THE CHESTNUT BLIGHT AND ITS RELATION TO THE PRINCIPLE OF DISEASE RESISTANCE     

Kelley AP 《Science (New York, N.Y.)》1940,91(2360):290-291

  相似文献   

Bovine sire effects on daughters' in vitro blood neutrophil functions, lymphocyte blastogenesis, serum complement and conglutinin levels     

M E Kehrli  K A Weigel  A E Freeman  J R Thurston  D H Kelley 《Veterinary immunology and immunopathology》1991,27(4):303-319

Blood neutrophil functions, lymphocyte blastogenic responses, serum complement, and serum conglutinin activity of 98 lactating Holstein cows from two genetic lines were evaluated. The genetic lines were produced in a selection experiment that created and perpetuated genetic differences in milk production for up to seven generations. No significant differences between the two genetic lines of cows were found for neutrophil function, lymphocyte blastogenic responses, serum complement levels, or serum conglutinin levels. Significant differences between sire progeny groups within lines were found for unstimulated and mitogen-stimulated lymphocyte blastogenesis (P less than 0.0001), and almost all neutrophil functions (antibody independent neutrophil cytotoxicity, antibody dependent neutrophil cytotoxicity, ingestion of bacteria, iodination, chemiluminescence, chemokinesis, and chemotaxis (P less than or equal to 0.05)). Sire progeny group differences (P less than or equal to 0.0001) within lines for serum complement and conglutinin activity were also found. Neutrophil chemiluminescence activity (positive relationship; P less than or equal to 0.001), concanavalin A-stimulated lymphocyte blastogenesis (positive relationship; P less than or equal to 0.004), and serum conglutinin activity levels (negative relationship; P less than or equal to 0.01) each had small but significant associations with the total milk somatic cell count. Cows seropositive for bovine leukosis virus had increased resting and mitogen-stimulated lymphocyte blastogenic activity and were associated with increased in vitro neutrophil random migration and production of superoxide anion. Estimates of genetic parameters of various immune cell functions, of serum complement and of conglutinin levels for daughters of 11 sires with 4-6 daughters in the data set were determined. In this report, genetic variation was demonstrated for nonspecific humoral and cellular immunity.  相似文献   

A revealing tool     

Kelley SA 《Science (New York, N.Y.)》1993,260(5112):1357-1358

  相似文献   

Comparative,multidimensional imaging of patent ductus arteriosus and a proposed update to the morphology classification system for dogs          下载免费PDF全文

Kelley R. Doocy  Ashley B. Saunders  Sonya G. Gordon  Nicholas Jeffery 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(2):648-657

  相似文献   

Removal of hemangiosarcoma cells from canine blood with a cell salvage system and leukocyte reduction filter          下载免费PDF全文

Brittany Ciepluch DVM  MS  Heather Wilson‐Robles DVM  DACVIM  Gwendolyn Levine DVM  DACVP  Roger Smith DVM  PhD  Gus A. Wright PhD  Tasha Miller BS  Maureen T. O'Brien DVM  MS  DACVP  Kelley M. Thieman Mankin DVM  MS  DACVS‐SA 《Veterinary surgery : VS》2018,47(2):293-301

  相似文献   

The impact of postdischarge surveillance on surgical site infection diagnosis          下载免费PDF全文

Danielle N. Garcia Stickney DVM  Kelley M. Thieman Mankin DVM  MS  DACVS‐SA 《Veterinary surgery : VS》2018,47(1):66-73

  相似文献   

Evaluation of mechlorethamine,vinblastine, procarbazine,and prednisone for the treatment of resistant multicentric canine lymphoma     

Kelley Zimmerman  Koranda A. Walsh  Jonathan T. Ferrari  Nicholas S. Keuler  Matthew J. Atherton  Jennifer A. Lenz 《Veterinary and comparative oncology》2023,21(3):503-508

