|
|||||
|
|
A comparison of subarachnoid buprenorphine or xylazine as an adjunct to lidocaine for analgesia in goats |
|
| Authors: | Francesco Staffieri † DMV PhD Bernd Driessen† ‡ DVM Dr med vet Diplomate ACVA & ECVPT Luca Lacitignola§ DMV PhD & Antonio Crovace DMV |
| Institution: | Dipartimento dell'Emergenza e dei Trapianti di Organi (D.E.T.O.), Sezione di Chirurgia Veterinaria, Facoltàdi Medicina Veterinaria, Universitàdegli Studi di Bari, Valenzano (Bari), Italy; Department of Clinical Studies, New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, Kennett Square, PA, USA; Department of Anesthesiology, University of California-Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA; Dipartimento dell' Scienze Cliniche Veterinarie, Sezione di Chirurgia Veterinaria, Facoltàdi Medicina Veterinaria, Universitàdegli Studi di Teramo, Teramo, Italy |
| Abstract: | ObjectiveTo test the hypothesis that subarachnoid administration of buprenorphine and lidocaine provides more intense and longer lasting perioperative analgesia with less side effects than xylazine and lidocaine in goats.Study designRandomized, blinded, controlled study.Study animals Ten healthy female goats randomly assigned to two groups of five animals each.MethodsAfter sedation with acepromazine (0.1 mg kg?1) intravenously (IV), lidocaine 2% (0.1 mL kg?1) combined with either xylazine (0.05 mg kg?1; Group X) or buprenorphine (0.005 mg kg?1; Group B) were injected intrathecally at the lumbo-sacral junction prior to stifle surgery. Electrocardiogram, heart rate, direct systolic, mean, and diastolic arterial blood pressures, rectal temperature and arterial blood gases were recorded as were post-operative sedation and pain scores using a visual analogue and numeric rating scale, respectively. Data were analyzed with one-way anova for repeated measures, one-way anova, Friedman's and Kruskal–Wallis tests as necessary (p< 0.05).ResultsSurgery was successfully performed under both analgesia protocols. Total pain and sedation scores were significantly lower in the B as compared with X group from 3–24 hours and 30–120 minutes, respectively after subarachnoid drug administration (SDA). Heart rate and arterial blood pressures decreased post SDA and were consistently lower in X versus B (p< 0.05). In B arterial blood gas parameters did not change post SDA, but in group X PaCO2 increased slightly within 15 minutes of SDA and remained elevated for at least 3 hours (p< 0.05).ConclusionIn these goats intrathecal administration of buprenorphine and lidocaine produced more profound and longer lasting analgesia with less sedation and hemodynamic and respiratory impairment than xylazine with lidocaine.Clinical relevanceIn these goats undergoing hind limb surgery, subarachnoid buprenorphine/lidocaine offered more intense and longer lasting analgesia than a xylazine/lidocaine combination, with less sedation and impairment of cardiopulmonary function. |
| Keywords: | buprenorphine goat lidocaine pain score subarachnoid (intrathecal) anaesthesia xylazine |
| 本文献已被 ScienceDirect 等数据库收录！ | |