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试验表明，盐酸特比萘芬不同饲喂剂量均可导致犬淋巴细胞百分比、中性粒细胞百分比、白细胞数等血常规检测指标异常。盐酸特比萘酚在幼犬肝脏和肾脏中的毒性是慢性累积的，临床应用中推荐使用盐酸特比萘芬剂量为 5 mg/kg.d进行口服，连续给药不能超过 21d。 相似文献
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S. Handl U. Wehr J. Zentek S. Krammer‐Lukas 《Journal of animal physiology and animal nutrition》2009,93(1):76-82
Lactoferrin is a natural compound in the milk of mammals and was shown to influence the intestinal micro‐flora and the immune system in mice, calves, dogs and man. The present study was carried out to investigate the effect of orally administered bovine lactoferrin (0, 30, 60 and 120 mg/kg DM feed) on the intestinal morphology and lymphocyte colonization in 36 motherless raised puppies. Endoscopic biopsies from duodenum and colon, taken in week 14, were scored histologically after staining with haematoxylin and eosin (H&E) and lymphocytes (CD3+, CD4+, CD8+) and plasma cells (IgA+, IgG+, IgM+) were enumerated after immunohistochemical staining by computer‐aided quantification. Histological scoring revealed no significant differences amongst the groups. IgG+ plasma cells were reduced (p < 0.05) in the lamina propria of the colon of the 30 and the 60 mg group. The number of CD8+ lymphocytes was higher (p < 0.05) in the epithelium of the colon of the lactoferrin groups. In conclusion, this study indicated only minimal effects of bovine lactoferrin on the population of selected immune cells in the gut mucosa of puppies. More investigations are needed to describe the impact of lactoferrin on the digestive physiology of puppies. 相似文献
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本研究旨在评价唾液乳酸杆菌TCSL1对犬生长性能、血液学与血清生化指标及肠道健康的影响,为研发犬用益生菌制剂奠定基础。选取24只6周龄左右的健康中华田园犬,随机分为4组,每组6只。试验组按低（5×106 CFU/mL）、中（5×108 CFU/mL）、高（5×1010 CFU/mL）剂量分别口服唾液乳酸杆菌TCSL1,对照组口服生理盐水,进行为期28 d的喂养试验。试验期间,定期观察并记录犬的行为、饮食和腹泻情况,28 d后分别称重,计算犬体重增长量。采集血液样品检测血液学、血清生化、肠道屏障与炎性细胞因子指标;采集粪便检测分泌型球蛋白sIgA含量和肠道主要细菌数量。结果表明,①与对照组相比,试验组均能促进犬体重的增长,降低腹泻率,与口服剂量呈正相关。淋巴细胞数、红细胞数、免疫球蛋白和碱性磷酸酶含量等均有升高趋势,丙氨酸氨基转氨酶和尿素氮等含量呈降低趋势,组间差异显著（P<0.05）;②随口服唾液乳酸杆菌剂量的增加,试验组血清中的二胺氧化酶（DAO）、D-乳酸（D-lactic acid）和脂多糖（LPS）等肠道屏障指示因子含量显著下降（P<0.05）;③试验组血清促炎细胞因子TNF-α和IL-6含量显著降低（P<0.05）,抗炎细胞因子TGF-β1和IL-10含量则显著升高（P<0.05）;④试验组粪便中的分泌型免疫球蛋白sIgA含量显著增加（P<0.05）,大肠杆菌和肠球菌数量显著下降（P<0.05）,乳酸杆菌和双歧杆菌的数量显著增加（P<0.05）。以上结果表明,口服唾液乳酸杆菌TCSL1可改善幼犬生长性能、增强肠道健康,降低腹泻率,以每天5×1010 CFU/mL剂量口服效果最佳。 相似文献
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Abstract Cutaneous and mucosal carriage of Staphylococcus intermedius was determined in five Cavalier King Charles spaniel bitches, living in normal domestic environment, and their 18 puppies during the immediate prepartum period and after whelping, over a total of 8 weeks, using quantitative swab techniques. Within 8 h of birth S. intermedius was isolated from each puppy. The nose and mouth were the most frequently colonized mucosal sites (83 and 78%, respectively). At that time S. intermedius was isolated from the abdominal skin in 78% of the puppies. One day postpartum the mucosal populations increased significantly ( P < 0.001) but fell 6 ( P < 0.01) and 20 ( P < 0.001) days later. Populations from abdominal skin reduced during the first and fourth weeks postpartum ( P < 0.05 for both). This study indicates that in the domestic environment S. intermedius establishes itself soon after birth. The level of colonization by S. intermedius in the bitches seems to influence the colonization by pathogenic staphylococci in puppies. 相似文献
