2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs          下载免费PDF全文

M. Podell  H.A. Volk  M. Berendt  W. Löscher  K. Muñana  E.E. Patterson  S.R. Platt 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2016,30(2):477-490

This report represents a scientific and working clinical consensus statement on seizure management in dogs based on current literature and clinical expertise. The goal was to establish guidelines for a predetermined, concise, and logical sequential approach to chronic seizure management starting with seizure identification and diagnosis (not included in this report), reviewing decision‐making, treatment strategies, focusing on issues related to chronic antiepileptic drug treatment response and monitoring, and guidelines to enhance patient response and quality of life. Ultimately, we hope to provide a foundation for ongoing and future clinical epilepsy research in veterinary medicine.  相似文献   

Safety and immunologic effects after inoculation of inactivated and combined live-inactivated dermatophytosis vaccines in cats     

DeBoer DJ  Moriello KA  Blum JL  Volk LM  Bredahl LK 《American journal of veterinary research》2002,63(11):1532-1537

OBJECTIVE: To determine antidermatophyte immunologic effects of an experimental combined live-inactivated dermatophytosis vaccine (CLIDV) and a commercial inactivated dermatophytosis vaccine (IDV) in cats and to evaluate adverse effects associated with administration of these vaccines. ANIMALS: 20 healthy juvenile domestic shorthair cats. PROCEDURE: Cats were injected with 2 doses of CLIDV at the standard dosage or 1 dose of CLIDV at 10 times the standard dosage; IDV was administered at the manufacturer-recommended dosage. Cats were observed for illness and reactions at inoculation sites. Periodically, samples were obtained for fungal culture, lymphocyte blastogenesis test (LBT) as an indicator of cell-mediated immunity against dermatophyte antigens, and antidermatophyte IgG titers. Following vaccination, cats were challenge-exposed by topical application of Microsporum canis macroconidia and examined weekly for clinical signs of dermatophytosis. RESULTS: of 10 cats given CLIDV developed focal crusts at the injection site that resolved without treatment; these were areas of dermatophyte infection with the vaccine strain. Antidermatophyte IgG titers increased significantly with all vaccination protocols. Cellular immunity against M canis increased slightly and variably during the vaccination period and did not differ significantly between vaccinated and control cats. All cats developed dermatophyte infection after challenge exposure. Vaccination with CLIDV or IDV was associated with slightly reduced severity of initial infection. CONCLUSIONS AND CLINICAL RELEVANCE: Noculation with IDV or CLIDV did not provide prophylactic immunity against topical challenge exposure with M canis. Inoculation with either vaccine did not provide a more rapid cure of an established infection.  相似文献   

Application of the Soil and Water Assessment Tool (SWAT) to predict the impact of alternative management practices on water quality and quantity   总被引：10，自引：0，他引：10  

Antje Ullrich  Martin Volk 《Agricultural Water Management》2009,96(8):1207-1217

Alternative land management practices such as conservation or no-tillage, contour farming, terraces, and buffer strips are increasingly used to reduce nonpoint source and water pollution resulting from agricultural activities. Models are useful tools to investigate effects of such management practice alternatives on the watershed level. However, there is a lack of knowledge about the sensitivity of such models to parameters used to represent these conservation practices. Knowledge about the sensitivity to these parameters would help models better simulate the effects of land management. Hence, this paper presents in the first step a sensitivity analysis for conservation management parameters (specifically tillage depth, mechanical soil mixing efficiency, biological soil mixing efficiency, curve number, Manning's roughness coefficient for overland flow, USLE support practice factor, and filter strip width) in the Soil and Water Assessment Tool (SWAT). With this analysis we aimed to improve model parameterisation and calibration efficiency. In contrast to less sensitive parameters such as tillage depth and mixing efficiency we parameterised sensitive parameters such as curve number values in detail.In the second step the analysis consisted of varying management practices (conventional tillage, conservation tillage, and no-tillage) for different crops (spring barley, winter barley, and sugar beet) and varying operation dates. Results showed that the model is very sensitive to applied crop rotations and in some cases even to small variations of management practices. But the different settings do not have the same sensitivity. Duration of vegetation period and soil cover over time was most sensitive followed by soil cover characteristics of applied crops.  相似文献   

Zur Natürlichkeit der Esche (Fraxinus excelsior L.) in Flussauen Mitteleuropas     

Helmut Volk 《European Journal of Forest Research》2002,121(3):128-137

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Corpus Callosal Abnormalities in Dogs     

R. Gonalves  H. Volk  P.M. Smith  J. Penderis  L. Garosi  E. MacKillop  A. de Stefani  G. Cherubini  J.F. McConnell 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(4):1275-1279

Background

Corpus callosal abnormalities (CCA) in dogs have been only sporadically reported and are poorly characterized.

