| 4、5、7月龄雌性大鼠骨计量学参数的变化及意义 |
| |
| 引用本文： | 康毅,金勋杰,刘双意,林柏云,李青南,吴铁.4、5、7月龄雌性大鼠骨计量学参数的变化及意义[J].湛江医学院学报,2003,21(2):102-104. |
| |
| 作者姓名： | 康毅 金勋杰 刘双意 林柏云 李青南 吴铁 |
| |
| 作者单位： | [1]广东医学院附属医院骨科，广东湛江524001 [2]广东医学院骨生物学研究室，广东湛江524001 [3]广东医学院药理学教研室，广东湛江524001 |
| |
| 摘 要： | 目的：观察4、5和7各月龄SD♀大鼠的骨量、骨形成和骨吸收的变化。方法：21只3．5月龄♀大鼠按随机排列表随机分为3组：4月龄组6只、5月龄组8只、7月龄组7只。大鼠饲养至相应月龄时处死后做骨计量学分析。结果：各组间骨小梁面积百分率(％Tb．Ar)差异无显著性；5月龄组与4月龄组比较，反映骨形成的参数矿化沉积率(MAR)、骨形成率(BFR／BS、BFR／BV、BFR／TV)都降低，7月龄组与4月龄组比较，所有反映骨形成和骨吸收的参数都降低。结论：在4—7月龄期间，SD♀大鼠的骨形成和骨吸收活性下降，但仍保持平衡状态，骨量无显著性变化。
|
| 关 键 词： | 雌性大鼠 骨计量学参数 变化 骨形成 骨吸收 |
| 文章编号： | 1005-4057(2003)-02-0102-03 |
| 修稿时间： | 2001年9月30日 |
Bone histomorphometric assay in female rats aged 4,5,and 7 months |
| |
| KANG Yi,JIN Xun jie,LIU Shuang yi,et al.Bone histomorphometric assay in female rats aged 4,5,and 7 months[J].Journal of Guangdong Medical College,2003,21(2):102-104. |
| |
| Authors: | KANG Yi JIN Xun jie LIU Shuang yi |
| |
| Abstract: | Objective:To provide bone histomorphometric parameters in female rats.Methods:Twenty one female SD rats at the age of 3.5 months were randomly divided into 3 groups:4 month group( n =6),5 month group( n =8),7 month group( n =7).The rats in 3 groups were not sacrificed until they were fed at their respective months,and their proximal tibiae were assayed by histomorphometry.Results:There was no statistical significance in area of bone trabecula between 3 groups.Compared with 4 month group,the parameters of bone formation such as MAR,BFR/BS,BFR/BV and BFR/TV in 5 moth group decreased obviously,and all parameters that reflected bone formation and resorption in 7 month group lowered substantially.Conclusion:Though the bone formation and resorption lessened in female SD rats aged from 4 to 7 months,bone volume remains unchangeable. |
| |
| Keywords: | rat female bone histomorphometry |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
