| 硬骨鱼免疫相关microRNA研究进展 |
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| 引用本文： | 汪小冬,金生振,赵鑫,熊舒婷,肖调义.硬骨鱼免疫相关microRNA研究进展[J].水产学报,2021,45(8):1430-1437. |
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| 作者姓名： | 汪小冬 金生振 赵鑫 熊舒婷 肖调义 |
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| 作者单位： | 1.湖南省特色水产资源利用工程中心,1.湖南省特色水产资源利用工程中心,1.湖南省特色水产资源利用工程中心,1.湖南省特色水产资源利用工程中心,1.湖南省特色水产资源利用工程中心 |
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| 基金项目： | 国家自然科学基金（31972787） 湖南农业大学双一流建设项目(SYL201802020) |
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| 摘 要： | MicroRNA (miRNA)是一类长度为18～25 nt的非编码RNA,在硬骨鱼免疫应答中起重要作用。近年来,借助高通量测序与荧光定量PCR (RT-PCR)技术,筛选到大量免疫相关的差异表达miRNA (DE miRNA)。通过比较多种硬骨鱼在不同病毒/细菌感染条件的miRNA表达谱,筛选出相同DE miRNA,并认为筛选出的DE miRNA是潜在参与调节宿主免疫应答的进化上保守的候选DE miRNA。据此,我们在病毒感染表达谱中筛选到10个进化保守的DE miRNA,细菌感染表达谱中筛选到8个保守的DE miRNA。此外,miRNA的功能研究也取得较大进展,宿主miRNA不仅可直接抑制病毒的复制,同时参与调控干扰素反应、炎症、细胞凋亡等过程。本文简述了硬骨鱼免疫相关miRNA的研究进展,以期为硬骨鱼疾病预防与治疗提供新思路。
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| 关 键 词： | 硬骨鱼 免疫应答 差异表达miRNA 保守miRNA |
| 收稿时间： | 2020/3/21 0:00:00 |
| 修稿时间： | 2020/4/26 0:00:00 |
Advances of immune-related microRNA research in teleost fish |
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| WANG Xiaodong,JIN Shengzhen,ZHAO Xin,XIONG Shuting,XIAO Tiaoyi.Advances of immune-related microRNA research in teleost fish[J].Journal of Fisheries of China,2021,45(8):1430-1437. |
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| Authors: | WANG Xiaodong JIN Shengzhen ZHAO Xin XIONG Shuting XIAO Tiaoyi |
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| Institution: | Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization,Hunan Agricultural University,Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization,Hunan Agricultural University,Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization,Hunan Agricultural University,Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization,Hunan Agricultural University,Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization,Hunan Agricultural University |
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| Abstract: | MicroRNAs, which are small non-coding RNAs with 18-25 nt, play important roles in? immune response of teleost fish. Recently, more and more differentially expressed miRNAs (DE miRNAs) associated with immune response have been identified through high-throughput sequencing and RT-RCR technology. It is assumed that if the same miRNAs are detected as DE miRNAs in several species of teleost fish challenged with different viruses / bacteria, they are likely to be evolutionarily conserved miRNAs involved in the regulation of immune gene networks in the hosts. Based on the above assumption, ten miRNAs have been discovered as responding to viral challenge, and eight miRNAs were described in response to bacterial challenge. In addition, the functional study of miRNA has also attracted attention with rather marked progress. It has been identified that miRNAs involved in many immune response processes, such as in preventing the virus replication, in regulating interferon response, inflammation and cell apoptosis, etc. This paper reviews the recent research progress of immune-related miRNAs, and it will provide new ideas for disease prevention and treatment in teleost fish. |
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| Keywords: | teleost fish immune response DE miRNA conserved miRNAs |
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