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J.M. Herring M.A. McMichael S.A. Smith 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2013,27(5):1020-1033
Microparticles (MPs), small membrane‐derived vesicles, are derived from many cell types and released into the circulation. Microparticles can express antigens, and contain cell surface proteins, cytoplasmic contents, and nuclear components from their cell of origin that determines their composition, characterization, and transfer of biologic information. Certain prompts for this release include shear stress, complement activation, proapoptotic stimulation, cellular damage, or agonist interaction with cell surface receptors. Release can be physiologic or pathologic and is associated with proinflammatory and procoagulant effects and has been implicated in thrombotic states. Microparticles also contribute to systemic inflammation and cardiovascular, hematologic, and oncologic disease states. The study of MPs in human medicine is rapidly advancing and extends into the physiology of health, the pathophysiology of disease, and the role of MPs in transfusion medicine. In veterinary medicine, published work on MPs has been limited to the area of inherited disorders, blood storage, and leukoreduction (LR). Microparticle research is still in its infancy, and this review should be seen as a snapshot of what is currently known. As research continues important limitations, including variations in preanalytic variables such as collection, storage, or centrifugation, and limitations of quantitation are coming to the forefront. Correlation of quantitation of MPs with assays of activity will hopefully shed light on the true nature of MPs in health and disease. This review will focus on the role of cellular exocytic vesiculation in health, disease, and transfusion medicine. 相似文献
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为了探究外泌体在卵泡中调控卵母细胞生长发育以及后续受精中的调控作用及机制,归纳了最近外泌体泡的文献。首先综述了外泌体的组成和功能,其次在此基础上选择重点阐述外泌体在卵泡中如何调控卵母细胞与卵泡体细胞的互作机制,然后进一步分析了外泌体介导精卵结合的调控机制。从而得出了外泌体在卵泡中通过其中包含的蛋白和RNA等物质调控卵母细胞生长发育的结论,建议在研究卵母细胞生长发育调控的研究方面应该重视对于外泌体的研究。最终,首次统性论述了外泌体对于卵母细胞的发育的影响,期望对于研究同行有一定的意义。 相似文献
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Maddur MS Mohan MS Gajendragad MR Gopalakrishna S Singh N 《Veterinary research communications》2008,32(6):481-489
Foot-and-mouth disease (FMD) is one of the most contagious diseases affecting wide range of host species with variable severity and decreased productivity. The present study was undertaken to compare the clinical and leucocytic changes in indigenous Indian cattle and buffaloes experimentally infected with FMD virus (FMDV) Asia 1. A mild type of disease was observed in the cattle, more so in buffaloes infected with FMDV. Difference in terms of type, site and healing of lesion was observed between cattle and buffaloes. Foot lesions were more common than tongue in buffaloes, which were mainly evident in bulb of the heel in contrast to interdigital foot lesions in cattle. Further, FMDV infection induced a transient moderate leucopenia with lymphopenia in both cattle and buffaloes, but monocyte levels diverged. Relationship between the raised body temperature, leucocytic changes and lesion development was observed. Microscopic changes were observed in the keratinized epithelium of tongue and foot. The findings of the present study indicated the need to investigate the early leucocytic changes in cattle and buffaloes in depth for better understanding of the disease process. 相似文献
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