Bioactive Peptides from Algae: Traditional and Novel Generation Strategies,Structure-Function Relationships,and Bioinformatics as Predictive Tools for Bioactivity     

Jack O&#x;Connor  Marco Garcia-Vaquero  Steve Meaney  Brijesh Kumar Tiwari 《Marine drugs》2022,20(5)

Over the last decade, algae have been explored as alternative and sustainable protein sources for a balanced diet and more recently, as a potential source of algal-derived bioactive peptides with potential health benefits. This review will focus on the emerging processes for the generation and isolation of bioactive peptides or cryptides from algae, including: (1) pre-treatments of algae for the extraction of protein by physical and biochemical methods; and (2) methods for the generation of bioactive including enzymatic hydrolysis and other emerging methods. To date, the main biological properties of the peptides identified from algae, including anti-hypertensive, antioxidant and anti-proliferative/cytotoxic effects (for this review, anti-proliferative/cytotoxic will be referred to by the term anti-cancer), assayed in vitro and/or in vivo, will also be summarized emphasizing the structure–function relationship and mechanism of action of these peptides. Moreover, the use of in silico methods, such as quantitative structural activity relationships (QSAR) and molecular docking for the identification of specific peptides of bioactive interest from hydrolysates will be described in detail together with the main challenges and opportunities to exploit algae as a source of bioactive peptides.  相似文献   

γ-氨基丁酸超微绿茶粉辅助降血压功能研究   总被引：1，自引：0，他引：1  

谭俊峰  林智  彭群华  郭丽  吕海鹏 《茶叶科学》2012,32(5):461-464

参照《保健食品检验与评价技术规范2003版》对γ-氨基丁酸(GABA)超微绿茶粉进行辅助降血压功能评价.动物实验设低、中、高(0.83、1.67、5.00 g/kg)3个剂量组,分别相当于人体推荐剂量的5、10、30倍.另设高血压模型对照组和正常动物高剂量对照组.经口连续给予样品30d,结果显示:高剂量组(5.00 g...  相似文献   

Calcium channel blocker toxicity   总被引：1，自引：1，他引：0  

Merilee Costello  DVM  DACVECC    Rebecca S. Syring  DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2008,18(1):54-60

Objective: Calcium channel blockers (CCB) are frequently prescribed for veterinary patients and the incidence of toxicosis secondary to these agents is increasing. The purpose of this review is to discuss toxicity of these agents and review therapeutic options. Etiology: Calcium plays a vital role in maintaining cellular functions within the cardiovascular system. Toxicosis secondary to these drugs can have deleterious effects on vascular tone, cardiac contractility, as well as electrical conduction in the heart. Diagnosis: The intitial diagnosis is often made based on history of ingestion, physical examination and electrocardiography. Definitive diagnosis of CCB overdose can be made via quantification of serum concentrations of the drug ingested. Therapy: Initial therapy should consist of inducing emesis and administration of activated charcoal. Other potential therapies include intravenous calcium, parasympatholytics, sympathomimetics, glucagon, insulin and dextrose, placement of a temporary pacemaker, or calcium channel agonists. Prognosis: There is little data on the outcome of CCB toxicosis. Aggressive management of these cases is necessary to try and minimize morbidity and mortality.  相似文献   

Functional Properties of Ethyl Acetate-methanol Extract of Commonly Edible Molluscs     

Soumya Krishnan 《Journal Of Aquatic Food Product Technology》2013,22(7):729-742

ABSTRACT

Marine molluscs are consumed as culinary delicacies and represent a relatively untapped source of natural functional food ingredients. The bioactive potential of ethyl acetate-methanol (C₂H₅OAc/CH₃OH) extract of molluscs Uroteuthis duvaucelii, Amphioctopus marginatus, Crassostrea madrasensis, and Sepiella inermis were demonstrated using different in vitro systems. The C₂H₅OAc/CH₃OH extract of A. marginatus displayed greater 2, 2-diphenyl-1-picryl-hydrazil (IC₉₀ 1.76 mg mL^?1) radical quenching capacity along with potential hydroxymethylglutaryl coenzyme-A reductase (HMGCR)-inhibiting activity (IC₉₀ 1.21 mg mL^?1) and angiotensin converting enzyme-I inhibitory property (ACE-I) (IC₉₀ 0.87 mg mL^?1) compared to those displayed by other molluscs. The organic extract of S. inermis set forth significantly higher pro-inflammatory 5-lipoxygenase inhibitory property (IC₉₀ 1.96 mg mL^?1) along with potential antidiabetic activity as determined by dipeptidyl peptidase-4 (DPP-4) antagonistic activities (IC₉₀ 2.62 mg mL^?1, P < .05). Significant correlations were observed between bioactive properties and electronegative groups of organic extracts of a mollusc. The free radical quenching property of the extracts exhibited a positive correlation towards other bioactivities, implicating the role of antioxidant property of the compounds in the extract to inhibit lifestyle ailments. The present study indicated that S. inermis and A. marginatus could be utilized as functional food ingredients to combat hypertension, hyperlipidemia, and inflammation-related risks.  相似文献