Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs     

Susan W. Mbugua  Lasse A. Skoglund  Per Lkken 《Acta veterinaria Scandinavica》1989,30(1):27-35

Randomized placebo-controlled crossover studies were carried out in dogs to evaluate how two non-steroidal anti-inflammatory drugs (NSAID) might modulate an acute post-traumatic inflammatory reaction. Two "identical" surgical interventions were performed on the forelimbs of each animal with an interval of 28 days, to enable a paired comparison of the inflammatory signs and the wound/bone healing processes. At one operation 8 dogs received 300 mg phenylbutazone twice daily for 8 days starting on the day before surgery, and at the other operation matching placebo tablets were given. In a similar placebo-controlled trial another group of 8 dogs received 5 mg indomethacin twice daily. With phenylbutazone the post-operative swelling was not significantly reduced compared to placebo, but there was less pain and limping. With indomethacin the swelling was somewhat reduced, but there was no consistent difference to placebo in the pain and limping assessments. None of the drugs appeared to distinctly effect the wound or fracture healing, as evaluated by clinical inspection, comparison of radiographs and comparison of bone sections from the sites of surgery. It proved difficult to select an appropriate dosage of indomethacin due to its high potential to induce GI ulceration and bleeding in dogs. In this experimental surgical model with an acute inflammation, neither phenylbutazone nor indomethacin showed impressive anti-inflammatory or analgesic properties. In the same model paracetamol has proved to significantly and more efficiently, reduce both swelling and pain without any noticeable adverse effects, and appears to be a better alternative than the two presently tested NSAID.  相似文献   

黄羽肉鸡ACSL1基因多态性与腹脂性状的相关性研究     

郎倩倩  徐振强  张燕  张德祥 《中国畜牧杂志》2021,(3):79-83,90

长链酯酰辅酶A合成酶(ACSLs)是长链脂肪酸通过硫代酯化进而合成酰基辅酶A衍生物所必需的酶,也是脂肪酸代谢的第一步。哺乳动物ACSL家族由ACSL1、ACSL3、ACSL4、ACSL5和ACSL65个不同的成员组成,ACSL1是主要的异构体之一。为探讨黄羽肉鸡ACSL1基因作为腹脂性状分子标记的可行性,本实验采用PCR-直接测序技术对黄羽肉鸡ACSL1基因进行遗传多态性分析。结果显示:黄羽肉鸡ACSL1基因第17到第18外显子区域(1295 bp)SNPs位点较丰富,T32126C、C32013T、A31958G这3个位点的等位基因频率符合哈代-温伯格平衡,且A31958G突变位点、T32126C突变位点与腹脂重、腹脂率不相关,C32013T突变位点对鸡的腹脂重与腹脂率有显著影响,提示能够利用C32013T突变位点对黄羽肉鸡腹脂重进行分子标记辅助选择。  相似文献   

The palliative efficacy of modified Mohs paste for controlling canine and feline malignant skin wounds     

Yasuhiro Fukuyama  Tetsushi Tezuka  Atsushi Kawabata  Takuya Maruo 《The Veterinary quarterly》2016,36(3):176-182

In veterinary medicine, the management of malignant skin wounds is highly challenging. We conducted a study on seven case animals (four dogs and three cats) which presented with malignant skin wounds. All seven animals had signs and symptoms which were controlled following treatment with a modified Mohs paste. Upon obtaining informed consent from their owners, the animals requiring management of malignant wounds were enrolled in this study. The modified Mohs paste was prepared by mixing zinc chloride, zinc oxide starch powder, glycerin, and distilled water. The modified Mohs paste was topically applied to and left to remain on the malignant wounds for one hour, under controlled conditions. Once the paste was removed, the wounds were irrigated with a solution of sterile saline. At the first examination, the wounds of each animal were observed for signs of exudate, malodor, and bleeding. In every case, visible improvement was observed immediately after the modified Mohs paste treatment. Specifically, the size of the malignant wounds, and the number of times the dressing gauze required changing, significantly decreased (p < 0.05 and p < 0.01, respectively). The open malignant skin wounds caused by mammary gland tumors disappeared in two cases. The Mohs paste has been shown to be a viable option for the palliative treatment in canine and feline malignant skin wound management.  相似文献   

