Sex difference feeding behaviour of NOD SCID mice in a pharmacological model of type 1 diabetes |
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| Authors: | Daria A Tur Nikita V Khotskin Andrey E Akulov |
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| Institution: | The Federal Research Center Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia |
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| Abstract: | This study aimed to assess the sex differences in the feeding behaviour of non-obese diabetic severe combined immunodeficient (NOD SCID) mice in a pharmacological model of type 1 diabetes mellitus (T1Dm). In our study, we chose NOD SCID mice of both sexes and assessed their feeding behaviour, body weight, body fat and water content under identical experimental conditions and diets. After 1 month of diabetes mellitus in mice in the experimental group, males and females did not show any increase in body weight, and they weighed significantly less than the control group. However, compared with the control group, in females with a background of T1Dm, there was a significant decrease in body fat. The amount of water consumed in the experimental groups was higher than that in the control groups. The amount of food consumed by males increased when they increased their water consumption, whereas food consumption in females decreased significantly with an increase in water consumption. Thus, we discovered sex differences in the feeding behaviour, body weight and body fat and water content in the pharmacological model of T1Dm after 1 month in NOD SCID mice. |
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| Keywords: | body fat body weight feeding behaviour mice type 1 diabetes |
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