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A comparative study between responses of isolated bovine and equine digital arteries to vasoactive mediators 
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下载免费PDF全文 C. Zizzadoro M. Caruso S. Punzi G. Crescenzo F. Zongoli C. Belloli 《Journal of veterinary pharmacology and therapeutics》2018,41(1):51-59
Hemodynamic perturbations, partly resulting from abnormal vasoconstriction of digital vessels, have been implicated in the pathogenesis of bovine and equine laminitis. This study compared the responsiveness of isolated bovine (BDA) and equine (EDA) digital arteries to pharmacological agents that stimulate receptor systems involved in the regulation of normal vessel tone. The role of the endothelium and the short‐ and longer‐term effects of an experimentally induced endothelial damage were also evaluated. Species‐related differences were found in the vessel reactivity to all of the receptor agonists tested. In intact BDA, as compared to intact EDA, norepinephrine was a more effective vasoconstrictor, 5‐hydroxytryptamine a more effective but less potent vasoconstrictor, isoproterenol a less effective vasodilator and carbamylcholine a less potent vasodilator. In BDA, but not in EDA, the contractile responses to norepinephrine and 5‐hydroxytryptamine were enhanced immediately after endothelium removal. However, the contractile reactivity of denuded BDA returned to basal values following overnight incubation. The differences suggest species specificity for the pathophysiology of digital vasomotor tone and function in horses and cattle. 相似文献
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Pigatto JA Andrade MC Laus JL Santos JM Brooks DE Guedes PM Barros PS 《Veterinary ophthalmology》2004,7(3):205-208
The objective of this study was to examine the endothelial surface morphology and to perform morphometric analysis of the corneal endothelial cells of Yacare caiman (Caiman yacare) using scanning electron microscopy. Morphometric analysis with regard to polygonality, mean cell area, cell density and coefficient of variation of mean cell area was performed. Cell areas were measured using image analysis software. The normal corneal endothelium of Yacare caiman consisted of polygonal cells of uniform size and shape with interdigitations of the cell borders. Microvilli appeared as protrusions on the cellular surface. The average cell area was 270 +/- 24 microm(2) and the endothelial cell density was 3704 +/- 324 cells/mm(2). The coefficient of variation of cell area was 0.22. This study demonstrates that the Yacare caiman corneal endothelium is similar to those described in other vertebrates. 相似文献
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普洱茶调节SD大鼠血脂及保护血管内皮的研究 总被引：2，自引：1，他引：1
采用治疗性给予普洱茶的方法,探讨普洱茶调节血脂、保护血管内皮及抗动脉粥样硬化的作用和机制。通过SD大鼠高脂饲料造模28 d后,给予不同剂量普洱茶35 d。试验期间检测所有动物的体重变化;试验结束后检测血脂水平及血浆一氧化氮（NO）,并进行主动脉病理组织学检查。结果表明,普洱生茶及熟茶组与模型组比较：（1）体重明显减轻;（2）血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）明显降低,血浆NO浓度增加;（3）主动脉血管壁内皮细胞损伤减轻,血管内皮素-1（ET-1）表达减少。通过研究认为,治疗性给予普洱茶,能够降低高脂饲料饲喂SD大鼠的体重及血脂水平,熟茶作用更显著;普洱茶具有保护血管内皮的作用,其作用机制可能与它促进NO合成,抑制ET-1合成有关。 相似文献
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Juliane Rieger Sabine Kaessmeyer Salah Al Masri Hana Hünigen Johanna Plendl 《Anatomia, histologia, embryologia》2020,49(5):656-678
The cardiovascular system is the first functional organ in the embryo, and its blood vessels form a widespread conductive network within the organism. Blood vessels develop de novo, by the differentiation of endothelial progenitor cells (vasculogenesis) or by angiogenesis, which is the formation of new blood vessels from existing ones. This review presents an overview of the current knowledge on physiological and pathological angiogenesis in the horse including studies on equine endothelial cells. Principal study fields in equine angiogenesis research were identified: equine endothelial progenitor cells; equine endothelial cells and angiogenesis (heterogeneity, markers and assessment); endothelial regulatory molecules in equine angiogenesis; angiogenesis research in equine reproduction (ovary, uterus, placenta and conceptus, testis); angiogenesis research in pathological conditions (tumours, ocular pathologies, equine wound healing, musculoskeletal system and laminitis). The review also includes a table that summarizes in vitro studies on equine endothelial cells, either describing the isolation procedure or using previously isolated endothelial cells. A particular challenge of the review was that results published are fragmentary and sometimes even contradictory, raising more questions than they answer. In conclusion, angiogenesis is a major factor in several diseases frequently occurring in horses, but relatively few studies focus on angiogenesis in the horse. The challenge for the future is therefore to continue exploring new therapeutic angiogenesis strategies for horses to fill in the missing pieces of the puzzle. 相似文献
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Simon Comerma‐Steffensen Arnaldo Risso Elias Ascanio‐Evanoff Hector Zerpa 《Journal of veterinary pharmacology and therapeutics》2019,42(3):361-367
Endothelial dysfunction contributes to the development of ungulate's laminitis. Although extensively studied in equines, the endothelial function is not fully examined in bovine digital veins (BDVs). BDVs were studied under isometric conditions to describe the acetylcholine (ACh) endothelium‐dependent relaxation. Concentration–response curves were constructed to phenylephrine, ACh, and sodium nitroprusside (SNP). Relaxation responses were evaluated using either phenylephrine or depolarizing high‐potassium Krebs solution (DKS) as precontraction agents. Endothelium denudation and incubation with L‐NAME (300 μM), indomethacin (10 μM) or both were used to explore endothelial‐mediated mechanisms. Endothelium denudation did not modify phenylephrine and SNP responses, however, significantly (p < 0.05) converted a relaxation (63.2 ± 5%) response to ACh into a contraction (30.3±9%). The ACh‐evoked relaxation was significantly (p < 0.05) reduced in the presence of indomethacin (37.5 ± 6%) and L‐NAME (6.40 ± 2%). The presence of both inhibitors abolished the ACh‐evoked relaxation. Although DKS caused a higher precontraction than phenylephrine, ACh‐evoked relaxation (22.4 ± 3.4%) was still observed and was reduced by the combination of inhibitors (7.0 ± 1.0%). The ACh endothelium‐dependent relaxation in BDVs is essentially mediated by nitric oxide and endothelium‐derived prostanoids. The BDV endothelium function is a dynamic component in the control of the bovine digital blood flow, particularly under endothelial dysfunction conditions when venoconstriction might lead to postcapillary resistance increase. 相似文献
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