Osteopontin expression in healing wounds of horses and in human keloids          下载免费PDF全文

V. Miragliotta  A. Pirone  E. Donadio  F. Abramo  M. P. Ricciardi  C. L. Theoret 《Equine veterinary journal》2016,48(1):72-77

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Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horses     

Hoffman AM  Oura TJ  Riedelberger KJ  Mazan MR 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(1):184-192

BACKGROUND: Horses with recurrent airway obstruction (heaves) are described as exhibiting "increased abdominal effort," but it is unknown whether this translates to an effective contribution to ventilation. HYPOTHESIS: We hypothesized that heaves is characterized by asynchrony between rib cage and abdominal motions, and that the abdominal component is the major contributor to ventilation. ANIMALS: The rib cage versus abdominal motion in naturally occurring heaves (n = 15) was compared to controls at rest (n = 7) and during hyperpnea because of lobeline treatment, and the effects of histamine-induced bronchoconstriction in controls (n = 10). METHODS: Flow patterns, phase angle (theta) between the rib and abdominal compartments, abdominal (Vabd) contribution to tidal volume (VT), and lung mechanics were measured. RESULTS: Findings unique to the heaves group included the loss of biphasic expiratory flow, severely increased theta with the abdomen consistently lagging behind the rib cage, and a reduced contribution of the abdomen to ventilation. A subgroup of heaves (n = 5) with abdominal paradox showed a significant (P < .05) reduction in tidal volume, and increased respiratory rate. Bronchodilation reduced theta in heaves (P = .06), but theta remained significantly higher after bronchodilation than found in controls. CONCLUSIONS AND CLINICAL IMPORTANCE: We conclude that breathing pattern in horses with heaves is characterized by severe rib cage/abdominal asynchrony, with the rib cage motion in synchrony with flow, therefore dominating ventilation. In a subset of heaves, the abdominal compartment (diaphragm, abdominal muscles) was completely out of synchrony with flow ("abdominal paradox") despite the clinical appearance of "increased abdominal effort."  相似文献   

Investigations on the Wound Healing Potential of Tilapia Piscidin (TP)2-5 and TP2-6     

Chia-Wen Liu  Chu-Yi Hsieh  Jyh-Yih Chen 《Marine drugs》2022,20(3)

Wound healing is a highly orchestrated process involving many cell types, such as keratinocytes, fibroblasts and endothelial cells. This study aimed to evaluate the potential application of synthetic peptides derived from tilapia piscidin (TP)2, TP2-5 and TP2-6 in skin wound healing. The treatment of HaCaT keratinocytes with TP2-5 and TP2-6 did not cause cytotoxicity, but did enhance cell proliferation and migration, which could be attributed to the activation of epidermal growth factor receptor signaling. In CCD-966SK fibroblasts, although TP2-5 (31.25 μg/mL) and TP2-6 (125 μg/mL) showed cytotoxic effects, we observed the significant promotion of cell proliferation and migration at low concentrations. In addition, collagen I, collagen III, and keratinocyte growth factor were upregulated by the peptides. We further found that TP2-5 and TP2-6 showed pro-angiogenic properties, including the enhancement of human umbilical vein endothelial cell (HUVEC) migration and the promotion of neovascularization. In a murine model, wounds treated topically with TP2-5 and TP2-6 were reduced by day 2 post-injury and healed significantly faster than untreated wounds. Taken together, these findings demonstrate that both TP2-5 and TP2-6 have multifaceted effects when used as topical agents for accelerating wound healing.  相似文献   

