Resident Dendritic Cells in the Epidermis: Langerhans Cells, Merkel Cells and Melanocytes     

STEPHEN D. WHITE  JULIE A. YAGER† 《Veterinary dermatology》1995,6(1):1-8

Résumé— En plus des kératinocytes, l'épiderme contient des cellules résidentes de morphologie dendritique. Ce sont principalement la cellule de Langerhans, la cellule de Merkel et le mélanocyte. Ces cellules ont des fonctions diverses dans le tégument. Le mélanocyte assure la pigmentation cutanée et la protection contre les radiations U.V., et pourrait intervenir également dans la modulation de l'inflammation cutanée. La cellule de Langerhans intervient dans la surveillance immunologique des surfaces corporelles ecternes. La cellule de Merkel a des fonctions neuroendocrines. Cet article donne un aperçu de la structure et de la fonction de ces trois importantes populations cellulaires dans la peau. [Resident dentritic cells in the epidermis: Langerhans cells, Merkel cells and melanocytes (Cellules dentritiques résidentes de l'épiderme: cellules de Langerhans, cellules de Merkel et mélanocytes). Resumen— La epidermis contiene, además de los queratinocitos, células résidentes de morfologia dendria dendritica. Estas son principalmente las células de Langerhans, las células de Merkel y los melanocitos. Estas células tienen varias funciones en el integumento. Los melanocitos se encargan de la pigmentación y protección de la piel contra la radiación ultravioleta y tarrtbién participan en la regulación de la inflamación cutánea. Las células de Langerhans ayudan en la regulación inmunológica en la superficie externa. Las células de Merkel tienen funciones neuroendocrinas. Esta revisión da un repaso general a la estructura y función de tres importantes células de la piel. [Resident dendsuitic cells in the epidermis: Langerhans cells, Merkel cells and Melanocytes (Células résidentes en la epidermis: células de Langerhans, células de Merkel y melanocitos). Abstract— In addition to the keratinocytes, the epidermis contains resident cells of dendritic morphology. These are principally the Langerhans cell, Merkel cell and melanocyte. These cells have a number of different functions in the integument. The melanocyte is responsible for skin pigmentation and protection against UV radiation, and may also play a role in the modulation of cutaneous inflammation. The Langerhans cell aids in the immunological monitoring of the body's external surfaces. The Merkel cell has neuroendocrine functions. This review gives an overview of the structure and function of these three important cells of the skin.  相似文献   

Canine CYP2B11 metabolizes and is inhibited by anesthetic agents often co-administered in dogs     

M. T. BARATTA  M. J. ZAYA  J. A. WHITE  & C. W. LOCUSON 《Journal of veterinary pharmacology and therapeutics》2010,33(1):50-55

Baratta, M. T., Zaya, M. J., White, J. A., Locuson, C. W. Canine CYP2B11 metabolizes and is inhibited by anesthetic agents often co-administered in dogs. J. vet. Pharmacol. Therap. 33 , 50–55.
Medetomidine is a well-established sedative and analgesic for dogs and cats. As a premedicant for anesthesia regimens that also include other agents, medetomidine can also provide a dose-sparing effect. While there are likely several reasons for the dose-sparing effect of medetomidine, the role of metabolic drug–drug interactions at the single enzyme level has not yet been examined. Using a panel of individually expressed canine cytochromes P450 cloned from beagle liver, this report demonstrates that medetomidine is an extremely potent CYP2B11 inhibitor (IC₅₀ < 10 n m ) and that ketamine and midazolam are CYP2B11 substrates with high intrinsic clearances. These in vitro findings suggest that under some circumstances, medetomidine (i.e. 'perpetrator') may inhibit the metabolic clearance of some high metabolic clearance drugs (i.e. 'victims') with which it is commonly co-administered via the CYP2B11 pathway. However, as the dose-sparing effect of medetomidine premedication commonly results in anesthetic dose reduction, any increased plasma concentrations of victim drugs caused by medetomidine would still be lower than if no dose reduction had been made. Further studies are needed to characterize whether medetomidine possesses the potential to cause pharmacokinetic interactions. In conclusion, the ability of recombinant P450s to define canine-specific drug clearance pathways and P450 inhibitors should prove useful in identifying drug combinations that may require dose adjustments in dogs.  相似文献   

A third cryptic virus in beet (Beta vulgaris)     

W. S. XIE  J. F. ANTONIW  R. F. WHITE  R. D. WOODS 《Plant pathology》1993,42(3):465-470

Japanese leaf beet Beta vulgaris var. cicla cv. Fudanso plants were found to contain four double-stranded RNA (dsRNA) components in apparently healthy beet plants. Two were identified as from beet cryptic virus 1 (BCV1), but the other two showed different mobilities on gel electrophoresis and were transcribed into complementary DNA (cDNA) and cloned. Hybridization analysis showed no significant sequence homology between these two dsRNAs and the dsRNA components of BCV1 or the other known cryptic virus of beet, BCV2. Slot- and dot-blot hybridization were used with cDNA clones as probes to identify plants containing these two dsRNA components. Virus particles were purified from these plants and were shown to contain the two new dsRNA components, thus demonstrating the existence of a new beet cryptic virus, which we have called BCV3.  相似文献   

