胶原纤维固化黑荆树单宁对钪吸附的研究     

王碧  张凤金  覃松  廖学品 《林产化学与工业》2008,28(1):33-38

以胶原纤维为基质,通过醛交联剂将黑荆树单宁固化在胶原纤维上,制备了胶原纤维固化黑荆树单宁(IBWT)吸附材料并研究了IBWT对钪离子(Sc3 )的吸附特性.结果表明:在HOAc-NaOAc介质中,IBWT对Sc3 具有较强的吸附能力.50℃下,当溶液中Sc3 的质量浓度为100mg/L、pH值为6.40时,吸附容量达到83.3mg/g.IBWT对Sc3 的平衡吸附量随pH值和温度的升高而升高.吸附过程为吸热过程,吸附平衡符合Langmuir方程.IBWT对Sc3 的吸附主要为化学吸附.进一步实验表明,IBWT经3次重复使用后对Sc3 的吸附容量基本不变.  相似文献   

Antiproliferative Properties of Scandium Exopolysaccharide Complexes on Several Cancer Cell Lines     

Javier Muoz-Garcia  Mattia Mazza  Cyrille Alliot  Corinne Sinquin  Sylvia Colliec-Jouault  Dominique Heymann  Sandrine Huclier-Markai 《Marine drugs》2021,19(3)

Antimetastatic properties on both murine and human osteosarcoma cell lines (POS-1 and KHOS) have been evidenced using exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium. These derivatives had no significant effect on the cell cycle neither a pro-apoptotic effect on osteosarcoma cells. Based on this observation, these EPSs could be employed as new drug delivery systems for therapeutic uses. A theranostic approach, i.e., combination of a predictive biomarker with a therapeutic agent, has been developed notably by combining with true pair of theranostic radionuclides, such as scandium ⁴⁷Sc/⁴⁴Sc. However, it is crucial to ensure that, once complexation is done, the biological properties of the vector remain intact, allowing the molecular tropism of the ligand to recognize its molecular target. It is important to assess if the biological properties of EPS evidenced on osteosarcoma cell lines remain when scandium is complexed to the polymers and can be extended to other cancer cell types. Scandium-EPS complexes were thus tested in vitro on human cell lines: MNNG/HOS osteosarcoma, A375 melanoma, A549 lung adenocarcinoma, U251 glioma, MDA231 breast cancer, and Caco2 colon cancer cells. An xCELLigence Real Cell Time Analysis (RTCA) technology assay was used to monitor for 160 h, the proliferation kinetics of the different cell lines. The tested complexes exhibited an anti-proliferative effect, this effect was more effective compared to EPS alone. This increase of the antiproliferative properties was explained by a change in conformation of EPS complexes due to their polyelectrolyte nature that was induced by complexation. Alterations of both growth factor-receptor signaling, and transmembrane protein interactions could be the principal cause of the antiproliferative effect. These results are very promising and reveal that EPS can be coupled to scandium for improving its biological effects and also suggesting that no major structural modification occurs on the ligand.  相似文献