Hypercalcaemia associated with chronic lymphocytic leukaemia in a Giant Schnauzer.     

M Kleiter  R Hirt  G Kirtz  M J Day 《Australian veterinary journal》2001,79(5):335-338

A 7-year-old male Giant Schnauzer was referred with a history of severe vomiting, lethargy, weight loss, polydipsia and polyuria. Detailed investigations revealed leucocytosis with a marked lymphocytosis, mild non-regenerative anaemia, thrombocytopenia, hypercalcaemia and azotaemia. Circulating lymphocytes were small and well-differentiated, and the same lymphoid population was present in bone marrow. Chronic lymphocyctic leukaemia with associated paraneoplastic hypercalcaemia was diagnosed. Immunohistochemical staining of a bone marrow biopsy revealed a neoplastic B-cell line expressing CD79. The dog responded to therapy with prednisolone and chlorambucil for a period of 8 months.  相似文献   

Electrocorticogram disturbances detected in rats exposed from early stages of life to residual doses of lindane     

P. Breton  I. Delamanche  F. Goudey Perrière 《Pesticide biochemistry and physiology》2005,81(2):97-104

Functional brain alterations induced by lindane were examined in Rat chronically exposed to low doses of lindane (1 and 2 μg L⁻¹ in drinking water) from conception. Histological and electrophysiological investigations were conducted at 14 weeks of age. Lindane did not induce histological changes. It did not significantly modify the sleep-wakefulness cycle and EEG did not show major alterations. The spectral EEG analysis, by recording cortical variations in both energy spectrum and energy levels of different frequency bands, showed an increase in the 11-15 Hz activity in both groups exposed to lindane. This activity was characterised by spindles well-depicted during slow wave sleep or associated with fast activity during wakefulness and theta activity in paradoxical sleep. These data suggest that chronic exposure to lindane doses as low as 1 μg L⁻¹ in drinking water could lead to central electrophysiological effects possibly involving GABA-benzodiazepine mechanisms.  相似文献   

Association of hyponatremia and hyperglycemia with outcome in dogs with congestive heart failure   总被引：1，自引：0，他引：1  

Colleen A. Brady  DVM  DACVECC    Dez Hughes  BVSc  MRCVS  DACVECC    Kenneth J. Drobatz  DVM  MSCE  DACVECC  DACVIM 《Journal of Veterinary Emergency and Critical Care》2004,14(3):177-182

Objective: To evaluate plasma sodium and glucose concentrations in dogs with congestive heart failure (CHF) prior to treatment and evaluate the differences between survivors and non‐survivors. Design: Retrospective study. Animals: Fifty‐nine dogs with CHF prior to receiving cardiac medication. Interventions: None. Measurements and main results: The mean plasma sodium concentration in dogs with CHF was below the reference range (144–156 mmol/L) and significantly lower (P=0.009) in non‐survivors (141±6 mmol/L) compared with survivors (147±4 mmol/L). The mean plasma glucose concentration was above the reference range (76–117 mg/dL) and significantly higher (P=0.004) in non‐survivors (128±52 mg/dL) compared with survivors (100±13 mg/dL). Forty‐four percent of non‐survivors had concurrent low plasma sodium and high plasma glucose concentrations, whereas no survivors had both abnormalities (P<0.0001). Conclusions: Lower plasma sodium and higher plasma glucose are associated with a worse outcome in dogs with CHF.  相似文献   

Effects of chronic dietary thiamethoxam and prothioconazole exposure on Apis mellifera worker adults and brood     

Sarah C Wood  Igor Medici de Mattos  Ivanna V Kozii  Colby D Klein  Ihor Dvylyuk  Crystani D A Folkes  Roney de Carvalho Macedo Silva  Igor Moshynskyy  Tasha Epp  Elemir Simko 《Pest management science》2020,76(1):85-94

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Independent Risk Factors Predicting Gradual Onset Injury in 2824 Trail Running Race Entrants: SAFER XVIII Study     

《The Forestry Chronicle》2021,32(3):293-301

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犬慢性肾衰竭进程中肠道菌群代谢物短链脂肪酸水平的变化及其对肾功能的影响   总被引：1，自引：0，他引：1  