调亏灌溉下滴灌玉米根冠生长与水分动态响应特征   总被引：3，自引：0，他引：3  

魏永霞  马瑛瑛  冯鼎瑞  熊建  张雨凤  张翼鹏 《农业机械学报》2017,48(7):180-188

以玉米为试验材料,在自动感应式遮雨棚下,采用测坑微区试验方法,研究黑龙江西部滴灌条件下调亏灌溉对作物根冠生长、干物质分配特征、根冠比、耗水特征及植株伤流量的影响。以土壤相对含水率(占田间持水率的百分数)为控制上下限,设置5个水分调亏处理,分别为苗期轻度(60%~70%FC)处理,苗期中度(50%~60%FC)处理,拔节期轻度(60%~70%FC)处理,拔节期中度(50%~60%FC)处理,苗期中度、拔节期轻度处理,另设全生育期保持适宜土壤水分(70%~80%FC)作为对照。试验结果表明,调亏灌溉不改变玉米根部和冠部生长的原有总趋势,也不改变冠部各器官生长的基本趋势,但是显著地增大了作物根冠比(R/S),复水后根、冠补偿生长效应明显,促进光合同化产物向生殖器官的运转与分配,增大了生育后期干物质向果穗的分配率。苗期中度处理和拔节期轻度处理的玉米,在调亏期间使根系维持较高的根质量,水分胁迫复水后根系活力明显提高,其伤流量表现出超补偿效应,在灌浆期仍保持较高的伤流量并且在生育后期仍保持有较高的根冠比(R/S),是协调玉米根冠生长关系的适宜水分调亏处理。  相似文献   

Marine Collagen: A Promising Biomaterial for Wound Healing,Skin Anti-Aging,and Bone Regeneration     

Sarah Geahchan  Parnian Baharlouei  Azizur Rahman 《Marine drugs》2022,20(1)

Marine organisms harbor numerous bioactive substances that can be utilized in the pharmaceutical and cosmetic industries. Scientific research on various applications of collagen extracted from these organisms has become increasingly prevalent. Marine collagen can be used as a biomaterial because it is water soluble, metabolically compatible, and highly accessible. Upon review of the literature, it is evident that marine collagen is a versatile compound capable of healing skin injuries of varying severity, as well as delaying the natural human aging process. From in vitro to in vivo experiments, collagen has demonstrated its ability to invoke keratinocyte and fibroblast migration as well as vascularization of the skin. Additionally, marine collagen and derivatives have proven beneficial and useful for both osteoporosis and osteoarthritis prevention and treatment. Other bone-related diseases may also be targeted by collagen, as it is capable of increasing bone mineral density, mineral deposition, and importantly, osteoblast maturation and proliferation. In this review, we demonstrate the advantages of marine collagen over land animal sources and the biomedical applications of marine collagen related to bone and skin damage. Finally, some limitations of marine collagen are briefly discussed.  相似文献   

红辣椒粉和植物油对肉用仔鸡生产性能及脂肪沉积的影响   总被引：1，自引：0，他引：1  

田河  肖振铎  秦贵信  魏峰 《吉林农业大学学报》1994,16(3):71-77

本试验用３６ｏ只２１日龄的艾维因商品代肉用仔鸡，按３×３全因子试验设计，测定了辣椒粉（０，０．３％，０．５％）和植物油（０，３％豆油，３％玉米油）对肉用仔鸡生产性能及脂肪沉积的影响．试验结果表明，饲料中添加８％的植物油（豆油或玉米油）可提高仔鸡增重９．０２％～９．３４％（Ｐ＜０．０５），单位增重耗料量降低５．３６％～７．２０％（Ｐ＜０．０５），同时使屠宰率和腹脂率明显增加．添加０．３％和０．５％的辣椒粉可使鸡的增重分别提高３．６０％和４．０３％（Ｐ＜０．０５），添加辣椒粉对提高饲料转化率也有作用，但效果不显著（Ｐ＞０．０５）．在添加植物油的情况下，辣椒粉具有抑制腹脂沉积的作用，对母鸡效果尢为明显（Ｐ＜０．０５）。  相似文献   

七彩山鸡腹脂与皮下脂肪、肌脂率、肝脂率的关系     

王安琪  魏明奎  朱桂玲 《信阳农业高等专科学校学报》1999,(3)

在相同的条件下,饲养80羽公七彩山鸡和120羽母七彩山鸡,并于10周龄屠宰测定其腹脂、腹脂率和颈部、胸部、腿部皮下脂肪重;用乙醚抽提法测定了腿肌、胸肌、肝脏的含脂率。结果表明：腹脂重、腹胀率与腿部、胸部、颈部皮下脂肪呈显著的正相关（P＜0．05或P＜0．01）;而腹脂重、腹胀率、皮下脂肪重与腿肌、胸肌含脂率的相关性不显著（P＞0.05）;而与肝脏含脂率表现为显著的正相关（P＜0.05或P＜0.01）。  相似文献