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Acute toxicity in five dogs after ingestion of a commercial snail and slug bait containing iron EDTA 总被引：1，自引：1，他引：0
This case series of five dogs describes the effects of ingesting large amounts of an iron EDTA snail-bait product. In all cases signs of toxicity occurred between 6 and 24 h after ingestion and included abdominal pain and haemorrhagic gastroenteritis. Two of the dogs had pretreatment serum iron levels measured and in both cases the levels were above normal limits. All of the dogs were treated with iron chelation therapy and supportive care including intravenous fluids, analgesics, gastric protectants and antibiotics. Chelation therapy with desferrioxamine mesylate did not cause adverse effects in any of the dogs and all survived to discharge. The effects of iron EDTA snail bait in dogs requires further study and minimum toxic doses need to be established. 相似文献
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水体急性低氧一直是水产养殖中的棘手问题,而铁代谢在鱼类低氧应激中发挥着极其重要的作用。为探究铁离子对鱼类应激低氧胁迫的影响,本研究以模式生物斑马鱼的肝脏细胞（ZFL）为研究对象,利用柠檬酸铁胺（FAC）对ZFL细胞进行外源补铁,同时用去铁胺（DFO）清除ZFL细胞的内源及外源铁,比较不同处理条件下ZFL细胞对低氧胁迫的应激反应。结果表明,低氧胁迫显著降低了ZFL细胞的增殖能力和存活率,而与清除内源及外源铁相比,补充外源铁能够明显改善ZFL细胞的增殖能力和存活率。同时,Western blot的结果显示补充外源铁显著提高了低氧胁迫下的ZFL细胞中铁蛋白的表达量。此外,通过qRT-PCR比较在该条件下与铁吸收（tfa）、铁储存（fthl27、fthl28、fthl31）和铁输出（fpn）相关基因的mRNA表达水平,结果表明均显著提高。进一步对低氧胁迫下ZFL细胞内活性氧（ROS）水平进行检测,发现补充外源铁能够在一定程度上恢复ZFL细胞中ROS的水平,由此证明在一定范围内胞内ROS水平的增加有利于ZFL细胞抵抗低氧胁迫。可为探究低氧导致的鱼类相关疾病提供理论基础,为低氧导致养殖鱼类产量低下提供解决办法。 相似文献
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Wael M. Abdel-Mageed Lamya H. Al-Wahaibi Burhan Lehri Muneera S. M. Al-Saleem Michael Goodfellow Ali B. Kusuma Imen Nouioui Hariadi Soleh Wasu Pathom-Aree Marcel Jaspars Andrey V. Karlyshev 《Marine drugs》2021,19(5)
A Micromonospora strain, isolate MT25T, was recovered from a sediment collected from the Challenger Deep of the Mariana Trench using a selective isolation procedure. The isolate produced two major metabolites, n-acetylglutaminyl glutamine amide and desferrioxamine B, the chemical structures of which were determined using 1D and 2D-NMR, including 1H-15N HSQC and 1H-15N HMBC 2D-NMR, as well as high resolution MS. A whole genome sequence of the strain showed the presence of ten natural product-biosynthetic gene clusters, including one responsible for the biosynthesis of desferrioxamine B. Whilst 16S rRNA gene sequence analyses showed that the isolate was most closely related to the type strain of Micromonospora chalcea, a whole genome sequence analysis revealed it to be most closely related to Micromonospora tulbaghiae 45142T. The two strains were distinguished using a combination of genomic and phenotypic features. Based on these data, it is proposed that strain MT25T (NCIMB 15245T, TISTR 2834T) be classified as Micromonospora provocatoris sp. nov. Analysis of the genome sequence of strain MT25T (genome size 6.1 Mbp) revealed genes predicted to responsible for its adaptation to extreme environmental conditions that prevail in deep-sea sediments. 相似文献
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Katsushiro Miyamoto Hiroaki Kawano Naoko Okai Takeshi Hiromoto Nao Miyano Koji Tomoo Takahiro Tsuchiya Jun Komano Tomotaka Tanabe Tatsuya Funahashi Hiroshi Tsujibo 《Marine drugs》2021,19(12)
Vibrio vulnificus is a Gram-negative pathogenic bacterium that causes serious infections in humans and requires iron for growth. A clinical isolate, V. vulnificus M2799, secretes a catecholate siderophore, vulnibactin, that captures ferric ions from the environment. In the ferric-utilization system in V. vulnificus M2799, an isochorismate synthase (ICS) and an outer membrane receptor, VuuA, are required under low-iron conditions, but alternative proteins FatB and VuuB can function as a periplasmic-binding protein and a ferric-chelate reductase, respectively. The vulnibactin-export system is assembled from TolCV1 and several RND proteins, including VV1_1681. In heme acquisition, HupA and HvtA serve as specific outer membrane receptors and HupB is a sole periplasmic-binding protein, unlike FatB in the ferric-vulnibactin utilization system. We propose that ferric-siderophore periplasmic-binding proteins and ferric-chelate reductases are potential targets for drug discovery in infectious diseases. 相似文献
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