Placement of an indwelling percutaneous gastrotomy (PEG) tube for the measurement of intra‐gastric pH in two horses          下载免费PDF全文

B. W. Sykes  C. M. McGowan  P. C. Mills 《Equine Veterinary Education》2015,27(12):627-632

Intra‐gastric pH monitoring is an important tool in the validation of acid suppressive drugs. To date, several methods of monitoring intra‐gastric pH in the horse have been described. However significant limitations are present in the existing models. This article describes the placement of a percutaneous gastrotomy (PEG) tube secured with a button gastropexy in the standing horse through which the pH of the ventral stomach can readily be measured under both fed and fasted conditions.  相似文献   

Rethinking equine gastric ulcer syndrome: Part 2 – Equine squamous gastric ulcer syndrome (ESGUS)          下载免费PDF全文

B. W. Sykes  J. M. Jokisalo 《Equine Veterinary Education》2015,27(5):264-268

It has recently been highlighted that significant differences in prevalence, risk factors and the response to treatment exist between ulceration of the squamous gastric mucosa and ulceration of the glandular gastric mucosa in the horse. In the first article in the series, the term equine squamous gastric ulcer syndrome (ESGUS) was used to describe disease of the squamous gastric mucosa with clinical signs and diagnosis discussed. The purpose of this article is to review the pathophysiology, risk factors, prevalence, treatment and prevention of ESGUS.  相似文献   

Basal H2-receptor stimulated and pH-dependent acid secretion from an isolated stomach mucosa preparation of the cod,Gadus morhua,studied using a modified pH-static titration method     

Peter Bomgren  Ann-Cathrine Jönsson 《Fish physiology and biochemistry》1996,15(4):275-285

Gastric acid secretion from isolated cod stomach mucosa was measured using a pH-static titration method. A basal acid secretion rate (BASR) of 6.0±0.6 nEqH⁺min^–1cm^–1 was measured when using 0.9% NaCl as luminal solution. There was a dose-dependent increase in response to histamine between 0.12 and 0.20 M (EC₅₀=0.15 M), above which gastric acid secretion plateaued at 13.5±1.8 nEqH⁺min^–1cm^–1. Ranitidine, a H₂-receptor antagonist, completely blocked the stimulatory effect of histamine and reduced the BASR. The H₁-receptor antagonist, clemastine, did not inhibit the response to histamine. Acid secretion rates decreased significantly when the pH of the luminal side of the mucosa was lowered from pH 5.75 to pH 4.50, indicating that a negative feedback mechanism was operating. Histological staining showed that oxynticopeptic cells were uniformly distributed throughout the cardiac stomach.It is concluded that the acid secretion in the isolated stomach mucosa of cod can be measuredin vitro with a pH-static titration method. The method was used to demonstrate that the BASR is downregulated by a decrease in pH. Furthermore, we conclude that the histamine receptor in the cod stomach mucosa resembles the mammalian H₂-receptor and that histamine is secreted under basal conditions.  相似文献