Lupus-Type "Anticoagulant" in a Dog With Hemolysis and Thrombosis   总被引：1，自引：1，他引：0  

Michael S. Stone  Ian B. Johnstone  Marjory Brooks  Trent K. Bollinger  Susan M. Cotter 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(1):57-61

A circulating anticoagulant was detected in a 2-year-old Chesapeake Bay Retriever with hemolytic anemia, nephrotic syndrome, thrombocytopenia, polyarthropathy, and pulmonary thromboembolism. A persistent prolongation of the activated partial thromboplastin time (aPTT) was detected, and it did not correct with repeated administration of fresh frozen plasma. The aPTT was still prolonged, with a 1:1 mixture of patient's plasma and normal dog plasma in vitro, suggesting the presence of a circulating inhibitor. Results of assays to characterize the inhibitor were compatible with those described for the lupus anticoagulant in human patients with systemic lupus erythematosus. Paradoxically, patients having the lupus anticoagulant are at increased risk for thrombosis. Pulmonary thromboembolism has been described as a frequent complication of immune-mediated hemolytic anemia in the dog, and the presence of a circulating anticoagulant should be considered as a potential mechanism.  相似文献   

Factor VIII Deficiency in a Cat          下载免费PDF全文

Johnstone IB  Morton JC  Allen DG 《The Canadian veterinary journal. La revue veterinaire canadienne》1987,28(10):671-673

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Corneal sequestrum in the cat. Repair using a tarso-conjunctival pedicle flap     

Irving AC  Johnstone AC 《New Zealand veterinary journal》1988,36(2):73-76

Corneal sequestrum was diagnosed upon clinical examination of 12 cats. The cornea of seven were examined histologically and had focal necrosis and inflammation of the stroma and epithelium. As the simple excision of the corneal lesions had been unsuccessful in two of the cats, repair of these was effected by construction of a tarso-conjunctival pedicle flap after the excision of the sequestrum.  相似文献   

Submitting canine blood for prothrombin time and partial thromboplastin time determinations   总被引：2，自引：1，他引：1  

Smalko D  Johnstone IB  Crane S 《The Canadian veterinary journal. La revue veterinaire canadienne》1985,26(4):135-136,137

Practitioners commonly submit samples from dogs for partial thromboplastin time and prothrombin time determinations. Controversy exists as to the necessity for rapid separation of plasma and cells, and submission of the plasma on ice (or frozen). The purpose of this study was to address three questions. First, is it better to submit plasma or is whole blood satisfactory? Second, is it necessary to refrigerate the sample or is maintenance at room temperature (20° C) adequate? Third, does the sample have to arrive at the laboratory within a few hours of collection or can reliable partial thromboplastin time/prothrombin time determinations be made on samples up to 48 hours old?It has been shown by this study that reliable partial thromboplastin time and prothrombin time determinations can be carried out on canine plasma for up to 48 hours after collection regardless of whether or not the plasma is separated immediately; however the samples must be kept at 4°C. If the samples are maintained at room temperature, reliable prothrombin time determinations can be obtained for up to six hours after collection regardless of whether or not the plasma is separated immediately. Reliable partial thromboplastin time determinations can be made on plasma stored at 20°C for up to 24 hours after collection and possibly longer (up to 48 hours) if the plasma has been separated immediately.  相似文献   

Small intestinal carcinoma in cattle     

Johnstone AC  Alley MR  Jolly RD 《New Zealand veterinary journal》1983,31(9):147-149

The pathology of carcinoma of the small intestine in six adult cattle is described. The lesions were similar to those of carcinoma of the small intestine of sheep although a slightly less fibrous stroma and a greater tendency to metastasise was observed. Initial findings suggest the disease resembles small-intestinal carcinoma of sheep and cola-rectal carcinomas of man in having a higher prevalence in New Zealand than most other countries. This highlights the need to investigate common environmental factors which may be responsible for the induction and promotion of these tumours in both grazing ruminants and man.  相似文献   

Type III von Willebrand's disease in Scottish terriers: A report of two cases          下载免费PDF全文

Johnstone IB  Norris AM  Hirzer L 《The Canadian veterinary journal. La revue veterinaire canadienne》1993,34(11):679-681

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A pathological and microbiological evaluation of omphalophlebitis in very young calves slaughtered in New Zealand     

Hathaway SC  Bullians JA  Johnstone AC  Biss ME  Thompson A 《New Zealand veterinary journal》1993,41(4):166-170

Omphalophlebitis, generally referred to as navel ill, is a common post-mortem meat inspection finding in very young calves slaughtered in New Zealand, and a gross pathological, histopathological and bacteriological evaluation of 147 carcasses condemned for this condition at routine post-mortem meat inspection was undertaken. Localised lesions restricted to the umbilicus alone were present in 29.9% of cases. The majority of cases included gross pathological change in the umbilical vessels and other tissue sites beyond the umbilicus. Most hepatic nodes were grossly normal but histological examination revealed that 61.5% of nodes from other than localised cases of navel ill were hyperplastic. However, there was little difference in the prevalence of hyperplastic hepatic nodes from cases of localised navel ill (21.4%) compared with normal calves (15.9%). Despite the wide range of bacteria isolated from umbilical lesions, Salmonella typhimurium recovered from the navel, liver and hepatic nodes of a single extended case of navel ill was the only isolation of known public health importance. Given the separation of cases of navel ill into different gross pathological, histopathological and microbiological categories, current meat inspection judgments whereby all calves with navel ill are condemned should be revised. In particular, routine condemnation of the carcass and viscera in all cases of localised navel ill (lesions restricted to the umbilicus alone) should be reassessed.  相似文献   

Observations on hypoglycaemia associated with a hepatoma in a cat     

Thompson JC  Hickson PC  Johnstone AC  Jones BR 《New Zealand veterinary journal》1995,43(5):186-189

Disorientation, muscle fasciculations and weakness seen in a 12-year-old neutered female domestic shorthaired cat were attributed to hypoglycaemia associated with a large hepatoma. Glucagon tolerance tests on this cat and a healthy cat showed that their plasma glucose concentrations increased and decreased at about the same rate. Plasma insulin concentrations in the healthy cat increased and decreased in parallel with the plasma glucose concentration. In the affected cat, plasma insulin concentrations increased initially but decreased more rapidly. Reflecting these observations, the amended insulin to glucose ratios in the affected cat were much lower than those of the healthy cat, until the 4-hour sample. Serum somatostatin, somatomedin and gastrin concentrations were measured but no conclusions as to pathogenesis of the hypoglycaemia could be made. The alterations in insulin secretion in the affected cat suggested that altered hormonal control of glucose homeostasis may have occurred with this tumour.  相似文献   

Lymphoid leukaemia in a cow     

Johnstone AC 《New Zealand veterinary journal》1982,30(10):145-146

An 18-month old Friesian heifer which had lost condition and had diarrhoea for several weeks was diagnosed by haematological and pathological examinations as having lymphocytic leukaemia. True lymphatic leukaemia has not previously been described in cattle and does not readily fit into presently accepted classifications of bovine leukosis.  相似文献   

Actinobacillosis in an alpaca (Lama pacos)     

Hill FI  Johnstone AC 《New Zealand veterinary journal》1992,40(1):28-30

The death of a 6-week-old alpaca being treated for acute polyarthritis is described. Post-mortem and histological findings included fibrinous mural endocarditis, lung abscessation, acute passive congestion of the liver, embolic suppurative nephritis and chronic nonsuppurative polyarthritis. Actinobacillus suis was isolated from the heart lesion and in pharyngeal swabs from four of six clinically normal alpacas in the same flock.  相似文献