刘静  朱道仙  卢劲晔  张一多  卢炜  陆江 《畜牧兽医学报》2021,52(8):2334-2343

本研究旨在评估短链脂肪酸在慢性肾衰竭患犬和健康犬中的水平,探究短链脂肪酸变化的原因及其对肾功能的影响。选取22例轻度慢性肾衰患犬（M-CRF组）、29例重度慢性肾衰患犬（S-CRF组）和26例健康对照犬（HC组）,用16S rDNA测序技术分析肠道菌群多样性,气相色谱法检测粪中短链脂肪酸浓度。通过粪菌移植和补充丁酸钠给5/6肾摘除犬,观察肠道菌群及丁酸钠对肾功能影响。结果显示：1）S-CRF组肠道菌群多样性指标观察物种数及Simpson指数低于HC组（P<0.05）,PCoA分析显示,S-CRF组肠道菌群与M-CRF、HC组有差异。2）LEfSe分析显示,S-CRF组和HC组间大量差异菌群,拟杆菌科、拟杆菌属及假单胞菌科等7个菌种富集于S-CRF组,普氏杆菌科、梭菌科、普氏杆菌属及普拉梭菌属等11个菌种富集于HC组。CCA分析发现富集于S-CRF组菌种丰度与肾功能指标呈正相关。3）S-CRF组粪中乙酸、丙酸及丁酸浓度均显著低于HC组和M-CRF组,M-CRF组丁酸浓度显著低于HC组（P<0.05）,且丁酸浓度与血中胱抑素C（Cys-c）、肌酐（Cr）及尿素氮（BUN）等肾功能指标呈负相关（r值分别为-0.451、-0.583和-0.514,P<0.01）。4）与慢性肾衰模型组（5/6 Nx组）比较,慢性肾衰犬给与丁酸钠8周后,血清Cr和BUN显著降低（P<0.05）;粪菌移植8周后,血清Cr和BUN显著升高（P<0.05）,丁酸钠可回调血清Cr和BUN水平。综上表明,慢性肾衰竭患犬肠道菌群多样性降低,菌群结构及丰度改变,粪中短链脂肪酸浓度降低,这些变化可加剧肾功能障碍。为犬慢性肾衰竭的防治提供新的理论依据。  相似文献   

Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs     

Alessio PIERINI  Giada ESPOSITO  Eleonora GORI  Elena BENVENUTI  Pietro RUGGIERO  George LUBAS  Veronica MARCHETTI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(2):248

Few studies have examined platelet alterations in dogs with chronic enteropathy. Our aim was to investigate platelet count (PLT), mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) in dogs diagnosed with immunosuppressant-responsive enteropathy (IRE). In this retrospective study of 41 dogs, data regarding signalment, canine chronic enteropathy clinical activity index (CCECAI), endoscopic and histopathological scores, PLT, MPV, PLR, total serum protein concentrations, albumin, and iron were collected. Clinical response and relapse were assessed with the evaluation of CCECAI over time. One month after starting therapy, dogs with >25% CCECAI reduction were considered responders. During a three-month CCECAI evaluation as part of a twelve-month follow-up, a CCECAI >3 together with a ≥2 unit increase in responder dogs was considered a relapse. PLT and PLR displayed significant negative correlation with MPV. MPV was positively correlated with total protein and albumin levels and negatively correlated with CCECAI. Three dogs were classified as non-responders, and 14 relapsed within 12 months. No differences were observed in PLT, MPV, or PLR between responding/non-responding and relapsing/non-relapsing groups. PLT, MPV, and PLR correlated with total protein, albumin, and CCECAI, confirming PLT as a potential marker, and suggesting MPV as a new marker of clinical efficacy against canine IRE.  相似文献   

Characterization of the intestinal mucosal proteome in cats with inflammatory bowel disease and alimentary small cell lymphoma     

Sina Marsilio  Floris C. Dres  Lawrence Dangott  Betty Chow  Steve Hill  Mark Ackermann  J. Scott Estep  Jonathan A. Lidbury  Jan S. Suchodolski  Jrg M. Steiner 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2021,35(1):179-189

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In-hospital development of an aorto-cardiac fistula in a Warmblood gelding with chronic renal disease     

R. E. Baker  J. W. Schlipf Jr  K. F. Scollan  N. L. LeBlanc  D. S. Russell 《Equine Veterinary Education》2021,33(4):e86-e91

A 20-year-old Warmblood gelding presented for evaluation and treatment of ventral oedema and azotaemia of unknown aetiology. On presentation, a diastolic heart murmur was appreciated and echocardiography revealed moderate aortic insufficiency due to chronic degenerative valve disease. The horse was hospitalised and failed to respond to oral and i.v. fluids and diuretics. Following discontinuation of all fluid and diuretic therapy, the horse became acutely agitated and developed monomorphic ventricular tachycardia. The ventricular tachycardia spontaneously converted to normal sinus rhythm, however the heart murmur changed in timing to a right basilar continuous murmur and bounding jugular pulses were noted. Repeat echocardiogram revealed an aorto-cardiac fistula with dissection into the basilar interventricular septum and left-sided chamber volume overload that was not previously present. Attempts at stabilisation were unsuccessful and euthanasia was elected. Post-mortem examination confirmed chronic renal disease of unknown aetiology in addition to an aorto-cardiac fistula originating from the right sinus of Valsalva with subsequent dissection into the basilar interventricular septum.  相似文献   

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis          下载免费PDF全文

Beatriz P Monteiro  Mary P Klinck  Maxim Moreau  Martin Guillot  Paulo VM Steagall  Daniel K Edge  Jean‐Pierre Pelletier  Johanne Martel‐Pelletier  Dominique Gauvin  Jérôme RE del Castillo  Eric Troncy 《Veterinary anaesthesia and analgesia》2016,43(6):643-651

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