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H. Hu A. Barker T. Harcourt‐Brown N. Jeffery 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2015,29(6):1456-1463
Intracranial neoplasia is commonly diagnosed in dogs and can be treated by a variety of methods, but formal comparisons of treatment efficacy are currently unavailable. This review was undertaken to summarize the current state of knowledge regarding outcome after the treatment of intracranial masses in dogs, with the aim of defining optimal recommendations for owners. This review summarizes data from 794 cases in 22 previously published reports and follows PRISMA guidelines for systematic review. A Pubmed search was used to identify suitable articles. These then were analyzed for quality and interstudy variability of inclusion and exclusion criteria and the outcome data extracted for summary in graphs and tables. There was a high degree of heterogeneity among studies with respect to inclusion and exclusion criteria, definition of survival periods, and cases lost to follow‐up making comparisons among modalities troublesome. There is a need for standardized design and reporting of outcomes of treatment for brain tumors in dogs. The available data do not support lomustine as an effective treatment, but also do not show a clear difference in outcome between radiotherapy and surgery for those cases in which the choice is available. 相似文献
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This case report presents a Belgian Shepherd Malinois dog affected by hemophilia A recognized at the age of seven months. The clinical follow-up including all the diagnostic procedures leading to the final diagnosis and the course of this disorder are presented. 相似文献
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W.‐L. Hsu Y.‐S. Lin Y.‐Y. Hu M.‐L. Wong F.‐Y. Lin Y.‐J. Lee 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(2):437-442
Background
Neutrophil gelatinase–associated lipocalin (NGAL) is released from renal tubular cells after injury and serves in humans as a real‐time indicator of active kidney damage, including acute kidney injury (AKI) and chronic kidney disease (CKD). However, NGAL concentrations in dogs with naturally occurring AKI or CKD rarely have been explored in detail.Hypothesis/Objectives
The goal of this study was to evaluate whether NGAL can serve as a useful biomarker in dogs with naturally occurring renal disease.Animals
Client‐owned dogs with renal disease (57) and control dogs without any disease (12) were examined.Methods
Serum NGAL (sNGAL) and urine NGAL (uNGAL) concentrations were measured in each animal by a newly developed ELISA system. Demographic, hematologic, and serum biochemical data were recorded. Survival attributable to AKI and CKD was evaluated at 30 days and 90 days, respectively.Results
Serum and urine NGAL concentrations in azotemic dogs were significantly higher than in nonazotemic dogs and were highly correlated with serum creatinine concentration (P < .05). Among CKD dogs, death was associated with significantly higher sNGAL and uNGAL concentrations compared with survivors. Receiver‐operating characteristic curve (ROC) analysis showed that sNGAL was better than serum creatinine concentration when predicting clinical outcomes for CKD dogs (P < .05). The best cutoff point for sNGAL was 50.6 ng/mL, which gave a sensitivity and a specificity of 76.9 and 100%, respectively. Furthermore, dogs that had higher concentrations of sNGAL survived for a significantly shorter time.Conclusion
sNGAL is a useful prognostic marker when evaluating dogs with CKD. 相似文献6.
Hollis AR Furr MO Magdesian KG Axon JE Ludlow V Boston RC Corley KT 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(5):1223-1227
Reasons for Performing Study: Critical illness is associated with hyperglycemia in humans, and a greater degree and duration of hyperglycemia is associated with nonsurvival. Hypoglycemia is also seen in critically ill humans, and is associated with nonsurvival. This might also be true in the critically ill foal.
Objectives: To investigate the association of blood glucose concentrations with survival, sepsis, and the systemic inflammatory response syndrome (SIRS).
Methods: Blood glucose concentrations at admission (515 foals) and 24 hours (159 foals), 36 hours (95), 48 hours (82), and 60 hours (45) after admission were analyzed. Logistic regression analyses were performed to investigate the association of glucose concentrations with survival, sepsis, a positive blood culture, or SIRS.
Results: 29.1% of foals had blood glucose concentrations within the reference range (76–131 mg/dL) at admission, 36.5% were hyperglycemic, and 34.4% were hypoglycaemic. Foals that did not survive to hospital discharge had lower mean blood glucose concentrations at admission, as well as higher maximum and lower minimum blood glucose concentrations in the 1st 24 hours of hospitalization, and higher blood glucose at 24 and 36 hours. Foals with blood glucose concentrations <2.8 mmol/L (50 mg/dL) or >10 mmol/L (180 mg/dL) at admission were less likely to survive. Hypoglycemia at admission was associated with sepsis, a positive blood culture, and SIRS.
Conclusions and Potential Relevance: Derangements of blood glucose concentration are common in critically ill foals. Controlling blood glucose concentrations may therefore be beneficial in the critically ill neonatal foal, and this warrants further investigation. 相似文献
Objectives: To investigate the association of blood glucose concentrations with survival, sepsis, and the systemic inflammatory response syndrome (SIRS).
Methods: Blood glucose concentrations at admission (515 foals) and 24 hours (159 foals), 36 hours (95), 48 hours (82), and 60 hours (45) after admission were analyzed. Logistic regression analyses were performed to investigate the association of glucose concentrations with survival, sepsis, a positive blood culture, or SIRS.
