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选择体重基本一致的30日龄齐卡兔60只(公母各半),随机分成5组,即A组(对照组)、B组、C组、D组和E组,每组3个重复,每重复4只,单笼饲养。其中对照组饲喂基础日粮,其余各组分别在基础日粮中添加喹赛多50mg/kg、喹赛多100mg/kg、喹乙醇50mg/kg、喹乙醇100mg/kg,进行为期60d的饲养试验。结果表明:各组添加剂均能显著提高肉兔日增重(P<0.05);100mg/kg喹赛多组与对照组日耗料量相当,而其它各组日耗料量则显著低于对照组(P<0.05);各试验组与对照组相比,均能显著降低料重比(P<0.05),但各试验组间差异不显著(P>0.05);各组添加剂均能降低肉兔腹泻率。综合评价,喹赛多组优于喹乙醇组,适宜添加量为100mg/kg。 相似文献
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高效液相色谱法测定猪血浆及组织中喹赛多及其脱二氧代谢物 总被引：1，自引：0，他引：1
建立了测定猪血浆及肝脏、肾脏、肌肉等组织中的喹赛多及其代谢物脱二氧喹赛多的高效液相色谱(HPLC)法.血浆样用甲醇沉淀蛋白后离心取上清液进样测定.组织样先用乙腈匀浆,用正己烷脱脂后作HPLC检测.色谱柱为ODS C18柱;流动相血浆样测定为乙腈水(2080),组织样测定为甲醇水(4258),流速为1.0 mL/min;紫外检测波长305 nm.药物工作液质量浓度范围为0.005～0.500 mg/L时,血浆样品及组织样品测定条件下药物质量浓度与响应值均具良好线性关系,相关系数＞0.999.血浆中药物质量浓度为0.02、0.10、0.50 mg/L时,喹赛多及脱二氧喹赛多的回收率均大于70%,组织中药物含量为0.05、0.20、1.00μg/g时,肌肉样品的回收率均大于70%,肝脏、肾脏样品则为50%～80%.本试验条件下,喹赛多及其脱二氧代谢物的最低检出质量浓度,血浆样品分别为0.01、0.02mg/L,组织样品2种检测物均为0.025μg/g.测定了工作液3种质量浓度0.01、0.05、0.25 mg/L的仪器精密度,日内相对偏差＜8.0%,日间相对偏差＜17.0%. 相似文献
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喹赛多及其主要代谢物在猪体内的药代动力学研究 总被引：3，自引：1，他引：2
试验研究了灌服单剂量喹赛多(40 mg/kg体重)后原药及其代谢物在健康猪体内的药代动力学特征。液相色谱-串联质谱法测定血浆中喹赛多及其代谢物的浓度,通过WinNonlin 5.2药代动力学软件分析,用非房室模型统计矩原理计算喹赛多及其代谢产物的药动学参数。主要药动学参数分别为喹赛多:t1/2 (7.52±1.77) h,Cmax(0.02±0.01) μg/mL,AUC(0-36 h) (0.26±0.24) (h·μg)/mL,MRT(11.37±3.21) h;N1(脱一氧喹赛多):t1/2 (3.05±1.12) h,Cmax(0.35±0.18) μg/mL,AUC(0-36 h) (2.13±2.31) (h·μg)/mL,MRT(11.83±3.34) h。N4(脱一氧喹赛多):t1/2 (2.91±1.15) h,Cmax(0.60±0.32) μg/mL,AUC(0-36 h) (3.78±4.28) (h·μg)/mL,MRT(11.00±2.86) h。脱二氧喹赛多:t1/2 (3.85±1.30) h,Cmax(0.46±0.19) μg/mL,AUC(0-36 h) (4.21±2.47) (h·μg)/mL,MRT(13.35±2.65) h。QCA(喹口恶啉-2-羧酸):t1/2 (5.08±0.57) h,Cmax(0.25±0.11) μg/mL,AUC(0-36 h) (3.05±1.46) (h·μg)/mL,MRT(15.15±1.83)h。结果表明,血浆中主要存在形式为代谢物,各代谢物的血药浓度及AUC(0-∞)均高于喹赛多,喹赛多消除半衰期最长,QCA平均滞留时间最长。 相似文献
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Dietary exposure assessment of cyadox based on tissue depletion of cyadox and its major metabolites in pigs,chickens, and carp 
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下载免费PDF全文 L. L. Huang Y. M. Qiu L. L. Sun J. Li Y. H. Pan Y. L. Wang Z. H. Yuan 《Journal of veterinary pharmacology and therapeutics》2018,41(1):125-136
The tissue kinetics of cyadox, an antibacterial agent used in food animals, and its major metabolites in pigs, chickens, and carp were investigated followed by a complete dietary exposure assessment to evaluate the food safety of cyadox. Cyadox and its major metabolites, bisdeoxycyadox (Cy1), 4‐desoxycyadox (Cy2), N ‐(quinoxaline‐2‐methyl)‐cyanide acetyl hydrazine (Cy4), quinoxaline‐2‐carboxylic acid (Cy6), and 2‐hydromethyl‐3‐hydroxy‐quinoxaline (Cy12), were simultaneously quantitated with a high‐performance liquid chromatography?ultraviolet (HPLC ‐UV ) method. Pigs, chickens, and carp were fed with 150 mg/kg cyadox in feed for consecutive 60, 40, and 30 days, respectively. The residue amount of cyadox and its major metabolites in liver, kidney, muscle, and fat (skin) tissues was determined. Cy2 was below the limit of quantitation even at the withdrawal time of 6 hr, cyadox, Cy4, Cy6, and Cy12 could be detected at 6–24 hr with low level less than 50 μg/kg. By contrast, Cy1 persisted for 3 days in