Idiopathic eosinophilic colitis lesions of the equine small (descending) colon          下载免费PDF全文

M. P. de Bont  A. J. Malbon  R. Blundell  D. C. Archer 《Equine Veterinary Education》2018,30(9):466-471

Five horses with a primary surgical lesion of the small (descending) colon were diagnosed with eosinophilic colitis based on visual and histopathological examination. These were evident as visibly striking, hyperaemic, focal lesions of the small colon, with serosal petechiation, oedema and marked thickening of the intestinal wall at the site. Areas of focal necrosis were also evident. The gross appearance of the lesions were considered to be sufficiently severe in all cases to merit resection, due to concerns about intestinal necrosis and septic peritonitis. An inability to fully exteriorise the affected portion of intestine to perform a resection and anastomosis necessitated intraoperative euthanasia of one horse. A total of three horses survived to hospital discharge. Eosinophilic colitis lesions are a rare cause of severe small colon disease, but should be considered in cases with similar visual characteristics.  相似文献   

乳酸链球菌素及大黄组方对子宫内膜炎大鼠结肠的影响     

贾知锋  敖日格乐  贺美玲  张欣  徐进  高思明  王纯洁 《中国农业大学学报》2018,23(10):80-87

为研究乳酸链球菌素(Nisin)及大黄组方对患子宫内膜炎大鼠生殖系统内分泌调控与结肠炎症因子的影响,进一步揭示子宫内膜炎与结肠之间的关系,构建子宫内膜炎模型,建模前后用ELISA试剂盒检测各组大鼠子宫中髓过氧化物酶(MPO)、催产素(OXT)和检测患子宫内膜炎大鼠结肠中白介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)以及结肠菌群的变化情况来确定治疗效果。结果表明:1)造模前后,空白对照组中MPO和OXT的浓度无显著性差异;造模24h,Nisin组、大黄组方中和高剂量组中MPO的浓度显著降低;大黄组方高剂量组和阳性对照组中OXT的浓度显著高于阴性对照组和空白对照组,阴性对照组显著降低;造模48h,阴性对照组中OXT的浓度显著降低,且显著低于其他各组;造模72h,阴性对照组中MPO显著升高,OXT的浓度显著降低,大黄组方高剂量组和阳性对照组可显著降低子宫中MPO的浓度和显著增加OXT的浓度。2)在结肠中,患子宫内膜炎大鼠在0~72h阶段,阴性对照组中IL-1β和TNF-α的浓度显著升高,大黄组方高剂量组、Nisin组及阳性对照组中IL-1β和TNF-α的浓度显著降低。3)Nisin及大黄组方高剂量组显著增加结肠中乳酸杆菌和双歧杆菌的数量,显著减少大肠杆菌和肠球菌的数量。研究发现Nisin和大黄组方高剂量组可降低子宫内膜炎大鼠子宫中MPO和OXT的浓度,患子宫内膜炎大鼠使结肠中IL-1β和TNF-α的浓度升高,Nisin、大黄组方高剂量组和阳性对照组可降低IL-1β和TNF-α的浓度,还可以调节结肠中菌群结构。  相似文献   

应用VITEK2全自动微生物鉴定系统检测养殖用水中的大肠杆菌     

陈雪华 《热带作物学报》2012,32(5):76-80

采用国家相关的检验养殖用水标准方法、API 20E微生物生化试验、VITEK2全自动微生物鉴定系统，对养殖用水样品进行了大肠杆菌的检测方法比较和鉴定。VITEK2鉴定系统自动打印的实验报告和API 20E微生物生化试验的判读比对结果显示：3个参试样品分别为阴沟肠杆菌、产气肠杆菌和大肠埃希菌，VITEK2与API 20E两种方法的鉴定结果符合率100%。从实验可知，利用VITEK2全自动微生物鉴定系统，对被污染的养殖用水中细菌源的鉴定速度快，方法简便，结果准确、实用。此方法也可用于各种污染环境及食品污染源的  相似文献   

结肠癌术后早期肠内营养治疗25例临床分析     

杨海松  杨劲松 《吉林林学院学报》2011,(6):686-688

目的探讨结肠癌患者术后早期（24 h内）应用肠内营养的效果.方法回顾分析吉林医药学院附属医院2008年1月—2008年12月25例结肠癌患者术后早期给予肠内营养支持的临床资料.结果本组病例术后无任何并发症,疗效满意.结论结肠癌患者术后早期应用肠内营养支持,平均住院时间缩短,治疗费用降低,患者术后恢复快,是安全有效的方法.  相似文献   

T-shaped malformation of the ventral colon in a Thoroughbred filly with colic     

GD Trope  CM Steel 《Australian veterinary journal》2010,88(8):322-325

A 4-month-old Thoroughbred filly presented for abdominal pain was diagnosed with a T-shaped malformation of the ventral colon at exploratory laparotomy. Following resection and anastomosis of the large colon, no further episodes of abdominal pain occurred during a 12-month follow-up. Acute dehiscence of the linea alba occurred as a complication of the initial laparotomy, but was successfully managed following additional surgical repair. T-shaped malformation of the ventral colon has not previously been reported and is considered a congenital malformation of mesocolon formation.  相似文献   