Results: 29.1% of foals had blood glucose concentrations within the reference range (76–131 mg/dL) at admission, 36.5% were hyperglycemic, and 34.4% were hypoglycaemic. Foals that did not survive to hospital discharge had lower mean blood glucose concentrations at admission, as well as higher maximum and lower minimum blood glucose concentrations in the 1st 24 hours of hospitalization, and higher blood glucose at 24 and 36 hours. Foals with blood glucose concentrations <2.8 mmol/L (50 mg/dL) or >10 mmol/L (180 mg/dL) at admission were less likely to survive. Hypoglycemia at admission was associated with sepsis, a positive blood culture, and SIRS.
Conclusions and Potential Relevance: Derangements of blood glucose concentration are common in critically ill foals. Controlling blood glucose concentrations may therefore be beneficial in the critically ill neonatal foal, and this warrants further investigation. 相似文献
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Hollis AR Boston RC Corley KT 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(5):1099-1103
BACKGROUND: Hyperglycemia in critically ill humans is associated with increased glucose production and insulin resistance and is associated with death. This might also be true in horses presenting with acute abdominal disease. HYPOTHESIS: Throughout hospitalization, hyperglycemia will be common in adult horses presenting with acute abdominal disease. Hyperglycemia will be associated with a worse prognosis for survival to hospital discharge. ANIMALS: Two hundred sixty-nine adult horses with acute abdominal disease. METHODS: Observational retrospective study. Records were reviewed for 269 horses that had glucose data analysed and recorded at the time of hospital admission: 154 horses had a first sample after admission; 110 horses at 24 hours after admission; 74 horses at 36 hours after admission; and 49 horses at 48 hours after admission. Logistic regression analyses were performed to investigate the association of glucose concentrations with survival, in addition to the association of glucose concentrations with surgical, small intestinal, strangulating lesions, and lesions requiring a resection. RESULTS: Of 269 horses presenting with acute abdominal disease, 50.2% had blood glucose concentrations greater than the reference range (75.6-131.4 mg/dL); 0.4%, below the reference range; and 49.4%, within the reference range at admission. Of 269 horses, 2.3% had blood glucose concentrations below the reference range at some point during the first 48 hours of hospitalization, all of which had strangulating intestinal lesions. Horses that did not survive to hospital discharge had a higher mean blood glucose concentration at admission; at the first sample after admission; at 24, 36, and 48 hours after admission; and higher maximum and minimum blood glucose concentrations in the first 24 hours after admission. CONCLUSIONS AND CLINICAL IMPORTANCE: Derangements of blood glucose concentration are common in horses with acute abdominal disease. Hyperglycemia is much more common than hypoglycemia in these animals. Hyperglycemia in the first 48 hours of hospitalization is associated with a worse prognosis for survival to hospital discharge. 相似文献
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Recent systematic reviews have highlighted the lack of quality information with respect to the epidemiology of equine laminitis. The objectives of this study were to identify in Denmark, the risk factors for new (i.e., not believed to have suffered from laminitis previously) cases of laminitis (NL) and to look at the outcome and incidence of repeated episodes of laminitis in these animals as well as those which had previously suffered an episode of laminitis (i.e., chronic cases) over the following 12 months. Information was obtained from 110 veterinary diagnosed cases of laminitis (69 new and 41 chronic) and 80 control animals (the next nonlaminitic horse/pony seen by that participating practice). All animals were followed for up to 1 year. Univariable and multivariable conditional logistic regression was conducted for the NL case-control pairs. Variables were retained within the final multivariable models if the likelihood ratio P value was <.05. There was no association between sex or gender and laminitis. A recent change of grass, being on what was considered high-quality grass and being a cold-blooded type, <149 cm (i.e., Shetland, Fell, Welsh, or Dartmoor pony, Icelandic horse, Norwegian fjords, or a mix of these breeds) were all significant risk factors for laminitis. Although cresty neck score and body condition score were significantly associated with NL at the univariable screening stage, they were found to be confounders of breed and each other during the multivariable model building process. Other factors such as weight and estimated starch intake were not found to be significant. Thirty-three percent of all the laminitis cases had been humanely destroyed within 12 months of diagnosis, mainly for laminitis-associated reasons, compared with only 7.5% of the controls (none for laminitis associated reasons). This study confirms the importance of grass turnout and breed on laminitis risk. Horses in work at the time of diagnosis as well as those diagnosed in the winter and spring were more likely to be humanely destroyed within the next 12 months than those not in work or diagnosed in the autumn and summer. 相似文献
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在新的发展形势下,风景园林行业迎来了发展的新机遇,具有全面扎实的专业理论知识和较强的实践应用能力和创新能力的专业人才在人才市场上备受青睐。而实践教学体系设置科学与否直接影响着专业人才综合能力的培养。以成果导向教育理念（OBE）为指导,在反思的基础上,华南农业大学风景园林专业针对市场需求,反向设计实践教学课程、内容和教学手段,构建了分层阶梯式递进实践教学体系。通过注重教学内容更新与手段创新,校企紧密协同搭建实践创新平台,实施多元考核评价等措施,有效地提高了学生的实践学习产出。 相似文献