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Age‐related changes in hematologic and serum biochemical variables in dogs aged 16–60 days 
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【目的】 研究复合微生态制剂对哺乳期比格幼犬生长性能与肠道菌群结构的影响。【方法】 选取12只15日龄比格犬, 随机分为对照组和微生态制剂组, 每组6只。微生态制剂组幼犬每日灌喂犬用微生态制剂20 mL, 对照组幼犬灌喂生理盐水20 mL, 于试验第0、3、9、12、15、18、21、25、28 d测量体重并计算净增重, 第28天采集全血样、血清样和粪样。全血样进行红细胞(RBC)计数和血红蛋白(HGB)浓度测定, 血清样检测碱性磷酸酶(AKP)、无机磷(IP)、总胆固醇(TCHO)、甘油三酯(TG)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、白介素-1β(IL-1β)、脂多糖(LPS)含量; 粪样进行菌群测序, 统计Goods coverage指数、Observed species指数和Shannon指数, 对样本进行PCoA分析, 并统计各样本在门、属、种水平上的物种分布。【结果】 与对照组相比, 微生态制剂可显著提高幼犬体重(P<0.05), 显著增加血清中RBC数量及HGB、AKP和IP含量(P<0.05), 促进比格幼犬生长发育; 微生态制剂可显著降低血清TG含量(P<0.05), 但对TCHO、IgA、IgG、IL-1β、LPS含量无显著影响(P>0.05)。Observed species指数和PCoA分析结果表明, 微生态制剂可显著改变幼犬肠道菌群结构(P<0.05)。在门水平上, 微生态制剂组幼犬肠道菌群拟杆菌门和放线菌门相对丰度显著降低(P<0.05), 梭菌门、酸杆菌门和疣微菌门相对丰度均显著增高(P<0.05);在属水平上, Escherichia-Shigella、霍尔德曼氏菌属、双歧杆菌属和布劳特氏菌属相对丰度均显著降低(P<0.05), 梭菌属、链球菌属、梭杆菌属、乳球菌属和片球菌属相对丰度均显著增高(P<0.05)。在种水平上, 大肠杆菌和短双歧杆菌相对丰度均显著降低(P<0.05), 犬大肠梭菌、格氏乳球菌、Vagococcus teuberi、贝莱斯芽孢杆菌、粪肠球菌和死亡梭杆菌相对丰度均显著增高(P<0.05)。【结论】 犬用微生态制剂可显著促进幼犬生长, 提高其血氧含量, 改变肠道菌群结构, 优化肠道菌群组成。 相似文献
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E. R. Campagnolo L. M. Philipp J. M. Long N. L. Hanshaw 《Zoonoses and public health》2018,65(3):304-311
Campylobacter is regarded as a leading cause of human bacterial gastroenteritis in the United States. We report on a case of laboratory‐confirmed Campylobacter jejuni infection in the Commonwealth of Pennsylvania among members of a household living with a laboratory‐confirmed but non‐speciated Campylobacter‐infected puppy. We describe an outbreak of likely dog‐associated campylobacteriosis, the risk factors, potential routes of exposure and the clinical features in the exposed family members, which began shortly after exposure to the recently purchased dog. We also provide public health recommendations to prevent Campylobacter infections in veterinary care providers, pet owners and those planning to adopt pets in the future. Finally, this report underscores the importance of the One Health approach when public health responders, human and animal healthcare providers and clinical diagnostic laboratories are tasked with developing effective strategies when investigating, detecting and responding to zoonoses (diseases shared between animals and humans). 相似文献
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通过对健康幼犬和腹泻幼犬的肠道菌群进行研究,对两者之间的差异进行探讨,以指导临床对腹泻的治疗。无菌采取健康幼犬和腹泻幼犬的粪便,通过选用不同选择性培养基,对其粪便微生物进行分离培养。比较两者菌群的差异,并筛选优势菌株,研究其生长特性以及通过生化试验进行确认。健康幼犬与腹泻幼犬粪便中常见细菌有肠杆菌、肠球菌、乳杆菌、双歧杆菌等,其数量的变化比较,腹泻幼犬粪便中肠球菌和乳酸杆菌的数量降低明显,双歧杆菌数量略有下降,肠杆菌的数量有不显著增加的趋势。肠道菌群失调易引起腹泻,临床上应正确治疗腹泻,避免滥用抗生素。 相似文献