Time course of the incidence/multiplicity and histopathological features of murine colonic dysplasia,adenoma and adenocarcinoma induced by benzo[a]pyrene and dextran sulfate sodium     

Jiro Sonoda  Yuki Seki  Atsushi Hakura  Satoru Hosokawa 《Journal of toxicologic pathology》2015,28(2):109-120

Benzo[a]pyrene (BP) is mutagenic but noncarcinogenic in the murine colon. Recently, we reported rapid induction of colonic tumors by treatment of CD2F₁ mice with BP (125 mg/kg for 5 days) followed by a colitis inducer, dextran sulfate sodium (DSS) (4% in drinking water for 1 or 2 weeks). However, there are no reports on detailed time course and histopathological features of colonic proliferative lesions in this model. Here, we show the detailed time course of colonic dysplasia, adenoma and adenocarcinoma induced by treatment with BP, DSS, and a combination of the two (BP/DSS). In the colon of mice exposed to BP/DSS, 14.6 dysplastic foci per mouse were present one week after DSS treatment (week 4). The number of dysplastic foci decreased with time to 3.1 at week 9 and thereafter remained almost constant. At week 4, 1.5 adenocarcinomas were also observed, with a marked increase in numbers with time, reaching 29.3 at week 14. In contrast, the number of dysplastic foci induced by DSS alone showed a time course similar to that following BP/DSS treatment; however, only a few tumors appeared. Neither dysplastic foci nor neoplastic lesions were induced by BP only. In mice exposed to BP/DSS, β-catenin was demonstrated immunohistochemically in the nucleus and/or cytoplasm of the tumor cells, and this translocation from the cell membrane was evident in subsets of dysplastic foci. In dysplastic foci induced by DSS alone, β-catenin was absent in the nucleus/cytoplasm. These finding suggest that aberrant β-catenin accumulation in dysplastic foci is associated with tumor progression in this BP/DSS model.  相似文献   

Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis     

Yu TAMURA  Hiroshi OHTA  Nozomu YOKOYAMA  Sue Yee LIM  Tatsuyuki OSUGA  Keitaro MORISHITA  Kensuke NAKAMURA  Masahiro YAMASAKI  Mitsuyoshi TAKIGUCHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(10):1407-1410

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Extensive umbilical herniation of the large colon in a foal     

C. J. Bodaan  L. Panizzi  A. J. Stewart  E. Cypher  L. Whitfield  C. B. Riley 《Equine Veterinary Education》2014,26(7):341-344

A 5‐month‐old Warmblood cross colt was presented with focal swelling of the ventral abdomen extending from the umbilicus to the scrotum in the absence of colic signs. Palpation and ultrasound examination revealed the presence of incarcerated large intestine within the subcutaneous space adjacent to the caudal ventral abdomen and prepuce. Surgery was performed and revealed that the umbilical hernia sac had ruptured, and confirmed that the left dorsal and ventral colon were present in the subcutaneous space. The mild degree of vascular compromise of the large colon did not necessitate resection and so it was replaced within the abdomen. The abdominal wall defect was closed and the subcutaneous dead space was reduced by using a walking suture pattern. Herniation of the large colon through the umbilicus with dissection through the subcutaneous tissues of the ventral abdominal wall and prepuce has not been previously reported in foals. Ultrasonography permits differentiation of herniated small intestine from large intestine.  相似文献   

希罗达治疗晚期结肠癌18例临床分析     

孙凤良 《吉林林学院学报》2007,(6):535-536

目的观察希罗达作为一线药物治疗晚期结肠癌的疗效及安全性.方法对18例具有可测量指标的晚期结肠癌患者采用希罗达2 500 mg/（m^2·d）,分早晚2次服用,用药前予格拉司琼预防呕吐,防止喉痉挛,减少末梢神经副反应,21 d为1周期,完成2周以上评价疗效.18例患者共完成78周期.结果CR 0例,PR 8例（44.4%）,总有效率44.4%,NC 8例（44.5%）,PD 2例（11.1%）.结论希罗达作为一线药物治疗晚期结肠癌有较好疗效,副作用小,特别适宜于年老体弱患者.  相似文献   

双歧杆菌完整肽聚糖的体外抗肿瘤作用及对大鼠大肠肿瘤的影响   总被引：1，自引：0，他引：1  

蔡良真李姝君  官成浓 《湛江医学院学报》2005,23(5):500-502

目的：观察双歧杆菌完整肽聚糖（WPG）体外抗肿瘤作用及对大鼠大肠肿瘤的影响。方法：采用MTT法检测双歧杆菌WPG对人结肠癌细胞株LS-174T、人胃粘膜上皮细胞株GES-1的杀伤作用。以二甲肼（DMH）为诱发荆,观察双歧杆菌WPG对大鼠大肠肿瘤的防治作用;DMH诱癌及双歧杆菌WPG灌胃时间为18周,在第33周结束实验。结果：双歧杆菌WPG在体外对人结肠癌细胞株具有显著的选择性杀伤作用,体内给药可明显降低大鼠大肠肿瘤发生率（60％vs100％,P〈0．01）．但大肠癌平均个数及肿瘤体积指数的差异无显著性（P〉0．05）。结论：双歧杆菌的WPG对DMH诱导的大鼠大肠肿瘤具有预防作用。  相似文献