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Two new cembranoids, namely, sinumerolides A and B （1 and 2）, one new steroid, 7fl-hydroxygorgosterol （7）, along with four known cembranoid derivatives （3-6）, four known steroids （8-11）, and four known... 相似文献
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Chia-Chi Peng Chiung-Yao Huang Atallah F. Ahmed Tsong-Long Hwang Jyh-Horng Sheu 《Marine drugs》2020,18(11)
The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F–L (1–7). The chemical structures of 1–7 were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of 1–7 against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (2) and cherbonolide H (3) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively. 相似文献
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Zhifang Xi Wei Bie Wei Chen Dong Liu Leen van Ofwegen Peter Proksch Wenhan Lin 《Marine drugs》2013,11(9):3186-3196
Four new cembrane-type diterpenoids, sarcophyolides B–E (1–4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1–4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells. 相似文献
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Mahmoud A. A. Ibrahim Alaa H. M. Abdelrahman Mohamed A. M. Atia Tarik A. Mohamed Mahmoud F. Moustafa Abdulrahim R. Hakami Shaden A. M. Khalifa Fahad A. Alhumaydhi Faris Alrumaihi Syed Hani Abidi Khaled S. Allemailem Thomas Efferth Mahmoud E. Soliman Paul W. Par Hesham R. El-Seedi Mohamed-Elamir F. Hegazy 《Marine drugs》2021,19(7)
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Yao-Tsung Yeh Sung-Chun Lin Gene-Hsiang Lee Zhi-Hong Wen Tsong-Long Hwang Yu-Jen Wu Jih-Jung Chen Lee-Shing Fang Mei-Kang Yuan Ping-Jyun Sung 《Marine drugs》2021,19(3)
Two cembranoids, including a new compound, lobocrassin I (1), as well as a known analogue, lobohedleolide (2), were obtained by solvent extraction from octocoral Lobophytum crassum. This study employed a spectroscopic approach to establish the structures of these two cembranoids, and utilized single-crystal X-ray diffraction analysis to determine their absolute configurations. The results of biological activity assays demonstrated that cembranoid 2 exhibited bioactivity against the protein expressions of inducible nitric oxide synthase (iNOS) lipopolysaccharide (LPS)-treated RAW 264.7 mouse macrophage cells. 相似文献
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