| 马立克氏病病毒肿瘤Meq基因缺失株的保护性免疫作用 |
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| 引用本文： | 崔治中.马立克氏病病毒肿瘤Meq基因缺失株的保护性免疫作用[J].中国兽药杂志,2010,44(10):2-5. |
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| 作者姓名： | 崔治中 |
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| 作者单位： | 山东农业大学动物医学院 |
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| 基金项目： | 国家自然科学基金项目（面上项目） |
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| 摘 要： | 马立克氏病病毒（MDV）的致病性一直在不断增强中,甚至已出现了能抵抗CV1988/Rispens疫苗的特超强株。本实验室用BAC克隆技术构建了MDV中国野毒株的Meq基因缺失株,显示出在抗马立克氏病方面具有与美国Meq基因缺失株同样有效的保护性免疫效果,而且其自身没有明显的免疫抑制作用。对美国和中国的两个MDV的Meg基因缺失株的优缺点做了比较。
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| 关 键 词： | 马立克氏病病毒 Meq基因缺失株 保护性免疫 |
| 收稿时间： | 2010/8/27 0:00:00 |
| 修稿时间： | 2010/8/27 0:00:00 |
Comparison of Marek＇s Disease Virus Meq-deletion Mutants for Their Protective Immunity |
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| cuizhizhong.Comparison of Marek＇s Disease Virus Meq-deletion Mutants for Their Protective Immunity[J].Chinese Journal of Veterinary Drug,2010,44(10):2-5. |
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| Authors: | cuizhizhong |
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| Institution: | College of Veterinary Medicine, Shandong Agricultural University |
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| Abstract: | The pathogenicity of Marek＇s disease viruses（MDV） is being continuously increased,even some very virulent plus MDV strains resistant to CVI988/Rispens emerged.A Meq-deletion mutant from Chinese field strain GX0101 with BAC clone technique was constructed in our lab,it also demonstrated better protective immunity than CVI988.In this paper,both Meq-deletion mutants from America and China were compared for their protective immunity and other biological characteristics. |
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| Keywords: | Marek＇s disease viruses Meq-deletion mutants protective immunity |
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