A Preliminary Trial of Detomidine/Opiate Combination in the Horse     

B.S. Paton  K.W. Clarke 《Veterinary anaesthesia and analgesia》1986,14(1):44-52

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Sedative and cardiovascular effects of romifidine, alone and in combination with butorphanol, in the horse   总被引：1，自引：1，他引：0  

K. W. Clarke  G. C. W. England  L. Goossens 《Veterinary anaesthesia and analgesia》1991,18(1):25-29

The behavioural and sedative effects of intravenous (iv) romifidine (40 and 80 μg/kg bodyweight [bwt]) alone or in combination with iv butorphanol (50 μg/kg bwt) were investigated in four ponies and one Thoroughbred horse. Apparent sedation, as judged by the lowering of the head, and by the response to imposed touch, visual and sound stimuli was assessed. The combination with butorphanol reduced the animals' response to imposed stimuli when compared with the effect of the same dose of romifidine alone. Following the administration of romifidine/butorphanol combinations muzzle tremor was noted and some animals attempted to walk forward. In a separate series, the cardiopulmonary effects of iv romifidine (80 μg/kg bwt) alone, or in combination with butorphanol (50 μg/kg bwt) were investigated. Romifidine and the romifidine/butorphanol combination caused similar cardiovascular changes, these being bradycardia with heart block, and hypertension followed by hypotension. Romifidine caused a transient decrease in arterial oxygen tensions and arterial carbon dioxide tensions had increased significantly by the end of the 90 min recording period. Romifidine/butorphanol combinations produced significantly higher arterial carbon dioxide tensions during the first 15 mins after drug administration than did romifidine alone. Butorphanol at 50 μg/kg bwt iv reduced the response to imposed stimuli in horses sedated with romifidine. The combination produced no cardiovascular changes beyond those induced by romifidine alone, but did increase the degree of respiratory depression.  相似文献   

Fertilization and early embryo development in the potato     

Alfred E. Clarke 《American Journal of Potato Research》1940,17(1):20-25

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Paratuberculosis and molecular biology     

C.J. Clarke 《Veterinary journal (London, England : 1997)》1997,153(3):245-247

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Enteric pathogens and the food chain          下载免费PDF全文

Clarke RC 《The Canadian veterinary journal. La revue veterinaire canadienne》1987,28(5):270-272

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Pathophysiologic mechanism of cardiac dysfunction in experimentally induced heartworm caval syndrome in dogs: an echocardiographic study     

C E Atkins  B W Keene  S M McGuirk 《American journal of veterinary research》1988,49(3):403-410

In dogs with experimentally induced heartworm infection, the onset of caval syndrome (CS) was characterized by a murmur, loudest over the tricuspid valve, and a large worm mass in the right ventricular lumen detectable during diastole by use of M-mode echocardiography. Two-dimensional echocardiography indicated that the worm mass was located in the right atrium and venae cavae and was "flowing" into the right ventricle during rapid diastolic filling. Paradoxical septal motion and vigorous right ventricular cranial wall motion also were observed. Other echocardiographic changes included decreased size of the left atrium and ventricle, aortic root, and ratio of left-to-right ventricular diastolic luminal diameter, compared with values obtained 6 months after experimentally induced heartworm infection. Right ventricular end diastolic diameter increased considerably. Most echocardiographic indices of left ventricular function (fractional shortening, velocity of circumferential fiber shortening, ejection fraction, and preejection period) were not altered appreciably, but estimates of cardiac index and stroke volume were markedly decreased. Electrocardiography revealed ventricular and supraventricular premature complexes in 7 of the 8 dogs studied, evidence of right ventricular enlargement in 6 of the 8 dogs studied, and increased mean heart rate, compared with that measured 6 months after inoculation of infective larvae, before the onset of CS. Cardiac catheterization was performed in 3 days at the onset of CS. Severe pulmonary arterial and right ventricular hypertension and decreased cardiac index (compared with values obtained before inoculation) were observed. Evidence of right ventricular inflow obstruction was not detected. Mean aortic blood pressure decreased with the onset of CS, but right ventricular end diastolic pressure increased.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Insulin treatment and development of anti-insulin antibodies in a horse with diabetes mellitus associated with a functional pituitary adenoma          下载免费PDF全文

Staempfli HR  Eigenmann EJ  Clarke LM 《The Canadian veterinary journal. La revue veterinaire canadienne》1988,29(11):934-936

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An in vitro study of the replication of Mycoplasma ovipneumoniae.     

R M Major  J K Clarke  M R Alley 《New Zealand veterinary journal》1979,27(4):58-61

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Parasites of Chamois in New Zealand     

Clark WC  Clarke CM 《New Zealand veterinary journal》1981,29(8):144

Abstract Sir, - Andrews'((2)) checklist of helminth parasites of wild ruminants in New Zealand recorded the presence of 10 species of gastrointestinal nematodes in chamois (Rupicapra rupicapra rupicapra L.) from "Central South Island". In October 1978 we examined 28 freshly-shot chamois cadavers from the Harper-Avoca watershed in the headwaters of the Rakaia River. Six of the nematode species reported by Andrews were found again; viz. Ostertagia ostertagi, O. circumcincta, O. trifurcata, Nematodirus filicollis, Oesophagostomum venulosum and Trichuris ovis. The 4 species found by Andrews that were not recovered by us from the animals we examined were: Trichostrongylus axei, T. vitrinus, Spiculotragia spiculoptera and S. asymmetrica. On the other hand we found 4 helminths not encountered by Andrews: 3 nematodes: Nematodirus spathiger (Railliet, 1896), N. abnormalis (May, 1920), and Chabertia ovina (Fabricius, 1794), and 7 specimens of the cestode Moniezia expansa (Rud., 1805). Nematodirus spathiger was the most commonly encountered Nematodirus species, but generally the numbers of all 3 species encountered were low as might be expected in a sample of adult and almost year-old animals. It is probable that most of the adults had acquired some measure of immunity((3)), and the most susceptible group, the kids, would not be born until late November. Because peptic digestion was not used to recover juveniles from the intestinal submucosa, only small numbers of adults were obtained.  相似文献   

Feline ureteral obstructions Part 1: medical management          下载免费PDF全文

D. L. Clarke 《The Journal of small animal practice》2018,59(6):324-333

Feline ureteral obstructions are an increasingly recognised and challenging diagnostic and management problem. Many cats with ureteral obstructions are critically ill at the time of diagnosis, especially if there is dysfunction of the contralateral kidney. They may present with varying severities of acute kidney injury, electrolyte disturbances, and may have comorbidities such as heart disease that complicate perioperative and long‐term management. Medical management, which may consist of rehydration and restoration of intravascular volume with intravenous fluid therapy, osmotic diuresis, ureteral muscle relaxation, and antimicrobials for infection, is important in feline ureteral obstruction patients. Despite medical management, many cats with ureteral obstructions will require decompression of the obstructed kidney to relieve pressure‐nephropathy and restore urine flow. However, some cats may be too unstable for traditional medical management and require more emergent intervention to relieve the obstruction and address the life‐threatening sequelae to acute kidney injury, such as hyperkalaemia and fluid overload. Both surgical and interventional methods to address ureteral obstructions have been described in veterinary medicine, though debate continues as to the ideal approach.  相似文献