A NEW TECHNIQUE FOR SOIL PIT ILLUSTRATIONS     

L. P. WHITE 《European Journal of Soil Science》1972,23(1):58-61

The difficulty of illustrating soil pit detail can be overcome by using selected grey density slices of original photographs. The technique of density slicing for illustrations involves the separate printing of a particular shade of grey from the original, which picks out the detail required.  相似文献   

THE EXPERIMENTAL REPRODUCTION FO NASAL GRANULOMA BY REPEATED ACUTE EPISODES OF IMMEDIATE HYPERSENSITIVITY     

D. H. PEMBERTON B.V.Sc.    W. E. WHITE M.V.Sc.  Ph.D.  D. E. HORE B.v.Sc. Ph.D. 《Australian veterinary journal》1974,50(5):233-234

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The characteristics of agglutinating antigens of Vibrio fetus variants. I. Effects of heat and formalin on serological activity     

RISTIC M  WHITE FH  DOTY RB  HERZBERG M  SANDERS DA 《American journal of veterinary research》1957,18(69):764-770

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Planning,Participation, and Social Change     

CORALIE BRYANT  LOUISE G. WHITE 《Growth and change》1975,6(1):38-43

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Simultaneous nitrification and diffusion in soil. I. The effects of the addition of a low level of ammonium chloride     

P. R. DARRAH  R. E. WHITE  P. H. NYE 《European Journal of Soil Science》1985,36(2):281-292

The nitrification of NH₄⁺ and the simultaneous diffusion of NH₄⁺, NO₃^? and H⁺ following the addition of ammonium chloride to a fine sandy loam soil was analysed experimentally and theoretically. Experimentally, the concentration profiles of mineral N and pH were analysed 140h and 284 h after the homogeneous addition of 11 μmoles NH₄Cl_cm^?3 of soil to one part of a composite soil column. The mathematical model presented includes a kinetic model of nitrifier growth and activity, the adsorption equilibria of NH₄⁺ and soil acidity with the soil solid phase and the influence of other ions on the diffusion characteristics of each diffusing ion. The predictions of the model were generated using parameters derived from independent experiments so that the predictions did not depend on data derived from the experimental concentration profiles. Good agreement was found between experimental and predicted profiles. The use of the model for predicting the penetration of NH₄⁺ and NO₃^? into the soil is demonstrated.  相似文献   

Simultaneous nitrification and diffusion in soil. III. The effects of the addition of ammonium sulphate     

P. R. DARRAH  P. H. NYE  R. E. WHITE 《European Journal of Soil Science》1986,37(1):53-58

The simultaneous nitrification and diffusion of NH₄⁺, applied as ammonium sulphate to laboratory columns, was followed experimentally and with a simulation model. Ammonium was applied as a fertilizer band at levels equivalent to 69 kg N ha^?1 to a 1 cm depth. The concentration profiles of NH₄⁺, NO₃^?, SO^2?₄ and pH were measured in two columns for incubation times of 214 and 286 h. The simulation model provided for the precipitation and ion pair formation of CaSO₄, the adsorption equilibria of NH₄⁺ and soil acid with the soil solid phase, and nitrifier growth and activity. In general, good agreement was found between the experimental and simulated concentration profiles. The effect of CaSO₄ precipitation on the diffusion of N was investigated using model simulations of the diffusion of NH₄⁺ in the absence of nitrification. The simulations suggested that the reactions of SO^2?4 in the soil could markedly affect the spread of NH₄⁺ from a band of (NH₄)₂SO₄.  相似文献   

Simultaneous nitrification and diffusion in soil   总被引：2，自引：0，他引：2  

P. R. DARRAH  P. H. NYE  R. E. WHITE 《European Journal of Soil Science》1986,37(3):479-484

Darrah et al. (1985b, 1986) presented a model that predicted the distribution of ammonium and nitrate in a column of soil, following the addition of ammonium chloride as a band of fertilizer to one end of the column. Ammonification and nitrification, the inhibition of nitrification by high levels of fertilizer addition and the simultaneous diffusion of ammonium and nitrate were modelled. By simplifying algorithms concerned with the calculation of the concentration of ammonium in solution and the diffusion of solutes in the column, up to eight-fold savings in the time required to run the model could be made without significantly affecting the accuracy of the predictions. This simplified version was used to test the effect of a ±25% change in the values of the main input parameters. The distribution of ammonium was mainly influenced by parameters affecting the diffusive flux of solutes and the concentration of ammonium in the soil solution; that of nitrate was influenced by parameters affecting the growth, activity and inhibition of the nitrifiers. In general, the model was most sensitive to changes in the maximum specific growth rate of the nitrifiers, while almost no effect was observed when the affinity constant for ammonium oxidation was varied. Given the present state of knowledge of the range of parameter values in different soils, it is necessary to measure all the input parameters tested, with the possible exception of the diffusional impedance factor, in order to obtain accurate predictions from the model.  相似文献