Multi-agent chemotherapy successfully induces remission in most naïve, high-grade canine lymphoma patients; however, disease recurrence is common. MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) is an effective rescue protocol used to re-induce remission, but is associated with gastrointestinal toxicity and can be a less desirable option for patients that previously failed vincristine-containing protocols. Therefore, alternative members of the vinca alkaloid family, such as vinblastine, could be potentially advantageous as substitutes for vincristine to reduce gastrointestinal toxicity and chemoresistance. The objective of this study was to report the clinical outcomes and toxicity of 36 dogs with relapsed or refractory multicentric lymphoma treated with a modified MOPP protocol whereby vincristine was replaced with vinblastine (MVPP). The overall response rate to MVPP was 25% with a median progression free survival of 15 days and a median overall survival of 45 days. MVPP at the prescribed doses resulted in modest and transient clinical benefit, but was well tolerated with no treatment delays or hospitalizations secondary to side effects. Given the minimal toxicity, dose intensification could be considered to improve clinical responses.  相似文献   

Congenital arthrogryposis: an inherited limb deformity in pedigree Suffolk lambs     

Doherty ML  Kelley EP  Healy AM  Callanan JJ  Crosby TF  Skelly C  Boland MP 《The Veterinary record》2000,146(26):748-753

Thirty of 52 pedigree Suffolk lambs (58 per cent) were born with arthrogryposis characterised by bilateral flexion rigidity of the metacarpophalangeal and carpal joints. The recent introduction of a breeding ram was identified as the only significant risk factor in the flock, and embryo transfer was used to test the hypothesis that the arthrogryposis was an inherited disorder associated with the introduction of this ram. Two adult ewes that had previously produced lambs with arthrogryposis by the ram and four of its affected daughters were available as donors, and 20 crossbred ewes were used as recipients. Ten Suffolk-crossed ewes that had no known familial relationship with the ram were also mated by the ram as controls and they produced 10 normal lambs. Following embryo transfer, 19 lambs were born, of which seven were stillborn; arthrogryposis was evident in 10 of the 12 live lambs. Analysis of the data suggested that in the population under study, arthrogryposis was inherited as an autosomal recessive condition.  相似文献   

Comparison of Outcome After Use of Extra‐Luminal Rings and Intra‐Luminal Stents for Treatment of Tracheal Collapse in Dogs          下载免费PDF全文

Selena Tinga DVM  Kelley M. Thieman Mankin DVM  MS  Diplomate ACVS  Laura E. Peycke DVM  MS  Diplomate ACVS  Noah D. Cohen VMD  MPH  PhD  Diplomate ACVIM 《Veterinary surgery : VS》2015,44(7):858-865

  相似文献   

Rhabdomyosarcoma associated with the lead wire of a pacemaker generator implant     

Kelley M. Thieman Mankin  Mark D. Dunbar  David Toplon  Pamela Ginn  Herbert W. Maisenbacher  Marije Risselada 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2014,43(2):276-280

An 11‐year‐old female spayed Labrador Retriever was presented for a draining, painful subcutaneous mass palpated over a previously implanted pacemaker generator. Infection was suspected and the mass was removed surgically. On cut surface, the mass was friable and mottled tan to brown with firm pale tan nodules, surrounding the pacemaker lead wire adjacent to the pacemaker generator. Cytologic interpretation of impression smears was consistent with a sarcoma, and suggestive of a rhabdomyosarcoma due to the presence of strap‐like cells. On histopathologic examination, a highly invasive nodular mass surrounded the pacemaker lead, composed of pleomorphic round, spindle and strap cells, and multinucleated giant cells. The population exhibited microscopic invasion into the deep portion of the fibrous capsule surrounding the pacemaker generator. There were tumor emboli within small to medium subcutaneous veins adjacent to the mass. Immunohistochemically, the neoplastic cells stained positive for α‐sarcomeric actin and vimentin, and negative for α‐smooth muscle actin, consistent with a rhabdomyosarcoma arising at the site of the pacemaker generator. To our knowledge, this is the first report of a rhabdomyosarcoma associated with the lead wire of a pacemaker generator in a dog.  相似文献