170(955):332-333

Hemagglutination assays are described for measuring hepatitis-associated Australia antigen and antibody. Red cells coated with isolated antigen, with chromic chloride as a coupling agent, are used for detection of antibodies. Detection of the antigen in serums depends on inhibition of hemagglutination. The test has the sensitivity and rapidity of the best tests available, is simpler to perform, and lends itself to large-scale screening of blood donors.  相似文献   

Sugar and signal-transducer binding sites of the Escherichia coli galactose chemoreceptor protein   总被引：11，自引：0，他引：11  

N K Vyas  M N Vyas  F A Quiocho 《Science (New York, N.Y.)》1988,242(4883):1290-1295

D-galactose-binding (or chemoreceptor) protein of Escherichia coli serves as an initial component for both chemotaxis towards galactose and glucose and high-affinity active transport of the two sugars. Well-refined x-ray structures of the liganded forms of the wild-type and a mutant protein isolated from a strain defective in chemotaxis but fully competent in transport have provided a molecular view of the sugar-binding site and of a site for interacting with the Trg transmembrane signal transducer. The geometry of the sugar-binding site, located in the cleft between the two lobes of the bilobate protein, is novel in that it is designed for tight binding and sequestering of either the alpha or beta anomer of the D-stereoisomer of the 4-epimers galactose and glucose. Binding specificity and affinity are conferred primarily by polar planar side-chain residues that form intricate networks of cooperative and bidentate hydrogen bonds with the sugar substrates, and secondarily by aromatic residues that sandwich the pyranose ring. Each of the pairs of anomeric hydroxyls and epimeric hydroxyls is recognized by a distinct Asp residue. The site for interaction with the transducer is about 18 A from the sugar-binding site. Mutation of Gly74 to Asp at this site, concomitant with considerable changes in the local ordered water structures, contributes to the lack of productive interaction with the transmembrane signal transducer.  相似文献   

Assessment of Genetic Diversity in Feronia limonia (L.) Swingle Using Inter Simple Sequence Repeats     

Shailendra Vyas  Anupama Gaur  Akhilesh K. Tyagi 《Journal of Sustainable Forestry》2013,32(3):328-342

ABSTRACT

Genetic variation was studied in threatened natural populations of Feronia limonia (Rutaceae). Samples were collected from 3 populations located in the Aravalli mountain range of south-east Rajasthan, India. Using 25 Inter Simple Sequence Repeat (ISSR) primer combinations, significant diversity was characterized among the individuals. Analysis of Molecular Variance (AMOVA) revealed that diversity is partitioned mainly within population components (80%). F statistics showed that low but significant amount of gene flow is taking place between populations (φ_ST = 0.21, P < .001). The study highlights the utility of ISSRs in assessing diversity of populations that are fragmented or limited in size.  相似文献