Hypothesis/Objectives

To describe the clinical presentation and magnetic resonance imaging (MRI) characteristics of dogs with CCA.

Animals

Fifteen client‐owned dogs.

Methods

Retrospective study. Records of the contributing institutions were reviewed to identify dogs diagnosed with malformations affecting the corpus callosum (CC); cases in which the CCA was thought to be secondary were excluded.

Results

The most represented breeds were Staffordshire Bull Terriers (5/15) and Miniature Schnauzers (3/15; n = 3, 20%) and the mean age at time of presentation of 19 months (range 3–81 months). The clinical signs most commonly reported were adipsia/hypodipsia with associated hypernatremia (12/15), tremors (6/15), and seizures (6/15). Review of the MR images revealed that 10 dogs had absence of the rostral CC and hypoplasia of the caudal portion, 4 dogs had a diffusely hypoplastic and dysplastic CC, and 1 dog had a diffusely hypoplastic CC. In 14 cases, there was abnormal cortical development with fusion of the ventral frontal lobes and part of the diencephalon, indicating lobar holoprosencephaly.

Conclusions and Clinical Importance

Previous literature has mainly associated CCA with adipsia and only 12 of 15 dogs in the current series demonstrated this abnormality. There are different degrees of the malformation but in 10 dogs the rostral portion of the CC is most severely affected. Fourteen dogs have simultaneous fusion of the midline structures rostral to the CC; this region has several structures involved in thirst regulation and might explain this derangement.  相似文献   

Diagnosis,treatment and outcome of spinal lymphoma in a pony     

E. J. T. Finding  T. Ciasca  M. J. Pinilla  C. J. Driver  I. C. Johns  R. Weller  H. A. Volk 《Equine Veterinary Education》2014,26(6):303-305

This report describes the diagnostic approach to, and treatment of, a case of severe pelvic limb ataxia in a Miniature Shetland pony. Diagnosis of an intradural‐extramedullary lesion at the level of T11–12 was made using CT myelography. Dorsolateral hemilaminectomy allowed surgical debulking of an intradural mass, diagnosed histopathologically as T cell rich B cell lymphoma. Post operative treatment with prednisolone, cytarabine and cyclophosphamide was tolerated well and the degree of ataxia reduced markedly, allowing the pony to return to normal management.  相似文献   

Chloramphenicol 3. Clinical pharmacology of systemic use in the horse     

SW PAGE 《Australian veterinary journal》1991,68(1):5-8

The use of chloramphenicol in the horse is now prohibited as horses are classified as food-producing animals. However, chloramphenicol has until recently been widely available for oral, intramuscular or intravenous administration. A critical appraisal of the published literature on the use of chloramphenicol in the horse clearly demonstrates that there are sound pharmacokinetic and microbiological reasons for concluding that chloramphenicol is not an appropriate antibiotic for systemic use. The short half-life of chloramphenicol in the horse, together with the broad range of minimum inhibitory concentrations of target pathogens, preclude the use of practical dosage regimens. It can be concluded that the withdrawal of chloramphenicol will have no adverse effects on chemotherapy in the horse.  相似文献   

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease     

Outeiro TF  Kontopoulos E  Altmann SM  Kufareva I  Strathearn KE  Amore AM  Volk CB  Maxwell MM  Rochet JC  McLean PJ  Young AB  Abagyan R  Feany MB  Hyman BT  Kazantsev AG 《Science (New York, N.Y.)》2007,317(5837):516-519

The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.  相似文献   

Cutaneous reaction after intravenous administration of medetomidine?     

Viscasillas J  Seymour C  Knudsen T  Levien A  Volk A 《Veterinary anaesthesia and analgesia》2011,38(4):413-414

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Middle ear effusions in dogs: an incidental finding?     

Volk HA  Davies ES 《Veterinary journal (London, England : 1997)》2011,188(3):256-257

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