One-cycle growth studies with Maedi—Progressive pneumonia—Visna viruses: Shorter latent periods revealed     

R.S Trowbridge 《Comparative immunology, microbiology and infectious diseases》1979,2(4):545-550

The latent periods of Visna virus and of progressive pneumonia virus were demonstrated by one-cycle growth studies to end 14–16 hr after infection of sheep choroid plexus cell cultures. Maedi virus was demonstrated to have a 14–18-hr latent period.  相似文献   

Experimental studies of chronic pneumonia of sheep     

J.S Gilmour  G.E Jones  A.G Rae 《Comparative immunology, microbiology and infectious diseases》1979,1(4):285-293

Strains of Mycoplasma ovipneumoniae and Pasteurella haemolytica isolated from sheep affected with chronic pneumonia were inoculated by endobronchial route to conventionally-reared and SPF (Specific Pathogen-Free) lambs. Changes resembling those of the naturally-occurring disease were produced in most lambs given the organisms in combination and in some given M. ovipneumoniae alone. Similar but less extensive changes were seen in SPF lambs and fewer animals were affected. Different strains of M. ovipneumoniae did not affect the extent of changes produced in SPF lambs. M. ovipneumoniae became established in the lungs of both types of sheep; P. haemolytica did so less readily.

It was concluded that chronic pneumonia may be reproduced in conventional animals by combined inoculation of M. ovipneumoniae and P. haemolytica. Age and status of immunity to mycoplasmas may account for the different responses of conventional and SPF lambs.  相似文献   

Chronic fatigue syndrome (CFS) associated with Staphylococcus spp. bacteremia, responsive to potassium arsenite 0.5% in a veterinary surgeon and his coworking wife, handling with CFS animal cases     

Tarello W 《Comparative immunology, microbiology and infectious diseases》2001,24(4):233-246

Chronic fatigue syndrome (CFS) in human patients remain a controversial and perplexing condition with emerging zoonotic aspects. Recent advances in human medicine seem to indicate a bacterial etiology and the condition has already been described in horses, dogs, cats and birds of prey in association with micrococci-like organisms in the blood. To evaluate the possibility of a chronic bacteremia, a veterinary surgeon (the author) and his coworking wife, both diagnosed with CFS and meeting the CDC working case definition, were submitted to rapid blood cultures and fresh blood smears investigations. Blood cultures proved Staph-positive and micrococci-like organisms in the blood were repeatedly observed in the 3-year period preceding the arsenical therapy, during which several medicaments, including antibiotics, proved unsuccessful. Following treatment with a low dosage arsenical drug (potassium arsenite 0.5%, im., 1 ml/12 h, for 10 days) both patients experienced complete remission. At the post-treatment control made 1 month later, micrococci had disappeared from the blood, and the CD4/CD8 ratio was raising.

Résumé

L'étiologie du Syndrome de Fatigue Chronique (SDF) chez l'homme reste entourée de nombreuses spéculations et perplexités. Apparemment il s'agit d'une zoonose émergente qui a déjà été décrite chez les chevaux, les chiens, les chats et les oiseaux de proie, associée à la présence de bactéries types micrococciques trouvées dans le sang. Récente publications humaines semblent indiquer une étiologie bactériologique. Afin d'évaluer la possible association avec une infection chronique à bactéries, un vétérinaire practicien (l'auteur) e sa femme, avec un diagnostic de CFS et correspondant à la définition humaine pour cette maladie, on été soumis à hémocultures et à la recherche microscopique directe de germes dans le sang. Le hémocultures furent positives pour Staphylococcus spp. Chez les deux suject examinés, des bactéries type micrococciques ont été maintes fois retrouvées sur le globules rouges pendant les trois ans qui on précédé la thérapie arsenicale, et leur présence était associée aux symptomes de fatigue/douleur et à des anomalies biochimiques correspondantes. Au cours de la meme periode l'utilisations d'autre médicaments, y inclus des antibiotiques, n'avait sorti aucun résultat thérapheutique. En revanche, les symptômes ont disparu après traitement par l'arsenite de potassium à 0,5% (liqueur de fowler 1 ml/12 h pendant 10 jours). Cette thérapeutique a permis une guérison complète et durable du syndrome chez les deux sujets et l'augmentation du rapport CD4/CD8.  相似文献   

Experimental chlamydial pneumonia in pigs     

J W Harris  A R Hunter  D A McMartin 《Comparative immunology, microbiology and infectious diseases》1984,7(1):19-26

Naturally occurring disease in pigs associated with chlamydial infections has not been reported in Britain, though evidence of chlamydial challenge has been demonstrated in two separate serological surveys. An isolate of Chlamydia psittaci (28/68) from an ovine pneumonia produced pneumonia in pigs following intratracheal inoculation. Transient pyrexia at 24 hr was followed by increased respiratory rates and inappetance which lasted for a further 48 hr in challenged pigs. Histologically acute exudative reactions were present in the lungs by 24 hr with proliferative changes predominating after 10 days. While variations in the concentrations of inocula were reflected by corresponding increases and/or decreases in gross lung damage, clinical signs and histological reactions were unaltered. Chlamydial organisms were recovered only from lung tissues.  相似文献