the kidney of pigs and chickens, and in the liver of carp. Based on these residue depletion data and previous toxicology results, the global estimated chronic dietary exposure assessment of cyadox for general population was conducted, indicating a zero withdrawal time (WDT ) may be appropriate for cyadox in food animals when used in feed for prolonged administration. These results provide analytical techniques and safety standards suitable for residue monitoring of cyadox in food animals. 相似文献
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喹赛多对猪直肠粪便中大肠杆菌数及肠黏膜免疫影响 总被引：1，自引：0，他引：1
去势长大仔猪随机分为6组，Ⅰ和Ⅳ组饲喂不含抗菌药的基础日粮，Ⅱ和Ⅴ组基础日粮中添加100mg／kg喹乙醇，Ⅲ和Ⅵ组基础日粮中添加100mg／kg喹赛多。Ⅳ、Ⅴ和Ⅵ组仔猪灌服10^10CFU大肠杆菌（O139；K86），Ⅰ、Ⅱ和Ⅲ组仅灌服肉汤。喹赛多饲喂猪直肠粪便中大肠杆菌总数和接种血清型大肠杆菌数与喹乙醇饲喂猪均无显著差异（P〉0.05），喹赛多和喹乙醇饲喂猪直肠粪便中接种血清型大肠杆菌数均低于非药物饲喂猪（P〈0．05）。饲料中添加药物可降低空、回肠上皮内淋巴细胞和IgA分泌细胞数（P〈0．05）；喹赛多饲喂猪空肠IgA分泌细胞数低于喹乙醇饲喂猪（P〈0．05）。大肠杆菌接种降低仔猪平均日增重（P〈0．05），药物显著改善平均日增重（P〈0．05）；喹赛多饲喂猪平均日增重在整个试验期高于喹乙醇饲喂猪（P〈0．05）；这些结果显示喹赛多减少肠道大肠杆菌数量，抑制因肠道接种刺激所引起的免疫激活，特别是肠道免疫激活，以促进仔猪生长。 相似文献
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喹赛多对鱼类常见致病菌的试管内抑菌作用 总被引：6，自引：0，他引：6
用试管法测定了喹赛多对4种鱼类常见致病菌的8个菌株的抑菌活性。结果表明，喹赛多对几种供试菌均显示出较强的抑菌活性，对柱状嗜纤维菌的最小抑菌浓度（MIC）为0．39μg/ml，嗜水气单胞菌为0．78μg/ml，鳗弧菌为0．78－1．56μm/ml,迟缓爱德华氏菌为0．39－0．78μmg/ml。喹赛多的抑菌活性较盐酸土霉素、磺胺二甲嘧啶和盐酸金霉素弱，而较喹乙醇强。因此，以喹赛多替代喹乙醇作为饲料添加药物对于预防鱼类细菌性疾病是适宜的。 相似文献
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Adeel Sattar Mian Abdul Hafeez Qin Wu Adnan Hassan Tahir Muhammad Abu Bakr Shabbir Dongmei Chen Lingli Huang Shuyu Xie Zonghui Yuan 《Journal of veterinary pharmacology and therapeutics》2020,43(2):97-107
Cyadox (CYX) is a synthetic antibacterial agent of quinoxaline with much lower toxic effects. A safety criterion of CYX for clinical use was established by studying the pharmacokinetics and metabolism of CYX after oral (PO), intramuscular (IM), and intravenous (IV) administration. CYX was administered in six domesticated cats (three males and three females) by PO (40 mg/kg.b.w.), IM (10 mg/kg.b.w.), and IV (10 mg/kg.b.w.) routes in a crossover pattern. Highly sensitive liquid chromatography with ultraviolet detection (HPLC-UV) method was developed for detection of CYX and its metabolites present in plasma, urine, and feces. The bioavailability of CYX after PO and IM routes was 4.37% and 84.4%. The area under curves (AUC), mean resident time (MRT), and clearance (CL) of CYX and its metabolites revealed that CYX quickly metabolized into its metabolites. The total recovery of CYX and its main metabolites was >60% after each route. PO delivery suggesting first pass effect in cats that might make this route suitable for intestinal infection and IM injection could be better choice for systemic infections. Less ability of glucuronidation did not show any impact on CYX metabolism. The findings of present study provide detailed information for evaluation of CYX. 相似文献
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喹赛多对家禽常见病原菌的体外抗菌活性研究 总被引：5，自引：0，他引：5
采用试管二倍稀释法测定喹赛多对家禽6种13株常见病原菌的体外抑菌活性．结果表明;喹赛多对家禽革兰氏阳性菌和革兰氏阴性菌均有较强的抑制作用,对鸡大肠杆菌、金黄色葡萄球菌和沙门氏菌抑菌活性最明显,其最小抑菌浓度(MIC)分别为0．62、1．25和0．62μg/mL．该药对大肠杆菌还表现出杀菌活性,最小杀菌浓度(MBC)≥80μg/mL．喹赛多抗菌活性与喹乙醇相近,强于磺胺二甲嘧啶,比盐酸金霉素略差．这些结果表明,喹赛多是一种活性较强的抑菌剂,可推荐用作家禽常见病原菌感染的预防药物． 相似文献