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纤维素硫酸钠(Na-CS)具有突出的抗凝血活性,为了研究相对分子质量(Mw)与其抗凝血活性的构效关系,需要制备具有不同Mw。硫酸酯取代度相同的Na-CS系列类似物。本实验通过酸水解和凝胶过滤一离子交换联合分离的方法获得不同Mw。的Na-CS样品,以此为研究对象,考察了Na-CS的Mw。对其抗凝血效果和对凝血因子抑制作用的影响规律。结果表明,在一定范围内,随着Mw增大,Na-CS对活化部分凝血活酶时间(APPT)和凝血酶时间(TT)的延长作用增强,对凝血因子Ⅱa和Xa的抑制作用提高。 相似文献
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水蛭药理作用的研究进展 总被引：3，自引：0，他引：3
水蛭是一味传统的中药,具有多种药理作用。随着技术的发展、研究的日益深入,水蛭越来越广泛的应用于临床,有着良好的医学应用前景。文章综述了水蛭的药理作用的研究进展。 相似文献
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Kelly A. Gavin Chick Weisse Allyson C. Berent 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2022,36(2):441
BackgroundAortic and aortoiliac thrombosis in dogs causes disease and death.ObjectiveTo describe the procedure and outcomes for stenting the caudal aorta and aortoiliac trifurcation.AnimalsSeven client‐owned dogs that underwent aortic/aortoiliac stenting for treatment of thrombosis.MethodsRetrospective multi‐center investigation. Medical records were reviewed for dogs that underwent stenting of the aorta or aortoiliac trifurcation between 2008 and 2020. Information collected included history, signalment, clinicopathologic data, diagnostic imaging, procedure reports, and outcomes.ResultsSeven dogs with an occlusive thrombus located at or near the aortic trifurcation were included. Four of 7 dogs were non‐ambulatory. Hind limbs were paretic in 5 dogs, paralyzed in 1 dog, and claudication alone was noted in 1 dog. Five of the 7 dogs had protein‐losing nephropathy (PLN). Of 5 dogs with PLN, 1 had protein‐losing enteropathy (PLE) and controlled hypothyroidism and 1 had caudal aortic chondrosarcoma. Two dogs had no identified underlying disease. Angiography was performed before catheter directed thrombolysis and stent placement. No deaths occurred during the procedure. Postoperative complications included pain (4/7), bruising and edema (3/7), bruising only (1/7), and edema only (1/7). Median survival time (MST) of the 7 dogs was 264 days (range, 1‐1053 days). Five of 7 dogs were ambulatory within 2 days of stenting and survived to discharge with a MST of 425 days (range, 208‐1053 days).Conclusions and Clinical ImportanceStenting of the aorta and aortoiliac trifurcation can provide an apparently safe and effective treatment with rapid return to ambulation for some dogs with aortic thrombosis. 相似文献
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袁春营。崔青曼。许江鹭。李广靖 《广东农业科学》2013,40(3):173-175
为进一步挖掘泥螺的药用价值,进行了泥螺糖胺聚糖光谱分析与生物学功能研究.分别采用KBr压片法、邻二氮菲-Fe2+氧化法、邻苯三酚自氧化法、MTT法、体外试验法进行糖胺聚糖红外光谱分析、糖胺聚糖对羟基自由基的清除作用、对超氧阴离子自由基的清除作用、对HepG2细胞生长的抑制作用及抗凝血活性研究.结果表明,该糖胺聚糖中含有-OH(3 400 cm-1)、-COO-(1 639 cm-1)、-SO2(1421 cm-1)、C-O-C(糖环,1 023 cm-)等基团,这些均为糖胺聚糖的特征基团;糖胺聚糖具有较强的清除羟基自由基的能力,但作用弱于维生素C,具有很弱的清除超氧阴离子自由基的能力;糖胺聚糖对肝癌细胞系(HepG2细胞)有较强的抑制作用;体外试验证实糖胺聚糖可延长新西兰白兔的TF、PT、APTT,但与肝素相比活性明显低弱. 相似文献
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对微晶纤维素(MCC)进行硫酸酯化修饰,得到多种β-1,4-葡聚糖硫酸酯(GS),其硫酸取代度(Ds)在1.10～1.70范围内.选择Ds为1.70的GS用于结构分析和抗凝血活性研究.IR分析表明,MCC通过硫酸化反应引入了硫酸酯基,13C NMR揭示,硫酸酯化主要发生在C6,部分在C2,而C3位不发生硫酸酯化反应.凝血分析表明,0.2 mg/L的GS即可显著延长血浆的活化凝血活酶时间(tAPTT)和凝血酶时间(tTT),使血浆tAPTT延长两倍,所需GS的剂量为0.7 mg/L,低于活性为150 IU/mg的肝素,在一定质量浓度范围内,GS的体外抗凝血活性与肝素相当.显色分析揭示,GS的抗凝血机制主要在于通过抗凝血酶AT-Ⅲ的调节作用抑制凝血因子Ⅱa和Xa的活性. 相似文献
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Chitin and sepia ink hybrid hemostatic sponge (CTSH sponge), a new biomedical material, was extensively studied for its beneficial biological properties of hemostasis and stimulation of healing. However, studies examining the safety of CTSH sponge in the blood system are lacking. This experiment aimed to examine whether CTSH sponge has negative effect on blood systems of mice, which were treated with a dosage of CTSH sponge (135 mg/kg) through a laparotomy. CTSH sponge was implanted into the abdominal subcutaneous and a laparotomy was used for blood sampling from abdominal aortic. Several kinds of blood parameters were detected at different time points, which were reflected by coagulation parameters including thrombin time (TT), prothrombin time (PT), activated partial thromboplatin time (APTT), fibrinogen (FIB) and platelet factor 4 (PF4); anticoagulation parameter including antithrombin III (AT-III); fibrinolytic parameters including plasminogen (PLG), fibrin degradation product (FDP) and D-dimer; hemorheology parameters including blood viscosity (BV) and plasma viscosity (PV). Results showed that CTSH sponge has no significant effect on the blood parameters of mice. The data suggested that CTSH sponge can be applied in the field of biomedical materials and has potential possibility to be developed into clinical drugs of hemostatic agents. 相似文献
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Evaluation of nafamostat mesilate as an alternative anticoagulant during intermittent hemodialysis in healthy Beagle dogs 
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